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By delivering multifunctional cargoes with low immunogenicity, extracellular vesicles (EVs) hold the therapeutic potential to inhibit cardiomyocyte ferroptosis through the regulation of iron metabolism and the mitigation of oxidative damage. Their dual role as targeted drug carriers and natural imaging probes enhances precision in AMI management. EVs enable the non-invasive tracking of biodistribution and therapeutic responses in real time when integrated with molecular imaging technology, offering insights into cardiac repair mechanisms. This synergy between EV-based therapy and advanced imaging presents a novel strategy for AMI diagnosis and targeted intervention.<\/jats:p>","DOI":"10.3390\/diagnostics16091305","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T19:24:51Z","timestamp":1777317891000},"page":"1305","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Extracellular Vesicles in Myocardial Infarction: Dual Role in Ferroptosis Regulation and In Vivo Imaging"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1818-6539","authenticated-orcid":false,"given":"Cong","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Radiology, Shengjing Hospital of China Medical University, Shenyang 110055, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Radiology, Shengjing Hospital of China Medical University, Shenyang 110055, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"key":"ref_1","first-page":"1","article-title":"New regulators of systemic iron homeostasis","volume":"6","author":"Ganz","year":"2021","journal-title":"Signal Transduct. 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