{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T04:53:55Z","timestamp":1775710435038,"version":"3.50.1"},"reference-count":120,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Fetal MRI has been increasingly used in diagnosis and assessment of congenital anomalies and conditions by providing detailed structural information. However, such information is only part of the whole landscape of these genetic disorders. Given that genetic disorders are associated with significant morbidity and mortality in infants, multidisciplinary team management is essential for perinatal management and parental counseling. In the past two decades, there are advances in both fetal MRI and genetic testing for prenatal diagnosis of genetic disorders. This narrative review consolidates the current literature and aims to provide a systematic overview of fetal MRI applications in genetic disorders affecting the central nervous system, craniofacial structures, skeletal system, lungs, and urinary system. Understanding embryological and genetic basis as well as imaging phenotypes of genetic disorders are important in improving perinatal diagnosis and management.<\/jats:p>","DOI":"10.3390\/diagnostics16071112","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T07:25:12Z","timestamp":1775633112000},"page":"1112","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetic Disorders Detectable by Fetal MRI: A Review"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4946-7748","authenticated-orcid":false,"given":"Kwok Chun","family":"Wong","sequence":"first","affiliation":[{"name":"Department of Radiology, Hong Kong Children\u2019s Hospital, Kowloon Bay, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4567-5562","authenticated-orcid":false,"given":"Tsz Ho","family":"Chow","sequence":"additional","affiliation":[{"name":"Department of Imaging and Interventional Radiology, Prince of Wales Hospital, Shatin, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Cheung","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hong Kong Children\u2019s Hospital, Kowloon Bay, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3207-5704","authenticated-orcid":false,"given":"Joyce Pui Kwan","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hong Kong Children\u2019s Hospital, Kowloon Bay, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonan Chun Yin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Queen Elizabeth Hospital, Jordan, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6839-6000","authenticated-orcid":false,"given":"Elaine Yee Ling","family":"Kan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hong Kong Children\u2019s Hospital, Kowloon Bay, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4962-4132","authenticated-orcid":false,"given":"Winnie Chiu Wing","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Imaging and Interventional Radiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41525-020-00155-8","article-title":"Measurement of Genetic Diseases as a Cause of Mortality in Infants Receiving Whole Genome Sequencing","volume":"5","author":"Kingsmore","year":"2020","journal-title":"npj Genom. 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