{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T13:52:19Z","timestamp":1776865939552,"version":"3.51.2"},"reference-count":31,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Recep Tayyip Erdo\u011fan University Development Foundation","award":["02026002013106"],"award-info":[{"award-number":["02026002013106"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: The relationship between P-wave dispersion (Pd) and disease status in patients with Familial Mediterranean Fever (FMF) undergoing colchicine treatment is unclear in the literature, and results are contradictory. This study aimed to evaluate P-wave dispersion in patients with Familial Mediterranean Fever receiving regular long-term colchicine treatment and to compare these findings with those of age- and sex-matched individuals without FMF. Methods: A cross-sectional and observational study included 97 individuals with positive FMF and 97 individuals with negative FMF. FMF diagnosis was confirmed according to the Tel-HaShomer criteria, and all patients received regular colchicine treatment and were evaluated during the attack-free period. P maximum, P minimum, and Pd were measured using standard 12-lead electrocardiography (ECG); clinical, laboratory, and drug data were recorded. Pd associations were analyzed using correlation and multivariable regression. Results: Pd was found to be significantly higher in FMF (+) patients (47 vs. 39 ms, p &lt; 0.001). Pd showed a positive correlation with FMF status (r = 0.508, p &lt; 0.001), colchicine dose (r = 0.476, p &lt; 0.001), white blood cell (WBC) (r = 0.209, p = 0.005) and high-density lipoprotein cholesterol (HDL-C) (r = 0.156, p = 0.037) and a negative correlation with calcium channel blocker use (r = \u22120.245, p = 0.001). In multivariate analysis, FMF increased Pd by 10.17 ms, while calcium channel blockers decreased it by 11.78 ms (p &lt; 0.001). Age, WBC and HDL-C also had independent positive effects on Pd (p &lt; 0.001, p = 0.017, p = 0.040, respectively). Conclusions: These findings suggest that FMF is associated with increased P-wave dispersion despite regular colchicine treatment, indicating persistent subclinical atrial conduction heterogeneity.<\/jats:p>","DOI":"10.3390\/diagnostics16091252","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T12:54:08Z","timestamp":1776862448000},"page":"1252","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Familial Mediterranean Fever and P-Wave Dispersion Under Colchicine Treatment"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5272-6451","authenticated-orcid":false,"given":"Osman","family":"C\u00fcre","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Faculty of Medicine, Recep Tayyip Erdo\u011fan University, 53020 Rize, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8248-5966","authenticated-orcid":false,"given":"H\u00fcseyin","family":"Durak","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine, Recep Tayyip Erdo\u011fan University, 53020 Rize, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"\u00c7etin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine, Recep Tayyip Erdo\u011fan University, 53020 Rize, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bayram","family":"K\u0131z\u0131lkaya","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Training and Research Hospital, Recep Tayyip Erdo\u011fan University, 53020 Rize, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.5152\/TurkArchPediatr.2024.24188","article-title":"Familial Mediterranean Fever in Childhood","volume":"59","author":"Akay","year":"2024","journal-title":"Turk. Arch. Pediatr."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s13023-024-03098-w","article-title":"Updates on the role of epigenetics in familial mediterranean fever (FMF)","volume":"19","author":"Chaaban","year":"2024","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1093\/rheumatology\/kead439","article-title":"Old paradigms and new concepts in familial Mediterranean fever (FMF): An update 2023","volume":"63","year":"2024","journal-title":"Rheumatology"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"El Roz, A., Ghssein, G., Khalaf, B., Fardoun, T., and Ibrahim, J.N. (2020). Spectrum of MEFV Variants and Genotypes among Clinically Diagnosed FMF Patients from Southern Lebanon. Med. Sci., 8.","DOI":"10.3390\/medsci8030035"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s41232-022-00217-7","article-title":"Autoinflammatory disease: Clinical perspectives and therapeutic strategies","volume":"42","author":"Kawakami","year":"2022","journal-title":"Inflamm. Regen."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4274\/balkanmedj.galenos.2025.2025-11-133","article-title":"Familial Mediterranean Fever: A Comprehensive Review of Pathogenesis, Genetics, and Epigenetic Regulation","volume":"43","author":"Ugurlu","year":"2026","journal-title":"Balk. Med. J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s00296-017-3853-8","article-title":"Cardiac disease in familial Mediterranean fever","volume":"38","author":"Erken","year":"2018","journal-title":"Rheumatol. Int."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.amjmed.2026.01.006","article-title":"Familial Mediterranean Fever and Long-Term Cardiovascular Disease Burden","volume":"139","author":"Magen","year":"2026","journal-title":"Am. J. Med."},{"key":"ref_9","first-page":"e30585","article-title":"Relation Between Familial Mediterranean Fever and QT Markers (QTc, QTd, and QTcd): A Systematic Review and Meta-Analysis","volume":"14","author":"Motawea","year":"2022","journal-title":"Cureus"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.ipej.2016.10.002","article-title":"P-wave dispersion: An update","volume":"16","author":"Grindler","year":"2016","journal-title":"Indian Pacing Electrophysiol. J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s43044-024-00503-4","article-title":"Study of P wave dispersion in patients with paroxysmal atrial fibrillation and its role in prediction of atrial fibrillation recurrence","volume":"76","author":"Gomaa","year":"2024","journal-title":"Egypt. Heart J."