{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:34:00Z","timestamp":1777674840899,"version":"3.51.4"},"reference-count":76,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Intestinal tuberculosis (ITB) is a complex form of extrapulmonary tuberculosis characterized by nonspecific gastrointestinal symptoms and substantial overlap with conditions such as Crohn\u2019s disease and gastrointestinal malignancies. These similarities frequently lead to diagnostic uncertainty, delayed diagnosis, and inappropriate management. This systematic review summarizes current evidence on the clinical presentation, diagnostic approaches, and therapeutic strategies for ITB, with particular emphasis on emerging diagnostic technologies and their role in reducing surgical interventions. A systematic literature search was conducted using PubMed, Scopus, and Google Scholar following PRISMA guidelines to identify relevant studies published from 2000 to 2025. The review focused on clinical manifestations, imaging findings, endoscopic features, histopathological characteristics, molecular diagnostics, pharmacological therapy, and minimally invasive therapeutic interventions. Accurate diagnosis requires an integrated approach combining clinical assessment with imaging, endoscopic evaluation, and histopathological confirmation. Molecular techniques such as GeneXpert MTB\/RIF and GeneXpert MTB\/RIF Ultra and multiplex polymerase chain reaction assays improve diagnostic accuracy and shorten detection time. Emerging technologies including artificial intelligence-assisted radiologic interpretation and CRISPR-based stool sequencing platforms show promise for earlier detection. Standard anti-tubercular therapy remains the cornerstone of treatment, while minimally invasive endoscopic and surgical procedures are effective for managing complications such as strictures, obstruction, and perforation. Early and precise diagnosis of intestinal tuberculosis is essential to prevent complications and optimize patient outcomes. Integrating conventional diagnostic approaches with emerging molecular and artificial intelligence-based technologies may enhance diagnostic precision and support individualized treatment strategies. Further ITB-specific clinical studies are needed to validate novel diagnostic tools and refine therapeutic approaches for improved patient care.<\/jats:p>","DOI":"10.3390\/diagnostics16091332","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:43:51Z","timestamp":1777448631000},"page":"1332","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Integrated Review of Conventional and Emerging Diagnostic and Therapeutic Modalities to Reduce the Risk of Surgical Resections in Intestinal Tuberculosis"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8874-1556","authenticated-orcid":false,"given":"Khalid","family":"Alyahyawi","sequence":"first","affiliation":[{"name":"Department of Surgery, College of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Zeng, J., Zhou, G., and Pan, F. (2023). Clinical analysis of intestinal tuberculosis: A retrospective study. J. Clin. Med., 12.","DOI":"10.3390\/jcm12020445"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Choudhury, A., Dhillon, J., Sekar, A., Gupta, P., Singh, H., and Sharma, V. (2023). Differentiating gastrointestinal tuberculosis and Crohn\u2019s disease: A comprehensive review. BMC Gastroenterol., 23.","DOI":"10.1186\/s12876-023-02887-0"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"261","DOI":"10.4103\/sjg.sjg_148_21","article-title":"Gastrointestinal tuberculosis: A systematic review of epidemiology, presentation, diagnosis and treatment","volume":"27","author":"Shariff","year":"2021","journal-title":"Saudi J. Gastroenterol."},{"key":"ref_4","first-page":"131","article-title":"Intestinal and peritoneal tuberculosis: Changing trends over 10 years and a review of 80 patients","volume":"48","author":"Akgun","year":"2005","journal-title":"Can. J. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Maulahela, H., Simadibrata, M., Nelwan, E.J., Rahadiani, N., Renesteen, E., Suwarti, S.W.T., and Anggraini, Y.W. (2022). Recent advances in the diagnosis of intestinal tuberculosis. BMC Gastroenterol., 22.","DOI":"10.1186\/s12876-022-02171-7"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"183","DOI":"10.5603\/ARM.2020.0102","article-title":"Role of GeneXpert in the diagnosis of Mycobacterium tuberculosis","volume":"88","author":"Sasikumar","year":"2020","journal-title":"Adv. Respir. