{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T07:59:43Z","timestamp":1771919983704,"version":"3.50.1"},"reference-count":97,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:00:00Z","timestamp":1771632000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union\u2014Next Generation EU","award":["LX22NPO5103"],"award-info":[{"award-number":["LX22NPO5103"]}]},{"DOI":"10.13039\/501100003243","name":"Ministry of Health of the Czech Republic","doi-asserted-by":"crossref","award":["NW24-09-00505"],"award-info":[{"award-number":["NW24-09-00505"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Third Faculty of medicine, Charles University, Prague","award":["207035"],"award-info":[{"award-number":["207035"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: Human papillomavirus (HPV) is the most common sexually transmitted viral infection worldwide. Moreover, the prevalence of HPV infection is twice as high in pregnant women as in non-pregnant individuals. The aim of this review was to examine adverse pregnancy outcomes associated with cervicovaginal or placental HPV infection confirmed by a sensitive molecular method. Methods: We conducted searches on major medical databases including PubMed, EMBASE, Global Health, and the Cochrane Library to identify all studies examining HPV infection during pregnancy. Additionally, other online sources were consulted for relevant studies. Thirty-four records out of the initial 1868 identified were included in this review for thematic synthesis. The PRISMA-ScR guidelines were followed. Results: This scoping review included a total of 28 original observational studies, 1 systematic review, and 5 meta-analyses. Active HPV infection appears to significantly increase the risk of preterm premature rupture of membranes and preterm birth, as indicated by findings from published meta-analyses and systematic reviews. Determining the association of HPV infection with certain adverse pregnancy outcomes is challenging due to their frequency (such as miscarriage) or rarity (such as intrauterine fetal death). For conditions like preeclampsia and intrauterine fetal growth restriction, the limited number of heterogeneous studies precludes definitive conclusions. Moreover, the causes of these outcomes are typically multifactorial. The presence of HPV in trophoblasts and placental tissue is considered crucial for potential adverse pregnancy outcomes. There appears to be a strong correlation between cervicovaginal or urinary HPV infections and placental HPV infections in pregnant women. Conclusions: Persistent HPV infection seems to elevate the risk of preterm premature rupture of membranes and preterm birth. However, the currently available observational evidence does not allow for definitive conclusions regarding causality, and the reported findings should be interpreted as associations rather than proof of a causal relationship. The changes in frequency of certain perinatal complications in populations of women with high HPV vaccination rates may shed more light on this connection.<\/jats:p>","DOI":"10.3390\/diagnostics16040629","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T11:39:10Z","timestamp":1771846750000},"page":"629","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Effect of Human Papillomavirus Infection on Pregnancy Outcomes: A Scoping Review"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2622-2181","authenticated-orcid":false,"given":"Borek","family":"Sehnal","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, University Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University, 100 34 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Zapletal","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, University Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University, 100 34 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7606-5164","authenticated-orcid":false,"given":"Martin","family":"Hruda","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, University Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University, 100 34 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vit","family":"Drochytek","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, University Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University, 100 34 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katerina","family":"Maxova","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, University Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University, 100 34 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Halaska","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, University Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University, 100 34 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Rob","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, University Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University, 100 34 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Tachezy","sequence":"additional","affiliation":[{"name":"Department of Genetics and Microbiology, Faculty of Science, Biotechnology and Biomedicine Centre of the Academy of Sciences and Charles University, Charles University, 128 00 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"F12","DOI":"10.1016\/j.vaccine.2012.07.055","article-title":"Global burden of human papillomavirus and related diseases","volume":"30","author":"Forman","year":"2012","journal-title":"Vaccine"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S1470-2045(09)70096-8","article-title":"A review of human carcinogens\u2014Part B: Biological agents","volume":"10","author":"Bouvard","year":"2009","journal-title":"Lancet Oncol."