{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T13:57:47Z","timestamp":1783432667284,"version":"3.54.6"},"reference-count":59,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Acute gastrointestinal bleeding (GIB) is one of the most common and dangerous condition in patients admitted in Emergency Departments. The incidence and the mortality of acute GIB remain significant, although some positive trends were observed in recent years. Initial evaluation of GIB needs an accurate assessment of the medical history and the clinical presentation. Physicians should pay attention about the presence of hemorrhagic shock that usually requires urgent diagnosis and treatment. Only a prompt diagnostic approach can identify the source of bleeding and improve the outcomes in acute GIB patients. Risk stratification and time of endoscopy are fundamental issues in the management of upper and lower GIB. Small bowel capsule enteroscopy (SBCE) and device-assisted enteroscopy (DAE) are the basic approaches to suspected small bowel bleeding. Machine Learning Prognostic Models have been proposed, such as alternative prognostic tools in GIB, but they are currently recommended only to identify low-risk outpatients.<\/jats:p>","DOI":"10.3390\/diagnostics16060860","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T12:59:44Z","timestamp":1773406784000},"page":"860","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Acute Gastrointestinal Bleeding: An Update and a Practical Diagnostic Approach"],"prefix":"10.3390","volume":"16","author":[{"given":"Elio","family":"Antonucci","sequence":"first","affiliation":[{"name":"Intermediate Care Unit, Emergency and Intensive Care Medicine Department, Ospedale Guglielmo da Saliceto, 29121 Piacenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Zanichelli","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, ASST Grande Ospedale Metropolitano Niguarda, 20162 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0222-7706","authenticated-orcid":false,"given":"Alessandro","family":"Rimondi","sequence":"additional","affiliation":[{"name":"Interventional Digestive Endoscopy, ASST Spedali Civili di Brescia, 25123 Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"101639","DOI":"10.5492\/wjccm.v14.i1.101639","article-title":"Management of gastrointestinal bleed in the intensive care setting, an updated literature review","volume":"14","author":"Nagesh","year":"2025","journal-title":"World J. Crit. Care Med."},{"key":"ref_2","unstructured":"Antunes, C., and Tian, C. (2025). Upper Gastrointestinal Bleeding. StatPearls, StatPearls Publishing."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1055\/a-1369-5274","article-title":"Endoscopic diagnosis and management of nonvariceal upper gastrointestinal hemorrhage (NVUGIH): European Society of Gastrointestinal Endoscopy (ESGE) Guideline\u2014Update 2021","volume":"53","author":"Gralnek","year":"2021","journal-title":"Endoscopy"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"899","DOI":"10.14309\/ajg.0000000000001245","article-title":"ACG Clinical Guideline: Upper Gastrointestinal and Ulcer Bleeding","volume":"1","author":"Laine","year":"2021","journal-title":"Am. J. Gastroenterol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1067\/mge.2001.112181","article-title":"Total enteroscopy with a nonsurgical steerable double-balloon method","volume":"53","author":"Yamamoto","year":"2001","journal-title":"Gastrointest. Endosc."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/35013140","article-title":"Wireless capsule endoscopy","volume":"405","author":"Iddan","year":"2000","journal-title":"Nature"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"208","DOI":"10.14309\/ajg.0000000000002130","article-title":"Management of Patients With Acute Lower Gastrointestinal Bleeding: An Updated ACG Guideline","volume":"118","author":"Sengupta","year":"2023","journal-title":"Am. J. Gastroenterol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1055\/a-1496-8969","article-title":"Diagnosis and management of acute lower gastrointestinal bleeding: European Society of Gastrointestinal Endoscopy (ESGE) Guideline","volume":"53","author":"Triantafyllou","year":"2021","journal-title":"Endoscopy"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1055\/a-1973-3796","article-title":"Small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and treatment of small-bowel disorders: European Society of Gastrointestinal Endoscopy (ESGE) Guideline\u2014Update 2022","volume":"55","author":"Pennazio","year":"2023","journal-title":"Endoscopy"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1053\/j.gastro.2021.10.017","article-title":"Burden and Cost of Gastrointestinal, Liver and Pancreatic Diseases in the United States: Update 2021","volume":"162","author":"Peery","year":"2022","journal-title":"Gastroenterology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1007\/s10620-017-4882-6","article-title":"Changing Epidemiology of Upper Gastrointestinal Hemorrhage in the Last Decade: A Nationwide Analysis","volume":"63","author":"Wuerth","year":"2018","journal-title":"Dig. Dis. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1093\/jcag\/gwac010","article-title":"American College of Gastroenterology\u2014Canadian Association of Gastroenterology Clinical Practice Guideline: Management of Anticoagulants and Antiplatelets During Acute Gastrointestinal Bleeding and the Periendoscopic Period","volume":"5","author":"Abraham","year":"2022","journal-title":"J. Can. Assoc. Gastroenterol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1038\/ajg.2012.168","article-title":"Trends for incidence of hospitalization and death due to GI complications in the United States from 2001 to 2009","volume":"107","author":"Laine","year":"2012","journal-title":"Am. J. Gastroenterol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1111\/j.1572-0241.2008.01865.x","article-title":"Predictive factors of mortality from nonvariceal upper gastrointestinal hemorrhage: A multicenter study","volume":"103","author":"Marmo","year":"2008","journal-title":"Am. J. Gastroenterol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jviscsurg.2014.03.008","article-title":"The management of lower gastrointestinal bleeding","volume":"151","author":"Marion","year":"2014","journal-title":"J. Visc. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.cgh.2014.06.023","article-title":"Recurrence and mortality among patients hospitalized for acute lower gastrointestinal bleeding","volume":"13","author":"Aoki","year":"2015","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1038\/ajg.2009.164","article-title":"Time trends and impact of upper and lower gastrointestinal bleeding and perforation in clinical practice","volume":"104","author":"Lanas","year":"2009","journal-title":"Am. J. Gastroenterol."},{"key":"ref_18","first-page":"12","article-title":"Clinical approach to the patient with acute gastrointestinal bleeding","volume":"89","author":"Gaiani","year":"2018","journal-title":"Acta Biomed."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1056\/NEJMra1208943","article-title":"Circulatory Shock","volume":"369","author":"Vincent","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1097\/01.CCM.0000201896.45809.E3","article-title":"Does dopamine administration in shock influence outcome? Results of the Sepsis Occurrence in Acutely Ill Patients (SOAP) Study","volume":"34","author":"Sakr","year":"2006","journal-title":"Crit. Care Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e000202","DOI":"10.1136\/bmjmed-2022-000202","article-title":"Update on the management of upper gastrointestinal bleeding","volume":"1","author":"Stanley","year":"2022","journal-title":"BMJ Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"goad011","DOI":"10.1093\/gastro\/goad011","article-title":"An update of the management of non-variceal upper gastrointestinal bleeding","volume":"11","author":"Alali","year":"2023","journal-title":"Gastroenterol. Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"i6432","DOI":"10.1136\/bmj.i6432","article-title":"Comparison of risk scoring systems for patients presenting with upper gastrointestinal bleeding: International multicentre prospective study","volume":"356","author":"Stanley","year":"2017","journal-title":"BMJ"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"101613","DOI":"10.1016\/j.bpg.2019.04.006","article-title":"Risk stratification in upper and upper and lower GI bleeding: Which scores should we use?","volume":"42","author":"Oakland","year":"2019","journal-title":"Best. Pr. Res. Clin. Gastroenterol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1016\/S0140-6736(00)02816-6","article-title":"A risk score to predict need for treatment for upper gastrointestinal haemorrhage","volume":"356","author":"Blatchford","year":"2000","journal-title":"Lancet"},{"key":"ref_26","first-page":"15","article-title":"Evaluating The Glasgow Blatchford Score for Upper Gastrointestinal Bleeding Risk Stratification in A Community Hospital: A Retrospective Study","volume":"1","author":"Neamah","year":"2025","journal-title":"Spartan Med. Res. J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1016\/j.gie.2010.01.028","article-title":"Comparing the Blatchford and pre-endoscopic Rockall score in predicting the need for endoscopic therapy in patients with upper GI hemorrhage","volume":"71","author":"Pang","year":"2010","journal-title":"Gastrointest. Endosc."