},{"key":"ref_12","first-page":"5","article-title":"Utility of P-Wave Dispersion in the Prediction of Atrial Fibrillation","volume":"43","author":"Donoiu","year":"2017","journal-title":"Curr. Health Sci. J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1007\/s00393-019-0642-7","article-title":"Colchicine\u2019s Effects on Electrocardiographic Parameters in Newly Diagnosed Familial Mediterranean Fever Patients: Colchicine may have Favourable Effects on Parameters Related to Ventricular Arrhythmias in New Diagnosed Familial Mediterranean Fever","volume":"79","author":"Ocal","year":"2020","journal-title":"Z. Rheumatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12969-022-00696-5","article-title":"Cardiac repolarization abnormalities in children with familial Mediterranean fever","volume":"20","author":"Farag","year":"2022","journal-title":"Pediatr. Rheumatol. Online J."},{"key":"ref_15","first-page":"3427","article-title":"P wave and QT dispersion in familial mediterranean fever","volume":"20","author":"Kirbas","year":"2016","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_16","first-page":"e35120","article-title":"The Effect of Colchicine on Atrial Fibrillation: A Systematic Review and Meta-Analysis","volume":"15","author":"Kommu","year":"2023","journal-title":"Cureus"},{"key":"ref_17","first-page":"2048004016639443","article-title":"P-wave dispersion: What we know till now?","volume":"5","author":"Okutucu","year":"2016","journal-title":"JRSM Cardiovasc. Dis."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"401","DOI":"10.11124\/JBIES-24-00523","article-title":"The revised JBI critical appraisal tool for the assessment of risk of bias for analytical cross-sectional studies","volume":"24","author":"Barker","year":"2026","journal-title":"JBI Evid. Synth."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3940","DOI":"10.1093\/rheumatology\/kead153","article-title":"Increased risk for stroke in patients with familial Mediterranean fever: Results from a large population-based study","volume":"62","author":"Gendelman","year":"2023","journal-title":"Rheumatology"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Sav, N.M., Altinsoy, H.B., Turen, B., and G\u00f6k\u00e7e, A. (2025). Arterial Stiffness and Subclinical Inflammation in Children with Familial Mediterranean Fever: A Comprehensive Analysis. Children, 12.","DOI":"10.3390\/children12020232"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1007\/s10067-016-3532-2","article-title":"Evaluation of endothelial dysfunction in patients with familial Mediterranean fever: The relationship between the levels of asymmetric dimethylarginine and endocan with carotid intima-media thickness and endothelium-dependent vasodilation","volume":"36","author":"Ozalper","year":"2017","journal-title":"Clin. Rheumatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1038\/s41390-024-03093-8","article-title":"Serum endocan, asymmetric dimethylarginine and lipid profile in children with familial Mediterranean fever","volume":"97","author":"Hassan","year":"2025","journal-title":"Pediatr. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.7150\/ijms.9444","article-title":"P wave dispersion and QT dispersion in adult Turkish migrants with familial mediterranean fever living in Germany","volume":"11","author":"Giese","year":"2014","journal-title":"Int. J. Med. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Jaber, N., Khalil, M., Abdallah, H., Mahdi, L., Giordano, V., Daher, A., Shamesseddin, F., Ghssein, G., Resta, N., and Ciaula, A.D. (2026). Genetic, and clinical features in Italian and lebanese subjects with familial mediterranean fever (FMF). Eur. J. Intern. Med.","DOI":"10.1016\/j.ejim.2026.106756"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Feghali, R., Ibrahim, J.N., Salem, N., Moussallem, R., Hijazi, G., Attieh, C., Yammine, T., and Chebly, A. (2025). Updates on the molecular spectrum of MEFV variants in lebanese patients with Familial Mediterranean Fever. Front. Genet., 15.","DOI":"10.3389\/fgene.2024.1506656"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ejim.2023.05.015","article-title":"Genetic and clinical features of familial mediterranean fever (FMF) in a homogeneous cohort of patients from South-Eastern Italy","volume":"115","author":"Iacoviello","year":"2023","journal-title":"Eur. J. Intern. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e106","DOI":"10.5114\/amsad.2018.77545","article-title":"Intima media thickness as an early predictor of atherosclerosis in Egyptian children with familial Mediterranean fever","volume":"3","author":"Mahmoud","year":"2018","journal-title":"Arch. Med. Sci. Atheroscler. Dis."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3769","DOI":"10.1007\/s10067-022-06326-5","article-title":"Intima media thickness of carotid arteries in familial Mediterranean fever: A systematic review and meta-analysis","volume":"41","author":"Merashli","year":"2022","journal-title":"Clin. Rheumatol."},{"key":"ref_29","first-page":"80","article-title":"Inflammation and cardiovascular disease in familial Mediterranean fever. An analysis of hospital admissions for acute cardiovascular event","volume":"36","author":"Roitman","year":"2018","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Fenner, M.F., Gatta, G., Sattler, S., Kuiper, M., Hesselkilde, E.M., Adler, D.M.T., Smerup, M., Schotten, U., S\u00f8rensen, U., and Diness, J.G. (2021). Inhibition of Small-Conductance Calcium-Activated Potassium Current (IK,Ca) Leads to Differential Atrial Electrophysiological Effects in a Horse Model of Persistent Atrial Fibrillation. Front. Physiol., 12.","DOI":"10.3389\/fphys.2021.614483"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"euaf076","DOI":"10.1093\/europace\/euaf076","article-title":"Practical compendium of antiarrhythmic drugs: A clinical consensus statement of the European Heart Rhythm Association of the European Society of Cardiology","volume":"27","author":"Merino","year":"2025","journal-title":"Europace"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/9\/1252\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T12:58:31Z","timestamp":1776862711000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/9\/1252"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,22]]},"references-count":31,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["diagnostics16091252"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics16091252","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,22]]}}}