},{"key":"ref_3","first-page":"72","article-title":"Pandemic of hepatitis C virus infection","volume":"65","year":"2016","journal-title":"Epidemiol. Mikrobiol. Imunol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e180","DOI":"10.1016\/S2214-109X(19)30488-7","article-title":"Global burden of cancer attributable to infections in 2018: A worldwide incidence analysis","volume":"8","author":"Georges","year":"2020","journal-title":"Lancet Glob. Health"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e2374","DOI":"10.1002\/rmv.2374","article-title":"Worldwide prevalence of human papillomavirus among pregnant women: A systematic review and meta-analysis","volume":"33","author":"Ardekani","year":"2023","journal-title":"Rev. Med. Virol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.11124\/JBIES-20-00167","article-title":"Updated methodological guidance for the conduct of scoping reviews","volume":"18","author":"Peters","year":"2020","journal-title":"JBI Evid. Synth."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1748-5908-5-69","article-title":"Scoping studies: Advancing the methodology","volume":"5","author":"Levac","year":"2010","journal-title":"Implement. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s40900-022-00361-x","article-title":"Protocol for a scoping review to map patient engagement in scoping reviews","volume":"8","author":"Oravec","year":"2022","journal-title":"Res. Involv. Engagem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"467","DOI":"10.7326\/M18-0850","article-title":"PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation","volume":"169","author":"Tricco","year":"2018","journal-title":"Ann. Intern Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"48","DOI":"10.12688\/wellcomeopenres.15140.1","article-title":"HPV infection and pre-term birth: A data-linkage study using Scottish Health Data","volume":"4","author":"Aldhous","year":"2019","journal-title":"Wellcome Open Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1111\/aogs.13190","article-title":"Human papillomavirus infects placental trophoblast and Hofbauer cells, but appears not to play a causal role in miscarriage and preterm labor","volume":"96","author":"Leonhard","year":"2017","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"543","DOI":"10.3855\/jidc.1675","article-title":"Correlates of HPV: A cross-sectional study in women with normal cytology in north-central Morocco","volume":"6","author":"Bennani","year":"2012","journal-title":"J. Infect. Dev. Ctries."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"72","DOI":"10.5603\/GP.2019.0012","article-title":"Influence of human Papilloma Virus (hPV) infection on early pregnancy","volume":"90","author":"Bober","year":"2019","journal-title":"Ginekol. Pol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Bruno, M.T., Caruso, S., Scalia, G., Costanzo, M., Di Pasqua, S., Boemi, S., Panella, M.M., and Palumbo, M. (2023). Papillomavirus Infection as Potential Cause of Miscarriage in the Early Gestational Age: A Prospective Study. Diagnostics, 13.","DOI":"10.3390\/diagnostics13091659"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1089\/jwh.2018.7043","article-title":"Maternal Human Papillomavirus and Preterm Premature Rupture of Membranes: A Retrospective Cohort Study","volume":"28","author":"Caballero","year":"2019","journal-title":"J. Womens Health"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Cho, G., Min, K.-J., Hong, H.-R., Kim, S., Hong, J.-H., Lee, J.-K., Oh, M.-J., and Kim, H. (2013). High-risk human papillomavirus infection is associated with premature rupture of membranes. BMC Pregnancy Childbirth, 13.","DOI":"10.1186\/1471-2393-13-173"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.ejogrb.2013.07.002","article-title":"Human papillomavirus infection and spontaneous abortion: A case-control study performed in Mexico","volume":"170","year":"2013","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1093\/humrep\/dem404","article-title":"Placental infection with human papillomavirus is associated with spontaneous preterm delivery","volume":"23","author":"Gomez","year":"2008","journal-title":"Hum. Reprod."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Hornychova, H., Kacerovsky, M., Musilova, I., Pliskova, L., Zemlickova, H., Matejkova, A., Vosmikova, H., Rozkosova, K., Cermakova, P., and Bolehovska, R. (2018). Cervical human papillomavirus infection in women with preterm prelabor rupture of membranes. