{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T11:18:04Z","timestamp":1773746284000,"version":"3.50.1"},"reference-count":5,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>A 75-year-old man with newly diagnosed high-risk prostate cancer (cT3bN0M0) underwent 18F-PSMA PET\/CT, which demonstrated intense tracer uptake in a left tracheal mass causing near-complete luminal obstruction, raising suspicion of a primary lung malignancy or metastatic disease. Endoscopic debulking was performed due to progressive respiratory symptoms with dyspnea. Histopathology and immunohistochemistry (p63, SMA, CK5\/6 positive; PSA, NKX3.1, and AR negative, with downregulated PSMA-expression) established the diagnosis of low-grade epithelial\u2013myoepithelial carcinoma of the trachea. Following debulking, the patient\u2019s symptoms resolved, and a watchful-waiting strategy was adopted for the tracheal tumor, while curative-intent therapy for prostate cancer continued. This case highlights that 18F-PSMA PET\/CT may reveal rare, intensely PSMA-avid non-prostatic neoplasms and underscores the importance of recognizing atypical uptake patterns to avoid misinterpretation during prostate cancer staging.<\/jats:p>","DOI":"10.3390\/diagnostics16060883","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T10:21:41Z","timestamp":1773742901000},"page":"883","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pretherapeutic 18F-PSMA PET\/CT Reveals Incidental Tracheal Epithelial\u2013Myoepithelial Carcinoma"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4029-3197","authenticated-orcid":false,"given":"Farid","family":"Gossili","sequence":"first","affiliation":[{"name":"Department of Clinical Physiology, Viborg Regional Hospital, 8800 Viborg, Denmark"},{"name":"Department of Clinical Medicine, Aalborg University, 9220 Aalborg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelson","family":"Fuentes-Martinez","sequence":"additional","affiliation":[{"name":"Department of Pathology, Aarhus University Hospital, 8200 Arhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0491-1680","authenticated-orcid":false,"given":"Christian","family":"H\u00f8yer","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Viborg Regional Hospital, 8800 Viborg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,16]]},"reference":[{"key":"ref_1","first-page":"241","article-title":"Prostate-specific membrane antigen as a target for cancer imaging and therapy","volume":"59","author":"Kiess","year":"2015","journal-title":"Q. J. Nucl. Med. Mol. Imaging"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1002\/pros.21090","article-title":"Three conformational antibodies specific for different PSMA epitopes are promising diagnostic and therapeutic tools for prostate cancer","volume":"70","author":"Wolf","year":"2010","journal-title":"Prostate"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1007\/s13139-016-0445-6","article-title":"68Ga-PSMA PET-CT Imaging of Metastatic Adenoid Cystic Carcinoma","volume":"51","author":"Krijger","year":"2017","journal-title":"Nucl. Med. Mol. Imaging"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1097\/RLU.0000000000001220","article-title":"In Vivo Visualization of Prostate-Specific Membrane Antigen in Adenoid Cystic Carcinoma of the Salivary Gland","volume":"41","author":"Lutje","year":"2016","journal-title":"Clin. Nucl. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1007\/s00259-017-3737-x","article-title":"Prostate-specific membrane antigen PET imaging and immunohistochemistry in adenoid cystic carcinoma-a preliminary analysis","volume":"44","author":"Krijger","year":"2017","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/6\/883\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T10:33:20Z","timestamp":1773743600000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/6\/883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,16]]},"references-count":5,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["diagnostics16060883"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics16060883","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,16]]}}}