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"81","DOI":"10.18683\/germs.2020.1188","article-title":"Utility of smear microscopy and GeneXpert for the detection of Mycobacterium tuberculosis in clinical samples","volume":"10","author":"Arora","year":"2020","journal-title":"Germs"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Di Buono, G., Buscemi, S., Lo Monte, A.I., Geraci, G., Romano, G., Maienza, E., Gulotta, L., Amato, G., and Agrusa, A. (2024). Surgical Management of Complicated Abdominal Tuberculosis: The First Systematic Review\u2014New Treatments for an Ancient Disease and the State of the Art. J. Clin. Med., 13.","DOI":"10.3390\/jcm13164894"},{"key":"ref_9","unstructured":"World Health Organization (2022). WHO Consolidated Guidelines on Tuberculosis: Module 4: Treatment, Drug-Resistant Tuberculosis Treatment, 2022 Update, World Health Organization."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Jena, A., Mohindra, R., Rana, K., Neelam, P.B., Thakur, D.C., Singh, H., Gupta, P., Suri, V., and Sharma, V. (2023). Frequency, outcomes, and need for intervention in stricturing gastrointestinal tuberculosis: A systematic review and meta-analysis. BMC Gastroenterol., 23.","DOI":"10.1186\/s12876-023-02682-x"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2050313X231184342","DOI":"10.1177\/2050313X231184342","article-title":"Intestinal Tuberculosis Can Masquerade as Crohn\u2019s Disease: A Teachable Moment","volume":"11","author":"Kc","year":"2023","journal-title":"SAGE Open Med. Case Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.2169\/internalmedicine.2361-18","article-title":"Ten Cases of Intestinal Tuberculosis Which Were Initially Misdiagnosed as Inflammatory Bowel Disease","volume":"58","author":"Sato","year":"2019","journal-title":"Intern. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"6306","DOI":"10.3748\/wjg.v23.i34.6306","article-title":"Temporal Trends in the Misdiagnosis Rates Between Crohn\u2019s Disease and Intestinal Tuberculosis","volume":"23","author":"Seo","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"ref_14","first-page":"76","article-title":"Diagnosis of Intestinal Tuberculosis at Viet Duc Hospital (2004\u20132009)","volume":"31","author":"Nguyen","year":"2010","journal-title":"Thai J. Surg."},{"key":"ref_15","first-page":"233","article-title":"Abdominal tuberculosis","volume":"33","author":"Walia","year":"1990","journal-title":"Can. J. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/apt.13840","article-title":"Endoscopic and clinical responses to anti-tubercular therapy differentiate intestinal tuberculosis from Crohn\u2019s disease","volume":"45","author":"Munot","year":"2017","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_17","first-page":"123","article-title":"The diagnosis and treatment of Crohn\u2019s disease and ulcerative colitis","volume":"106","author":"Baumgart","year":"2009","journal-title":"Dtsch. \u00c4rzteblatt Int."},{"key":"ref_18","first-page":"CD012777","article-title":"Abdominal ultrasound for diagnosing abdominal tuberculosis or disseminated tuberculosis with abdominal involvement in HIV-positive individuals","volume":"2019","author":"Griesel","year":"2019","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Aprile, F., Vangeli, M., Allocca, M., Zilli, A., Argollo, M.C., D\u2019Amico, F., Parigi, T.L., Danese, S., and Furfaro, F. (2024). Gastrointestinal ultrasound in infectious diseases. Medicina, 60.","DOI":"10.3390\/medicina60091402"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Ma, L., Zhu, Q., Li, Y., Li, W., Wang, X., Liu, W., Li, J., and Jiang, Y. (2019). The potential role of CT enterography and gastrointestinal ultrasound in the evaluation of anti-tubercular therapy response of intestinal tuberculosis: A retrospective study. BMC Gastroenterol., 19.","DOI":"10.1186\/s12876-019-1030-0"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Sinan, T., Sheikh, M., Ramadan, S., Sahwney, S., and Behbehani, A. (2002). CT features in abdominal tuberculosis: 20 years experience. BMC Med. Imaging, 2.","DOI":"10.1186\/1471-2342-2-3"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.crad.2013.10.009","article-title":"Spectrum of Imaging findings on MDCT enterography in small bowel tuberculosis","volume":"69","author":"Kalra","year":"2014","journal-title":"Clin. Radiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1159\/000496482","article-title":"Making a positive diagnosis of intestinal tuberculosis with the aid of new biologic and histologic features: How far have we reached?","volume":"3","author":"Mehta","year":"2019","journal-title":"Inflamm. Intest. Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"goac062","DOI":"10.1093\/gastro\/goac062","article-title":"Endoscopic ultrasound fine-needle biopsy versus fine-needle aspiration for lymph node tissue acquisition: A systematic review and meta-analysis","volume":"10","author":"Facciorusso","year":"2022","journal-title":"Gastroenterol. Rep."