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0207896"},{"key":"ref_21","first-page":"100068","article-title":"Prevalence of human papillomavirus infection in oocyte donors and women treated for infertility: An observational laboratory-based study","volume":"4","author":"Jaworek","year":"2019","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol. X"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"143","DOI":"10.2174\/1573404814666180517085022","article-title":"HPV Prevalence and Its association with Perinatal Outcomes among Singleton Mothers: Analysis of Pregnancy Risk Assessment and Monitoring System (PRAMS) Data, 2004\u20132011","volume":"15","author":"Kaur","year":"2019","journal-title":"Curr. Women\u2019s Health Rev."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"981","DOI":"10.24976\/Discov.Med.202436184.91","article-title":"Genotype Distribution and Prevalence of High-Risk Human Papillomavirus among Pregnant Women and Maternal-Fetal Pregnancy Outcomes in a Tertiary Hospital in Beijing, China","volume":"36","author":"Liu","year":"2024","journal-title":"Discov. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1080\/09674845.2010.11978230","article-title":"Maternal human papillomavirus (HPV) infection and its possible relationship with neonatal prematurity","volume":"67","author":"Mammas","year":"2010","journal-title":"Br. J. Biomed. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"138.e1","DOI":"10.1016\/j.ajog.2013.09.040","article-title":"High risk human papillomavirus at entry to prenatal care and risk of preeclampsia","volume":"210","author":"McDonnold","year":"2014","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1080\/14767058.2017.1297403","article-title":"High-risk and low-risk human papilloma virus in association to spontaneous preterm labor: A case-control study in a tertiary center, Egypt","volume":"31","author":"Mosbah","year":"2018","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e2125308","DOI":"10.1001\/jamanetworkopen.2021.25308","article-title":"Association Between Human Papillomavirus Infection Among Pregnant Women and Preterm Birth","volume":"4","author":"Niyibizi","year":"2021","journal-title":"JAMA Netw. Open"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"4376902","DOI":"10.1155\/2019\/4376902","article-title":"Human Papillomavirus (HPV) Infection in Early Pregnancy: Prevalence and Implications","volume":"2019","author":"Pandey","year":"2019","journal-title":"Infect. Dis. Obstet. Gynecol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1111\/j.1600-0412.2011.01189.x","article-title":"Prevalence of human papillomavirus in spontaneously aborted products of conception","volume":"90","year":"2011","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1038\/modpathol.2015.88","article-title":"A clinicopathological study of episomal papillomavirus infection of the human placenta and pregnancy complications","volume":"28","author":"Slatter","year":"2015","journal-title":"Mod. Pathol."},{"key":"ref_31","first-page":"343","article-title":"Recurrent miscarriage and cervical human papillomavirus infection","volume":"70","author":"Ticconi","year":"2013","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.placenta.2024.05.126","article-title":"Placental human papillomavirus infections and adverse pregnancy outcomes","volume":"152","author":"Staff","year":"2024","journal-title":"Placenta"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/aogs.14509","article-title":"Maternal human papillomavirus infection during pregnancy and preterm delivery: A mother-child cohort study in Norway and Sweden","volume":"102","author":"Wiik","year":"2023","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Wiik, J., Nilsson, S., K\u00e4rrberg, C., Strander, B., Jacobsson, B., and Sengpiel, V. (2021). Associations of treated and untreated human papillomavirus infection with preterm delivery and neonatal mortality: A Swedish population-based study. PLoS Med., 18.","DOI":"10.1371\/journal.pmed.1003641"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1309\/AJCP93JMIUEKRPIW","article-title":"Association of cervical cytology and HPV DNA status during pregnancy with placental abnormalities and preterm birth","volume":"136","author":"Zuo","year":"2011","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"10138","DOI":"10.1038\/s41598-025-94563-4","article-title":"The distribution and the relationship of HPV subtypes infection with pregnancy outcomes","volume":"15","author":"Lin","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"V\u00e6rnesbranden, M.R., Staff, A.C., Wiik, J., Sj\u00f8borg, K., Rueegg, C.S., Sugulle, M., Carlsen, K.C.L., Granum, B., Haugen, G., and Hedlin, G. (2024). Human papillomavirus infections during pregnancy and adverse pregnancy outcomes: A Scandinavian prospective mother-child cohort study. BMC Pregnancy Childbirth, 24.","DOI":"10.1186\/s12884-024-06958-2"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"He, N., Song, X., Song, Q., and Ding, H. (2025). Prevalence of HPV genotypes and their association with reproductive tract inflammation and pregnancy outcomes among reproductive-age women in Ningbo, China: A retrospective cohort study (2016\u20132020). BMC Infect. Dis., 25.","DOI":"10.1186\/s12879-025-10522-4"},{"key":"ref_39","first-page":"3086036","article-title":"Human Papillomavirus Infection as a Possible Cause of Spontaneous Abortion and Spontaneous Preterm Delivery","volume":"2016","author":"Baandrup","year":"2016","journal-title":"Infect. Dis. Obstet. Gynecol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.jcv.2014.09.002","article-title":"Can HPV vaccine have other health benefits more than cancer prevention? A systematic review of association between cervical HPV infection and preterm birth","volume":"61","author":"Huang","year":"2014","journal-title":"J. Clin. Virol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1093\/infdis\/jiaa054","article-title":"Association Between Maternal Human Papillomavirus Infection and Adverse Pregnancy Outcomes: Systematic Review and Meta-Analysis","volume":"221","author":"Niyibizi","year":"2020","journal-title":"J. Infect. Dis."