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1136\/gut.38.3.316","article-title":"Risk assessment after acute upper gastrointestinal haemorrhage","volume":"38","author":"Rockall","year":"1996","journal-title":"Gut"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/j.gie.2011.06.024","article-title":"A simple risk score accurately predicts in-hospital mortality, length of stay, and cost in acute upper GI bleeding","volume":"74","author":"Saltzman","year":"2011","journal-title":"Gastrointest. Endosc."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1007\/s12664-023-01387-z","article-title":"AIMS65, Glasgow-Blatchford bleeding score and modified Glasgow-Blatchford bleeding score in predicting outcomes of upper gastrointestinal bleeding: An accuracy and calibration study","volume":"42","author":"Thulaseedharan","year":"2023","journal-title":"Indian J. Gastroenterol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e2529746","DOI":"10.1001\/jamanetworkopen.2025.29746","article-title":"Computed Tomographic Angiography and Yield for Gastrointestinal Bleeding in the Emergency Department","volume":"8","author":"Prasad","year":"2025","journal-title":"JAMA Netw. Open"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"805","DOI":"10.7326\/M19-1795","article-title":"Management of nonvariceal upper gastrointestinal bleeding: Guideline recommendations from the International Consensus Group","volume":"171","author":"Barkun","year":"2019","journal-title":"Ann. Intern. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1056\/NEJMoa1912484","article-title":"Timing of endoscopy for acute upper gastrointestinal bleeding","volume":"382","author":"Lau","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1055\/a-1939-4887","article-title":"Endoscopic diagnosis and management of esophagogastric variceal hemorrhage: European Society of Gastrointestinal Endoscopy (ESGE) Guideline","volume":"54","author":"Gralnek","year":"2022","journal-title":"Endoscopy"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"569","DOI":"10.5009\/gnl20222","article-title":"Gastrointestinal and Nongastrointestinal Complications of Esophagogastroduodenoscopy and Colonoscopy in the Real World: A Nationwide Standard Cohort Using the Common Data Model Database","volume":"15","author":"Kim","year":"2021","journal-title":"Gut Liver"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/s00464-024-11370-0","article-title":"Clinical features and risk factors for colorectal gas explosion during digestive endoscopy and surgery: A systematic review","volume":"39","author":"Tontini","year":"2025","journal-title":"Surg. Endosc."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1053\/j.gastro.2019.09.010","article-title":"Efficacy and Safety of Early vs Elective Colonoscopy for Acute Lower Gastrointestinal Bleeding","volume":"158","author":"Niikura","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.gie.2022.07.025","article-title":"Timing of colonoscopy in acute lower GI bleeding: A multicenter retrospective cohort study","volume":"97","author":"Shiratori","year":"2023","journal-title":"Gastrointest. Endosc."},{"key":"ref_39","first-page":"654","article-title":"Acute lower GI bleeding in the UK: Patient characteristics, interventions and outcomes in the first nationwide audit","volume":"67","author":"Oakland","year":"2018","journal-title":"Gut"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e209630","DOI":"10.1001\/jamanetworkopen.2020.9630","article-title":"External Validation of the Oakland Score to Assess Safe Hospital Discharge Among Adult Patients With Acute Lower Gastrointestinal Bleeding in the US","volume":"1","author":"Oakland","year":"2020","journal-title":"JAMA Netw. Open"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.1007\/s00330-024-11102-x","article-title":"Trans-arterial embolization for treatment of acute lower gastrointestinal bleeding-a multicenter analysis","volume":"35","author":"Hosse","year":"2025","journal-title":"Eur. Radiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1093\/bjr\/tqae037","article-title":"Twenty years of embolization for acute lower gastrointestinal bleeding: A meta-analysis of rebleeding and ischaemia rates","volume":"97","author":"Yu","year":"2024","journal-title":"Br. J. Radiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/j.surg.2023.03.003","article-title":"The use of surgical intervention for lower gastrointestinal