{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:36:23Z","timestamp":1790706983734,"version":"4.1.0"},"reference-count":122,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Interventional endoscopic ultrasound (EUS) has become a cornerstone in the management of malignant pancreatobiliary diseases, offering minimally invasive alternatives to traditional surgical approaches. More recently, accumulating evidence supports its expanding role in the treatment of benign pancreatobiliary conditions, including acute cholecystitis and pancreatitis, benign gastric outlet obstruction, and scenarios involving altered gastrointestinal anatomy. This narrative review provides an overview of key EUS-guided drainage techniques utilizing lumen-apposing metal stents (LAMSs) in benign settings. It focuses on procedures such as EUS-guided gallbladder drainage, drainage of abdominal collections, EUS-directed transgastric ERCP (EDGE), and EUS-gastroenterostomy. These interventions have demonstrated high technical and clinical success rates, favorable safety profiles, and expanding indications, particularly among patients who are poor surgical candidates. This review highlights evolving techniques, clinical outcomes, and the impact of device innovations on procedural efficacy and safety.<\/jats:p>","DOI":"10.3390\/diagnostics16040522","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T16:13:32Z","timestamp":1770653612000},"page":"522","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Endoscopic Ultrasound-Guided Lumen-Apposing Metal Stent Drainage in Benign Pancreatobiliary and Gastrointestinal Disease: Evolving Techniques and Clinical Outcomes"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5453-3310","authenticated-orcid":false,"given":"Filippo","family":"Antonini","sequence":"first","affiliation":[{"name":"Gastroenterology and Interventional Endoscopy Unit, C. e G. Mazzoni Hospital, 63100 Ascoli Piceno, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Valvano","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Galliera Hospital, 16128 Genoa, Italy"},{"name":"Gastroenterology Unit, Division of Gastroenterology, Hepatology, and Nutrition, Department of Life, Health and Environmental Sciences, University of L\u2019Aquila, 67100 L\u2019Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Troncone","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine, University of Rome \u201cTor Vergata\u201d, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8823-0665","authenticated-orcid":false,"given":"Domenico","family":"Galasso","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Internal Medicine Service, Hopital Riviera-Chablais, 1847 Rennaz, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amedeo","family":"Montale","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Galliera Hospital, 16128 Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2023-5157","authenticated-orcid":false,"given":"Mario","family":"Capasso","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Unit, ASST Ospedale Maggiore, 26013 Crema, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Marasco","sequence":"additional","affiliation":[{"name":"Gastroenterology and Digestive Endoscopy Unit, Santa Rosa Hospital, 01100 Viterbo, Italy"},{"name":"Department of Medical and Surgical Sciences and Transitional Medicine, Sapienza University, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0611-7448","authenticated-orcid":false,"given":"Benedetto","family":"Mangiavillano","sequence":"additional","affiliation":[{"name":"Gastrointestinal Endoscopy Unit, Humanitas Mater Domini, 21053 Castellanza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6327-563X","authenticated-orcid":false,"given":"Giovanna","family":"Del Vecchio Blanco","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine, University of Rome \u201cTor Vergata\u201d, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Dalla Libera","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Unit, ASL 2 Savonese, 17100 Savona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Scarcelli","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, \u201cSan Salvatore\u201d Hospital, 61121 Pesaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2107-2156","authenticated-orcid":false,"given":"Antonio","family":"Facciorusso","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Faculty of Medicine and Surgery, University of Salento, 73100 Lecce, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8618-2447","authenticated-orcid":false,"given":"Lorenzo","family":"Fuccio","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Department of Medical and Surgical Sciences, IRCCS Azienda Ospedaliero-Universitaria di Bologna (IRCCS University Hospital of Bologna), University of Bologna, 40125 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6591-612X","authenticated-orcid":false,"given":"Massimiliano","family":"Mutignani","sequence":"additional","affiliation":[{"name":"Endoscopy Unit, ASST Grande Ospedale Metropolitano Niguarda, 20162 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Perez-Miranda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospital Rio Hortega, 47012 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1055\/a-1738-6780","article-title":"Therapeutic Endoscopic Ultrasound: European Society of Gastrointestinal Endoscopy (ESGE) Technical Review","volume":"54","author":"Bronswijk","year":"2022","journal-title":"Endoscopy"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/den.14173","article-title":"Advances in Therapeutic Interventional Endoscopic Ultrasound","volume":"34","author":"Irisawa","year":"2022","journal-title":"Dig. 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