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"10735","DOI":"10.21037\/apm-21-2497","article-title":"Systematic review and meta-analysis on influence of human papillomavirus infection during pregnancy on premature rupture of membranes and premature delivery","volume":"10","author":"Wu","year":"2021","journal-title":"Ann. Palliat. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1159\/000482008","article-title":"The Risk of Human Papillomavirus Infection for Spontaneous Abortion, Spontaneous Preterm Birth, and Pregnancy Rate of Assisted Reproductive Technologies: A Systematic Review and Meta-Analysis","volume":"83","author":"Xiong","year":"2018","journal-title":"Gynecol. Obstet. Investig."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1111\/aogs.14913","article-title":"Association between human papillomavirus and preterm delivery: A systematic review and meta-analysis","volume":"103","author":"Hegyi","year":"2024","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.tjog.2020.07.005","article-title":"Human papilloma virus infection and miscarriage: Is there an association?","volume":"59","author":"Basonidis","year":"2020","journal-title":"Taiwan J. Obstet. Gynecol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.ejogrb.2021.07.053","article-title":"Human papillomavirus (HPV) in pregnancy\u2014An update","volume":"264","author":"Chilaka","year":"2021","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Condrat, C.E., Filip, L., Gherghe, M., Cretoiu, D., and Suciu, N. (2021). Maternal HPV Infection: Effects on Pregnancy Outcome. Viruses, 13.","DOI":"10.3390\/v13122455"},{"key":"ref_48","first-page":"329","article-title":"Correlation between human papillomavirus infection and reproduction","volume":"93","author":"Duan","year":"2022","journal-title":"Ginekol. Pol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Popescu, S.D., Boiangiu, A.G., Sima, R.-M., Bilteanu, L., Vladareanu, S., and Vladareanu, R. (2022). Maternal HPV Infection and the Estimated Risks for Adverse Pregnancy Outcomes\u2014A Systematic Review. Diagnostics, 12.","DOI":"10.3390\/diagnostics12061471"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Dedousi, D., Potiris, A., Zikopoulos, A., Karampitsakos, T., Topis, S., Skentou, C., Gerede, A., Christopoulos, P., Zachariou, A., and Domali, E. (2024). The Impact of Human Papillomavirus Infections on Recurrent Pregnancy Loss: A Review of the Literature. Diseases, 12.","DOI":"10.3390\/diseases12090214"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"6057","DOI":"10.1016\/j.vaccine.2016.03.044","article-title":"Stillbirth: Case definition and guidelines for data collection, analysis, and presentation of maternal immunization safety data","volume":"34","author":"Gonik","year":"2016","journal-title":"Vaccine"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Lawn, J.E., Gravett, M.G., Nunes, T.M., Rubens, C.E., and Stanton, C. (2010). GAPPS Review Group Global report on preterm birth and stillbirth (1 of 7): Definitions, description of the burden and opportunities to improve data. BMC Pregnancy Childbirth, 10.","DOI":"10.1186\/1471-2393-10-S1-S1"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ejogrb.2020.10.001","article-title":"A cross-sectional survey of pregnant women\u2019s knowledge of chromosomal aneuploidy and microdeletion and microduplication syndromes","volume":"256","author":"Yang","year":"2021","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1016\/S0140-6736(12)60820-4","article-title":"National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: A systematic analysis and implications","volume":"379","author":"Blencowe","year":"2012","journal-title":"Lancet"},{"key":"ref_55","unstructured":"(2024, May 05). Preterm Birth. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/preterm-birth."},{"key":"ref_56","first-page":"1","article-title":"Births: Final Data for 2019","volume":"70","author":"Martin","year":"2021","journal-title":"Natl. Vital. Stat. Rep."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.siny.2015.12.011","article-title":"The epidemiology, etiology, and costs of preterm birth","volume":"21","author":"Frey","year":"2016","journal-title":"Semin. Fetal Neonatal Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1093\/aje\/kwp131","article-title":"Placental vascular pathology findings and pathways to preterm delivery","volume":"170","author":"Kelly","year":"2009","journal-title":"Am. J. Epidemiol."