bleeding and its association with clinical outcomes and resource use","volume":"173","author":"Lee","year":"2023","journal-title":"Surgery"},{"key":"ref_44","first-page":"419","article-title":"Epidemiology and outcome of patients hospitalized with acute lower gastrointestinal hemorrhage: A population-based study","volume":"92","author":"Longstreth","year":"1997","journal-title":"Am. J. Gastroenterol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1111\/j.1440-1746.2010.06530.x","article-title":"Double balloon enteroscopy and capsule endoscopy for obscure gastrointestinal bleeding: An updated meta-analysis","volume":"26","author":"Teshima","year":"2011","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1053\/j.gastro.2016.12.032","article-title":"Clinical Practice Guidelines for the Use of Video Capsule Endoscopy","volume":"152","author":"Enns","year":"2017","journal-title":"Gastroenterology"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/den.13554","article-title":"Management of obscure gastrointestinal bleeding: Comparison of guidelines between Japan and other countries","volume":"32","author":"Ohmiya","year":"2020","journal-title":"Dig. Endosc."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/den.12883","article-title":"Clinical Practice Guideline for Enteroscopy","volume":"29","author":"Yamamoto","year":"2017","journal-title":"Dig. Endosc."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.gie.2008.06.035","article-title":"Significant small-bowel lesions detected by alternative diagnostic modalities after negative capsule endoscopy","volume":"68","author":"Postgate","year":"2008","journal-title":"Gastrointest. Endosc."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.gie.2021.12.009","article-title":"Diagnostic and therapeutic yields of early capsule endoscopy and device-assisted enteroscopy in the setting of overt GI bleeding: A systematic review with meta-analysis","volume":"95","author":"Estevinho","year":"2022","journal-title":"Gastrointest. Endosc."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"E122","DOI":"10.1055\/a-1319-0742","article-title":"Quality performance measures for small capsule endoscopy: Are the ESGE quality standards met?","volume":"9","author":"Rondonotti","year":"2021","journal-title":"Endosc. Int. Open"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Kametaka, D., and Iwamuro, M. (2025). A study on the timing of small-bowel capsule endoscopy and its impact on the detection rate of bleeding sources. BMC Gastroenterol., 25.","DOI":"10.1186\/s12876-025-04044-1"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Czajka, S., and Zi\u0119bi\u0144ska, K. (2020). Validation of APACHE II, APACHE III and SAPS II scores in in-hospital and one year mortality pre-diction in a mixed intensive care unit in Poland: A cohort study. BMC Anesth., 20.","DOI":"10.1186\/s12871-020-01203-7"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.14309\/ajg.0000000000000720","article-title":"Machine Learning Prognostic Models for Gastrointestinal Bleeding Using Electronic Health Record Data","volume":"115","author":"Shung","year":"2020","journal-title":"Am. J. Gastroenterol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"E774","DOI":"10.1055\/a-0880-5312","article-title":"Novel telemetric sensor capsule for EGD urgency triage: A feasibility study","volume":"7","author":"Schmidt","year":"2019","journal-title":"Endosc. Int. Open"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.gie.2023.11.051","article-title":"A novel blood-sensing capsule for rapid detection of upper GI bleeding: A prospective clinical trial","volume":"99","author":"Akiki","year":"2024","journal-title":"Gastrointest. Endosc."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"E1852","DOI":"10.1055\/a-1578-1800","article-title":"Applicability of colon capsule endoscopy as panendoscopy: From bowel preparation, transit- and rating times to completion rate and patient acceptance","volume":"9","author":"Vuik","year":"2021","journal-title":"Endosc. Intern. Open"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"E1860","DOI":"10.1055\/a-1548-6572","article-title":"Colon capsule for panendoscopy: A narrow window of opportunity","volume":"9","author":"Rondonotti","year":"2021","journal-title":"Endosc. Int. Open"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1097\/MEG.0000000000002200","article-title":"Clinical feasibility of panintestinal (or panenteric) capsule endoscopy: A systematic review","volume":"33","author":"Elosua","year":"2021","journal-title":"Eur. J. Gastroenterol. 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