{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:28:15Z","timestamp":1791923295254,"version":"4.3.4"},"reference-count":40,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: Thrombosis in light chain amyloidosis (LCA) occurs in the context of multiple organ dysfunction and inflammation. Conventional coagulation tests (screening) may not sufficiently capture the procoagulant substrate in the inflammatory\/therapeutic dynamics. Methods: A total of 61 consecutive patients with LCA were prospectively included in the study. Clinical data, including organ involvement, time of diagnosis, treatment phase, DOAC exposure and thrombosis history were systematically recorded and subjected to screening. Specialized hemostasis tests such as APTT\/PT, fibrinogen, D-dimer, TEG and TGT were performed and conventional times were analyzed in the subgroup without DOAC. Results: The prevalence of documented thrombosis was 32.8%, and thrombosis status was associated with TEG positivity and more strongly with TGT positivity. Hypercoagulability was identified in 50.8% by TEG and 41.0% by TGT, regardless of whether APTT\/PT were within the reference values. APTT\/PT did not predict thrombosis recurrence (p &gt; 0.05), which was predicted by TEG (p = 0.0027) and TGT (p = 0.0006). An inflammation\/fibrin turnover panel (CRP, fibrinogen, D-dimer) predicted TEG positivity (p &lt; 0.0001), but not TGT, and was correlated with assessment at diagnosis, daratumumab-based therapy, and cardiac involvement. Conclusions: Global tests (TEG\/TGT) promptly correlate with thrombosis recurrence in our cohort and provide crucial information in addition to clotting times for thrombotic phenotyping. Inflammation can influence TEG, so the decision to recommend the tests and the timing of their performance should be adapted to the clinical, biological, and therapeutic context.<\/jats:p>","DOI":"10.3390\/diagnostics16070987","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T13:57:34Z","timestamp":1774447054000},"page":"987","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hypercoagulability in Light Chain Amyloidosis and the Importance of Predictive Value of TEG and TGT for Thrombosis Recurrence in Inflammatory States"],"prefix":"10.3390","volume":"16","author":[{"given":"Mihai Emanuel","family":"Himcinschi","sequence":"first","affiliation":[{"name":"Haematology and Bone Marrow Transplant Centre, Clinical Institute Fundeni, 022328 Bucharest, Romania"},{"name":"Haematology Department, University of Medicine and Pharmacy Carol Davila, 020021 Bucharest, Romania"},{"name":"Department of Biochemistry, Victor Babes University of Medicine and Pharmacy, 300041 Timi\u015foara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela","family":"Uta","sequence":"additional","affiliation":[{"name":"Haematology and Bone Marrow Transplant Centre, Clinical Institute Fundeni, 022328 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreea","family":"Jercan","sequence":"additional","affiliation":[{"name":"Haematology and Bone Marrow Transplant Centre, Clinical Institute Fundeni, 022328 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3208-2108","authenticated-orcid":false,"given":"Daniel","family":"Murariu","sequence":"additional","affiliation":[{"name":"Haematology and Bone Marrow Transplant Centre, Clinical Institute Fundeni, 022328 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delia Codruta","family":"Popa","sequence":"additional","affiliation":[{"name":"Haematology and Bone Marrow Transplant Centre, Clinical Institute Fundeni, 022328 Bucharest, Romania"},{"name":"Haematology Department, University of Medicine and Pharmacy Carol Davila, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Uscatescu","sequence":"additional","affiliation":[{"name":"Haematology and Bone Marrow Transplant Centre, Clinical Institute Fundeni, 022328 Bucharest, Romania"},{"name":"Haematology Department, University of Medicine and Pharmacy Carol Davila, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei","family":"Anghel","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Victor Babes University of Medicine and Pharmacy, 300041 Timi\u015foara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7251-6079","authenticated-orcid":false,"given":"Daniel","family":"Coriu","sequence":"additional","affiliation":[{"name":"Haematology and Bone Marrow Transplant Centre, Clinical Institute Fundeni, 022328 Bucharest, Romania"},{"name":"Haematology Department, University of Medicine and Pharmacy Carol Davila, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1507-2547","authenticated-orcid":false,"given":"Sorina Nicoleta","family":"Badelita","sequence":"additional","affiliation":[{"name":"Haematology and Bone Marrow Transplant Centre, Clinical Institute Fundeni, 022328 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/s41408-021-00486-4","article-title":"Comprehensive Review of AL amyloidosis: Some practical recommendations","volume":"11","author":"Bazarbachi","year":"2021","journal-title":"Blood Cancer J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e12284","DOI":"10.1590\/1414-431x2022e12284","article-title":"Renal amyloidosis: A new time for a complete diagnosis","volume":"55","author":"Feitosa","year":"2022","journal-title":"Braz. 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