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.gie.2011.12.032","article-title":"Diagnostic yield of EUS-guided fine-needle aspiration and cytology in suspected tubercular intra-abdominal lymphadenopathy","volume":"75","author":"Puri","year":"2012","journal-title":"Gastrointest. Endosc."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Pai, M., Flores, L.L., Hubbard, A., Riley, L.W., and Colford, J.M. (2004). Nucleic acid amplification tests in the diagnosis of tuberculous pleuritis: A systematic review and meta-analysis. BMC Infect. Dis., 4.","DOI":"10.1186\/1471-2334-4-6"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Fei, B., Zhou, L., Zhang, Y., Luo, L., and Chen, Y. (2021). Application value of tissue tuberculosis antigen combined with Xpert MTB\/RIF detection in differential diagnosis of intestinal tuberculosis and Crohn\u2019s disease. BMC Infect. Dis., 21.","DOI":"10.1186\/s12879-021-06210-8"},{"key":"ref_28","first-page":"313","article-title":"Comparison of GeneXpert MTB\/RIF assay with conventional AFB smear for diagnosis of pulmonary tuberculosis in northeastern Thailand","volume":"48","author":"Reechaipichitkul","year":"2017","journal-title":"Southeast Asian J. Trop. Med. Public Health"},{"key":"ref_29","unstructured":"World Health Organization (2017). WHO Meeting Report of a Technical Expert Consultation: Non-Inferiority Analysis of Xpert MTB\/RIF Ultra Compared to Xpert MTB\/RIF, World Health Organization."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S1473-3099(17)30691-6","article-title":"Xpert MTB\/RIF Ultra for detection of Mycobacterium tuberculosis and rifampicin resistance: A prospective multicentre diagnostic accuracy study","volume":"18","author":"Dorman","year":"2018","journal-title":"Lancet Infect. Dis."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jpge.2015.07.004","article-title":"Biopsies in gastrointestinal endoscopy: When and how","volume":"23","author":"Peixoto","year":"2015","journal-title":"GE Port. J. Gastroenterol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.4103\/0366-6999.182840","article-title":"Clinical and laboratory diagnosis of intestinal tuberculosis","volume":"129","author":"Shi","year":"2016","journal-title":"Chin. Med. J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1097\/00004836-200609000-00009","article-title":"Value of adenosine deaminase in ascitic fluid for the diagnosis of tuberculous peritonitis: A meta-analysis","volume":"40","author":"Riquelme","year":"2006","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"116963","DOI":"10.1016\/j.trac.2023.116963","article-title":"Next-generation molecular diagnostics: Leveraging digital technologies to enhance multiplexing in real-time PCR","volume":"160","author":"Kreitmann","year":"2023","journal-title":"TrAC Trends Anal. Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jmoldx.2023.01.010","article-title":"CRISPR-Cas9 targeted enrichment and next-generation sequencing for mutation detection","volume":"25","author":"Malekshoar","year":"2023","journal-title":"J. Mol. Diagn."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13073-022-01054-6","article-title":"Rapid molecular diagnostics of tuberculosis resistance by targeted stool sequencing","volume":"14","author":"Sibandze","year":"2022","journal-title":"Genome Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1038\/s41598-022-05571-7","article-title":"Differentiation of intestinal tuberculosis and Crohn\u2019s disease through an explainable machine learning method","volume":"12","author":"Weng","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1111\/jgh.15433","article-title":"Deep-Learning System for Real-Time Differentiation Between Crohn\u2019s Disease, Intestinal Beh\u00e7et\u2019s Disease, and Intestinal Tuberculosis","volume":"36","author":"Kim","year":"2021","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Lu, Y., Chen, Y., Peng, X., Yao, J., Zhong, W., Li, C., and Zhi, M. (2021). Development and Validation of a New Algorithm Model for Differential Diagnosis Between Crohn\u2019s Disease and Intestinal Tuberculosis: A Combination of Laboratory, Imaging and Endoscopic Characteristics. BMC Gastroenterol., 21.","DOI":"10.1186\/s12876-021-01838-x"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1055\/s-2005-861116","article-title":"Clinical, colonoscopic, and histological profile of colonic tuberculosis in a tertiary hospital","volume":"37","author":"Alvares","year":"2005","journal-title":"Endoscopy"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.3748\/wjg.v16.i20.2496","article-title":"Histopathology and TB-PCR kit analysis in differentiating the diagnosis of intestinal tuberculosis and Crohn\u2019s disease","volume":"16","author":"Jin","year":"2010","journal-title":"World J. Gastroenterol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/ajg.2009.585","article-title":"Clinical, endoscopic, and histological differentiations between Crohn\u2019s disease and intestinal tuberculosis","volume":"105","author":"Makharia","year":"2010","journal-title":"Am. J. Gastroenterol."