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Samuel, T.M., Sakwinska, O., Makinen, K., Burdge, G.C., Godfrey, K.M., and Silva-Zolezzi, I. (2019). Preterm Birth: A Narrative Review of the Current Evidence on Nutritional and Bioactive Solutions for Risk Reduction. Nutrients, 11.","DOI":"10.3390\/nu11081811"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"American College of Obstetricians and Gynecologists (2020). Prelabor Rupture of Membranes: ACOG Practice Bulletin, Number 217. Obstet. Gynecol., 135, e80\u2013e97.","DOI":"10.1097\/AOG.0000000000003700"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"S137","DOI":"10.1097\/01.AOG.0000514690.21416.7c","article-title":"Maternal Human Papillomavirus Infection Increases the Risk of Premature Rupture of Membranes [19M]","volume":"129","author":"Dudley","year":"2017","journal-title":"Obstet. Gynecol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejogrb.2013.05.005","article-title":"Global and regional estimates of preeclampsia and eclampsia: A systematic review","volume":"170","author":"Abalos","year":"2013","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ajog.2023.01.013","article-title":"The 2017 American College of Cardiology and American Heart Association blood pressure categories in the second half of pregnancy\u2014A systematic review of their association with adverse pregnancy outcomes","volume":"229","author":"Slade","year":"2023","journal-title":"Am. J. Obstet Gynecol."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"American College of Obstetricians and Gynecologists (2020). Gestational Hypertension and Preeclampsia: ACOG Practice Bulletin, Number 222. Obstet. Gynecol., 135, e237\u2013e260.","DOI":"10.1097\/AOG.0000000000003891"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Minassian, C., Thomas, S.L., Williams, D.J., Campbell, O., and Smeeth, L. (2013). Acute maternal infection and risk of pre-eclampsia: A population-based case-control study. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0073047"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4137\/CMPed.S40070","article-title":"Intrauterine Growth Restriction: Antenatal and Postnatal Aspects","volume":"10","author":"Sharma","year":"2016","journal-title":"Clin. Med. Insights Pediatr."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3109\/14767050903121456","article-title":"Association of Helicobacter pylori infection with systemic inflammation in preeclampsia","volume":"23","author":"UstUn","year":"2010","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Reily-Bell, A.L., Fisher, A., Harrison, B., Bowie, S., Ray, S., Hawkes, M., Wise, L.M., Fukuzawa, R., Macaulay, E.C., and Devenish, C.J. (2020). Human Papillomavirus E6\/E7 Expression in Preeclampsia-Affected Placentae. Pathogens, 9.","DOI":"10.3390\/pathogens9030239"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Fetal Growth Restriction (2021). ACOG Practice Bulletin, Number 227. Obstet. Gynecol., 137, e16\u2013e28.","DOI":"10.1097\/AOG.0000000000004251"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1002\/uog.22134","article-title":"ISUOG Practice Guidelines: Diagnosis and management of small-for-gestational-age fetus and fetal growth restriction","volume":"56","author":"Lees","year":"2020","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/ijgo.13522","article-title":"FIGO (international Federation of Gynecology and obstetrics) initiative on fetal growth: Best practice advice for screening, diagnosis, and management of fetal growth restriction","volume":"152","author":"Melamed","year":"2021","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"114","DOI":"10.3345\/kjp.2018.61.4.114","article-title":"TORCH (toxoplasmosis, rubella, cytomegalovirus, and herpes simplex virus) screening of small for gestational age and intrauterine growth restricted neonates: Efficacy study in a single institute in Korea","volume":"61","author":"Chung","year":"2018","journal-title":"Korean J. Pediatr."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/pd.6073","article-title":"A systematic review of maternal TORCH serology as a screen for suspected fetal infection","volume":"42","author":"Fitzpatrick","year":"2022","journal-title":"Prenat. Diagn."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"868","DOI":"10.3855\/jidc.1533","article-title":"Adverse reproductive outcome induced by Parvovirus B19 and TORCH infections in women with high-risk pregnancy","volume":"5","author":"Kishore","year":"2011","journal-title":"J. Infect. Dev. Ctries."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.clp.2014.11.001","article-title":"TORCH infections","volume":"42","author":"Neu","year":"2015","journal-title":"Clin. Perinatol"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1038\/s41372-021-01157-9","article-title":"Primary cytomegalovirus infection during pregnancy and congenital infection: A population-based, mother-child, prospective cohort study","volume":"41","author":"Shimada","year":"2021","journal-title":"J. Perinatol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/pd.3843","article-title":"Fetal varicella\u2014Diagnosis, management, and outcome","volume":"32","author":"Mandelbrot","year":"2012","journal-title":"Prenat. Diagn."