{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:32:42Z","timestamp":1790109162241,"version":"4.0.1"},"reference-count":45,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u2018Victor Babes\u2019 University of Medicine and Pharmacy Timisoara"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: Hydrocephalus is a complex neurological disorder marked by abnormal cerebrospinal fluid dynamics and ventricular enlargement. Despite breakthroughs in neuroimaging, diagnosis and longitudinal the application of imaging markers for the diagnosis and longitudinal monitoring of hydrocephalus remains challenging in routine clinical practice. The present study examines the behavior and cross-modality agreement of commonly used linear ventricular measurements under routine imaging conditions, at a single Romanian tertiary-care center characterized by heterogeneous acquisition protocols and limited availability of advanced volumetric techniques. Methods: We conducted a single-center retrospective observational study of 68 adults with hydrocephalus. Linear ventricular metrics, including Evans index and third-ventricle width, were measured on all available CT and MRI scans. CT\u2013MRI agreement was assessed using paired examinations within a 90-day window. Longitudinal changes were analyzed using first\u2013last and pre\u2013post VP shunt comparisons. Associations between baseline imaging features and VP shunt placement were evaluated using rule-based and odds ratio analyses. Results: CT and MRI measurements demonstrated strong agreement for both Evans index (r = 0.93) and third-ventricle width (r = 0.90), with minimal systematic bias. Longitudinal analyses demonstrated small-magnitude changes in ventricular size following intervention, with substantial inter-individual variability. VP utilization increased across Evans index strata, reaching 100% in patients with values \u22650.50. Transependymal cerebrospinal fluid exudation showed the strongest association with subsequent VP shunting. Imaging-based rules exhibited expected trade-offs between sensitivity and specificity. Conclusions: Standard linear ventricular parameters exhibited adequate cross-modality agreement and clinically important longitudinal behavior in this cohort. While insufficient as standalone predictors, these readily available imaging markers remain important tools when combined with a comprehensive clinical assessment.<\/jats:p>","DOI":"10.3390\/diagnostics16030491","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T15:24:19Z","timestamp":1770305059000},"page":"491","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ventricular Anatomy Across CT and MRI in Hydrocephalus: A Retrospective Study"],"prefix":"10.3390","volume":"16","author":[{"given":"Andrada-Iasmina","family":"Ro\u015fu","sequence":"first","affiliation":[{"name":"Doctoral School, University of Medicine and Pharmacy \u201cVictor Babes\u201d, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"},{"name":"Department of Anesthesia and Intensive Care, University of Medicine and Pharmacy \u201cVictor Babes\u201d, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5326-5438","authenticated-orcid":false,"given":"Laura Andreea","family":"Ghenciu","sequence":"additional","affiliation":[{"name":"Department of Functional Sciences, Discipline of Pathophysiology, University of Medicine and Pharmacy \u201cVictor Babes\u201d, 300041 Timisoara, Romania"},{"name":"Center for Translational Research and Systems Medicine, University of Medicine and Pharmacy \u201cVictor Babes\u201d, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan Cristian","family":"Ro\u015fu","sequence":"additional","affiliation":[{"name":"1st Surgery Clinic, University of Medicine and Pharmacy \u201cVictor Babes\u201d, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5863-6613","authenticated-orcid":false,"given":"Emil-Radu","family":"Iacob","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, University of Medicine and Pharmacy \u201cVictor Babes\u201d, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4620-3340","authenticated-orcid":false,"given":"Emil Robert","family":"Stoicescu","sequence":"additional","affiliation":[{"name":"Department of Radiology and Medical Imaging, University of Medicine and Pharmacy \u201cVictor Babes\u201d, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"},{"name":"Research Center for Pharmaco-Toxicological Evaluations, University of Medicine and Pharmacy \u201cVictor Babes\u201d, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"},{"name":"Field of Applied Engineering Sciences, Specialization Statistical Methods and Techniques in Health and Clinical Research, Faculty of Mechanics, Politehnica University Timisoara, Mihai Viteazul Boulevard No. 1, 300222 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2894-712X","authenticated-orcid":false,"given":"Roxana","family":"Stoicescu","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Embriology, University of Medicine and Pharmacy \u201cVictor Babes\u201d, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9118-9133","authenticated-orcid":false,"given":"Alexandra Ioana","family":"D\u0103nil\u0103","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Embriology, University of Medicine and Pharmacy \u201cVictor Babes\u201d, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorin Lucian","family":"Bolintineanu","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Embriology, University of Medicine and Pharmacy \u201cVictor Babes\u201d, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"117702","DOI":"10.1016\/j.biopha.2024.117702","article-title":"Hydrocephalus: An Update on Latest Progress in Pathophysiological and Therapeutic Research","volume":"181","author":"Anwar","year":"2024","journal-title":"Biomed. 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