{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T16:56:35Z","timestamp":1774284995117,"version":"3.50.1"},"reference-count":30,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: Acromegaly is a systemic connective tissue disease driven by chronic growth hormone (GH) and insulin-like growth factor-1 (IGF-1) excess; yet, the female reproductive tract\u2014especially the extracellular matrix (ECM)-rich cervix\u2014has been poorly studied. We aimed to compare uterine and cervical morphology in women with acromegaly versus healthy controls and a gynecologic disease comparator, testing the hypothesis of selective cervical hypertrophy. Methods: We performed a retrospective case\u2013control study of reproductive-age women who underwent pelvic ultrasound: acromegaly (n = 33), healthy controls (n = 45), and adenomyosis without acromegaly (n = 44). Uterine body measurements were obtained by TAUS\/TVUS; cervical biometry was performed transvaginally in all cases. Volumes were estimated using the ellipsoid formula, and a uterus-to-cervix (U:C) volume ratio was calculated. Group differences were analyzed with Mann\u2013Whitney tests and Bonferroni correction. Results: A total of 122 women were included. Uterine body length, width, AP size, and volume did not differ between acromegaly and either comparison group (all p-values non-significant). In contrast, cervical length, width, AP thickness, and volume were significantly higher in acromegaly than in healthy controls, with a corresponding reduction in the U:C volume ratio, indicating disproportionate cervical enlargement. Compared with adenomyosis, women with acromegaly again showed larger cervical width, AP thickness, and volume, together with altered U:C indices, whereas cervical length did not differ, suggesting a pattern not explained by nonspecific pelvic pathology. Conclusions: Women with acromegaly demonstrate a distinct uterine phenotype characterized by selective cervical hypertrophy with preserved uterine corpus size\u2014an ECM-centric \u201cacromegalic uteropathy.\u201d This noninvasive morphometric signature may have diagnostic and procedural relevance and warrants confirmation in prospective studies.<\/jats:p>","DOI":"10.3390\/diagnostics16060956","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T15:54:53Z","timestamp":1774281293000},"page":"956","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acromegalic Uteropathy: Specific Uterine Ultrasound Findings in Female Patients"],"prefix":"10.3390","volume":"16","author":[{"given":"Irina","family":"Stanoevich","sequence":"first","affiliation":[{"name":"Endocrinology Research Centre, 11 Dmitriya Ulyanova St., Moscow 117036, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurika","family":"Asanova","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre, 11 Dmitriya Ulyanova St., Moscow 117036, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana","family":"Vorotnikova","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre, 11 Dmitriya Ulyanova St., Moscow 117036, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrey","family":"Belov","sequence":"additional","affiliation":[{"name":"Regional Budgetary Healthcare Institution \u201cKursk Oblast Scientific and Clinical Center named after G. E. Ostroverkhov\u201d, 1 Eliseeva St., Kislino Khutor, Kursky District 305524, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekaterina","family":"Grezina","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre, 11 Dmitriya Ulyanova St., Moscow 117036, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulia","family":"Fedorova","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Pirogov Russian National Research Medical University, 1 Ostrovityanova St., Bldg. 6, Moscow 117997, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ugljesa","family":"Stanojevic","sequence":"additional","affiliation":[{"name":"Regional Budgetary Healthcare Institution \u201cKursk Oblast Scientific and Clinical Center named after G. E. Ostroverkhov\u201d, 1 Eliseeva St., Kislino Khutor, Kursky District 305524, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0327-4619","authenticated-orcid":false,"given":"Larisa","family":"Dzeranova","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre, 11 Dmitriya Ulyanova St., Moscow 117036, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekaterina","family":"Pigarova","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre, 11 Dmitriya Ulyanova St., Moscow 117036, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Galina","family":"Melnichenko","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre, 11 Dmitriya Ulyanova St., Moscow 117036, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalya","family":"Mokrysheva","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre, 11 Dmitriya Ulyanova St., Moscow 117036, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/S2213-8587(22)00244-3","article-title":"Acromegaly: Pathogenesis, diagnosis, and management","volume":"10","author":"Fleseriu","year":"2022","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1515\/med-2020-0216","article-title":"IGF-1 regulates the growth of fibroblasts and extracellular matrix deposition in pelvic organ prolapse","volume":"15","author":"Yin","year":"2020","journal-title":"Open Med."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Miescher, I., Rieber, J., Calcagni, M., and Buschmann, J. 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