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Seitz, J., Morales-Prieto, D.M., Favaro, R.R., Schneider, H., and Markert, U.R. (2019). Molecular Principles of Intrauterine Growth Restriction in Plasmodium Falciparum Infection. Front. Endocrinol., 10.","DOI":"10.3389\/fendo.2019.00098"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1080\/14767058.2017.1378330","article-title":"Human papillomavirus infection and intrauterine growth restriction: A data-linkage study","volume":"32","author":"Ford","year":"2019","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"ref_80","unstructured":"(2024, May 07). Stillbirth Rate (per 1000 Total Births). Available online: https:\/\/www.who.int\/data\/gho\/data\/indicators\/indicator-details\/GHO\/stillbirth-rate-(per-1000-total-births)."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/S0140-6736(21)01112-0","article-title":"Global, regional, and national estimates and trends in stillbirths from 2000 to 2019: A systematic assessment","volume":"398","author":"Hug","year":"2021","journal-title":"Lancet"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/1471-0528.14906","article-title":"Risk of stillbirth, preterm delivery, and fetal growth restriction following exposure in a previous birth: Systematic review and meta-analysis","volume":"125","author":"Malacova","year":"2018","journal-title":"BJOG"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"(2020). Management of Stillbirth: Obstetric Care Consensus No, 10. Obstet. Gynecol., 135, e110\u2013e132.","DOI":"10.1097\/AOG.0000000000003719"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1097\/AOG.0000000000001247","article-title":"Evaluation of Human Papillomavirus as a Risk Factor for Preterm Birth or Pregnancy-Related Hypertension","volume":"127","author":"Subramaniam","year":"2016","journal-title":"Obstet. Gynecol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.siny.2015.12.008","article-title":"Infection and preterm birth","volume":"21","author":"Nadeau","year":"2016","journal-title":"Semin. Fetal Neonatal Med."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1097\/00003081-198809000-00006","article-title":"Infection and preterm labor","volume":"31","author":"Romero","year":"1988","journal-title":"Clin. Obstet. Gynecol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s00404-014-3471-6","article-title":"Pentoxifylline attenuates HPV-16 associated necrosis in placental trophoblasts","volume":"291","author":"Chen","year":"2015","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1023\/A:1007975005433","article-title":"Human papillomavirus is more prevalent in first trimester spontaneously aborted products of conception compared to elective specimens","volume":"14","author":"Hermonat","year":"1997","journal-title":"Virus Genes"},{"key":"ref_89","first-page":"25","article-title":"Defective 3A trophoblast-endometrial cell adhesion and altered 3A growth and survival by human papillomavirus type 16 oncogenes","volume":"1","author":"You","year":"2002","journal-title":"Mol. Cancer Res."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1093\/carcin\/bgp281","article-title":"Effects of HPV-16 E5, E6 and E7 proteins on survival, adhesion, migration and invasion of trophoblastic cells","volume":"31","author":"Boulenouar","year":"2010","journal-title":"Carcinogenesis"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.2147\/RMHP.S288838","article-title":"Prevalence of Human Papillomavirus and Genotype Distribution in Pregnant and Non-Pregnant Women in China","volume":"14","author":"Luo","year":"2021","journal-title":"Risk Manag. Healthc. Policy"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Nantel, \u00c9., Mayrand, M.-H., Audibert, F., Niyibizi, J., Brassard, P., Laporte, L., Lacaille, J., Zahreddine, M., Fraser, W., and Francoeur, D. (2024). Association between the Mode of Delivery and Vertical Transmission of Human Papillomavirus. Viruses, 16.","DOI":"10.3390\/v16020303"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1086\/498114","article-title":"High-risk types of human papillomavirus (HPV) DNA in oral and genital mucosa of infants during their first 3 years of life: Experience from the Finnish HPV Family Study","volume":"41","author":"Rintala","year":"2005","journal-title":"Clin. Infect. Dis."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/1743-422X-6-83","article-title":"Perinatal transmission of human papilomavirus DNA","volume":"6","author":"Rombaldi","year":"2009","journal-title":"Virol. J."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.rbmo.2019.10.019","article-title":"Human papillomavirus infection and female infertility: A systematic review and meta-analysis","volume":"40","author":"Yuan","year":"2020","journal-title":"Reprod. Biomed. Online"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/infdis\/jiaa106","article-title":"Has Human Papillomavirus (HPV) Vaccination Prevented Adverse Pregnancy Outcomes? Population-Level Analysis After 8 Years of a National HPV Vaccination Program in Australia","volume":"222","author":"Yuill","year":"2020","journal-title":"J. Infect. Dis."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"106473","DOI":"10.1016\/j.ypmed.2021.106473","article-title":"Preterm birth rate after bivalent HPV vaccination: Registry-based follow-up of a randomized clinical trial","volume":"146","author":"Kalliala","year":"2021","journal-title":"Prev. 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