},{"key":"ref_43","first-page":"565","article-title":"Clinicocolonoscopic profile of colonic tuberculosis","volume":"91","author":"Singh","year":"1996","journal-title":"Am. J. Gastroenterol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1136\/gut.45.4.537","article-title":"Endoscopic mucosal biopsies are useful in distinguishing granulomatous colitis due to Crohn\u2019s disease from tuberculosis","volume":"45","author":"Pulimood","year":"1999","journal-title":"Gut"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"741","DOI":"10.3748\/wjg.14.741","article-title":"Diagnosis of Crohn\u2019s disease in India where tuberculosis is widely prevalent","volume":"14","author":"Amarapurkar","year":"2008","journal-title":"World J. Gastroenterol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1089\/sur.2017.110","article-title":"Tubercular abdominal cocoon: Systematic review of an uncommon form of tuberculosis","volume":"18","author":"Sharma","year":"2017","journal-title":"Surg. Infect."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S1473-3099(19)30649-8","article-title":"Xpert MTB\/RIF Ultra versus Xpert MTB\/RIF for the diagnosis of tuberculous meningitis: A prospective, randomised, diagnostic accuracy study","volume":"20","author":"Donovan","year":"2020","journal-title":"Lancet Infect. Dis."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"601","DOI":"10.5114\/aoms.2013.36904","article-title":"Diagnostic accuracy of adenosine deaminase for tuberculous peritonitis: A meta-analysis","volume":"9","author":"Shen","year":"2013","journal-title":"Arch. Med. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.diagmicrobio.2013.12.010","article-title":"Diagnostic value of adenosine deaminase in ascites for tuberculosis ascites: A meta-analysis","volume":"79","author":"Tao","year":"2014","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"5017","DOI":"10.3748\/wjg.v20.i17.5017","article-title":"Routine diagnosis of intestinal tuberculosis and Crohn\u2019s disease in Southern India","volume":"20","author":"Larsson","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/ajg.2016.529","article-title":"Meta-analytic Bayesian model for differentiating intestinal tuberculosis from Crohn\u2019s disease","volume":"112","author":"Limsrivilai","year":"2017","journal-title":"Am. J. Gastroenterol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1463-1318.2009.02131.x","article-title":"Inflammatory bowel disease: A systematic review on the value of diagnostic testing in primary care","volume":"13","author":"Jellema","year":"2011","journal-title":"Color. Dis."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1007\/s10620-017-4727-3","article-title":"Tubercular intestinal strictures show poor response to anti-tuberculous therapy","volume":"62","author":"Aggarwal","year":"2017","journal-title":"Dig. Dis. Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"456","DOI":"10.47310\/jpms202514S0160","article-title":"Clinical study of intestinal tuberculosis and its response to short-course anti-tuberculosis therapy","volume":"14","author":"Aljarallah","year":"2025","journal-title":"J. Pioneer. Med. Sci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"4167","DOI":"10.1128\/AAC.00874-09","article-title":"Prospective randomized trial of six-month versus nine-month therapy for intestinal tuberculosis","volume":"53","author":"Park","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1093\/cid\/ciz1107","article-title":"Clinical Outcomes Among Patients with Drug-resistant Tuberculosis Receiving Bedaquiline- or Delamanid-Containing Regimens","volume":"71","author":"Kempker","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"ref_57","unstructured":"World Health Organization (2020). WHO Consolidated Guidelines on Tuberculosis: Module 4: Treatment, Drug-Resistant Tuberculosis Treatment, World Health Organization."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1056\/NEJMoa1901814","article-title":"Treatment of highly drug-resistant pulmonary tuberculosis","volume":"382","author":"Conradie","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.1038\/s41598-017-03514-1","article-title":"Efficacy and safety of Mycobacterium indicus pranii as an adjunct therapy in Category II pulmonary tuberculosis: A randomized trial","volume":"7","author":"Sharma","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Gupta, A., Ahmad, F.J., Ahmad, F., Gupta, U.D., Natarajan, M., Katoch, V., and Bhaskar, S. (2012). Immunotherapy with Mycobacterium indicus pranii as an adjunct to chemotherapy for tuberculosis. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0039215"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Mi, J., Wu, X., and Liang, J. (2024). Advances in adjuvant therapy for tuberculosis with immunoregulatory compounds. Front. Microbiol., 15.","DOI":"10.3389\/fmicb.2024.1380848"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s15010-018-1235-0","article-title":"Use of steroids for abdominal tuberculosis: A systematic review and meta-analysis","volume":"47","author":"Soni","year":"2019","journal-title":"Infection"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.3393\/ac.2020.03.16.1","article-title":"Intestinal Perforation as a Paradoxical Reaction to Antitubercular Therapy: A Case Report","volume":"37","author":"Kang","year":"2021","journal-title":"Ann. Coloproctology"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1136\/thx.2003.019224","article-title":"Paradoxical reactions during tuberculosis treatment in patients with and without HIV coinfection","volume":"59","author":"Breen","year":"2004","journal-title":"Thorax"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1097\/MEG.0000000000001879","article-title":"Serial measurements of faecal calprotectin may discriminate intestinal tuberculosis and Crohn\u2019s disease in patients started on antitubercular therapy","volume":"33","author":"Sharma","year":"2021","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Kumar, P., Jena, A., Birda, C.L., Mandavdhare, H.S., Singh, H., Gupta, P., Prasad, K.K., and Sharma, V. (2022). Safety and efficacy of non-fluoroscopic endoscopic dilatation of gastrointestinal tuberculosis related strictures. BMC Gastroenterol., 22.","DOI":"10.1186\/s12876-022-02140-0"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"otaa069","DOI":"10.1093\/crocol\/otaa069","article-title":"Endoscopic stricturotomy for management of strictures in inflammatory bowel disease","volume":"2","author":"Kochhar","year":"2020","journal-title":"Crohns Colitis 360"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"4152","DOI":"10.1007\/s10620-024-08533-3","article-title":"Efficacy and safety of endoscopic stricturotomy in inflammatory bowel disease-related strictures: A systematic review and meta-analysis","volume":"69","author":"Jaber","year":"2024","journal-title":"Dig. Dis. Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"3432","DOI":"10.1007\/s00464-015-4114-0","article-title":"Laparoscopic adhesiolysis for acute small bowel obstruction: Systematic review and pooled analysis","volume":"29","author":"Wiggins","year":"2015","journal-title":"Surg. Endosc."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1007\/s00464-002-4537-2","article-title":"Laparoscopic drainage of a peripancreatic tuberculous abscess","volume":"17","author":"Bhandarkar","year":"2003","journal-title":"Surg. Endosc."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1159\/000518419","article-title":"Fecal Lactoferrin and Other Putative Fecal Biomarkers in Crohn\u2019s Disease: Do They Still Have a Potential Clinical Role?","volume":"102","author":"Vernia","year":"2021","journal-title":"Digestion"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1177\/2050640614546947","article-title":"Faecal calprotectin levels differentiate intestinal from pulmonary tuberculosis: An observational study from Southern India","volume":"2","author":"Larsson","year":"2014","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"256","DOI":"10.5946\/ce.2021.061","article-title":"Value of fecal calprotectin measurement during the initial period of therapeutic anti-tubercular trial","volume":"55","author":"Jo","year":"2022","journal-title":"Clin. Endosc."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1128\/CMR.00034-13","article-title":"Gamma interferon release assays for detection of Mycobacterium tuberculosis infection","volume":"27","author":"Pai","year":"2014","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4292\/wjgpt.v7.i1.41","article-title":"Emerging role of novel biomarkers in the diagnosis of inflammatory bowel disease","volume":"7","author":"Poullis","year":"2016","journal-title":"World J. Gastrointest. Pharmacol. Ther."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1097\/RTI.0000000000000499","article-title":"Artificial intelligence in diagnostic imaging: Status quo, challenges, and future opportunities","volume":"35","author":"Sharma","year":"2020","journal-title":"J. Thorac. 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