{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:32:53Z","timestamp":1792513973363,"version":"4.5.0"},"reference-count":35,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: Liver cirrhosis, particularly in its decompensated stages, is associated with high short-term mortality among hospitalized patients. Although the prognostic value of the Child\u2013Pugh classification is well established, its independent impact on survival in real-world tertiary emergency settings requires further evaluation. This study aimed to assess the prognostic role of Child\u2013Pugh stage and other clinical factors on short- and mid-term survival in hospitalized cirrhotic patients over a 10-year period. Methods: We conducted a retrospective cohort study including 2831 patients hospitalized for liver cirrhosis between 2015 and 2025. Among them, 631 patients with complete Child\u2013Pugh staging were included in the survival analysis. Survival time was defined as the interval between the first hospitalization and the last recorded discharge or in-hospital death. Survival differences were assessed using Kaplan\u2013Meier curves and log-rank tests, while independent predictors of mortality were identified using multivariate Cox proportional hazards regression. A complementary logistic regression model was used to evaluate predictors of mortality as a binary outcome. Results: Among the 631 staged patients, 13.5% were classified as Child\u2013Pugh A, 31.9% as Child\u2013Pugh B and 54.7% as Child\u2013Pugh C. In-hospital mortality increased significantly across stages (1.2%, 9.0% and 46.7%, respectively; p &lt; 0.001). One-year survival was 98.7% for Child\u2013Pugh A, 83.6% for Child\u2013Pugh B and 40.7% for Child\u2013Pugh C (log-rank p &lt; 0.001). In multivariate Coxregression analysis, the strongest predictor of mortality was mixed cirrhosis type (HR = 8.58, 95% CI: 4.81\u201315.32, p &lt; 0.001). Child\u2013Pugh C was also independently associated with a markedly increased mortality risk compared with Child\u2013Pugh A (HR = 25.11, 95% CI: 3.44\u2013183.29, p = 0.002). Alcohol-related etiology (HR = 1.81, 95% CI: 1.09\u20133.01, p = 0.023) and age (HR = 1.18 per SD increase, 95% CI: 1.00\u20131.39, p = 0.050) were additionalindependent predictors. The Cox model demonstrated good discrimination (C-statistic \u2248 0.80). In the logistic regression model, mixed cirrhosis type (OR = 13.28, p &lt; 0.001) and Child\u2013Pugh stage (OR = 8.66, p &lt; 0.001) were the strongest predictors of mortality, while ascites showed an inverse association after adjustment (OR = 0.62, p = 0.036). The logistic model showed excellent discrimination (AUC = 0.865). Conclusions: Child\u2013Pugh stage remains a strong and independent predictor of survival in hospitalized patients with decompensated cirrhosis. The marked survival gradient across stages, particularly the substantially reduced survival observed in Child\u2013Pugh C patients, highlights thecontinued clinical utility of this simple classification for early risk stratification intertiary emergency hospital settings.<\/jats:p>","DOI":"10.3390\/diagnostics16091349","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:01:18Z","timestamp":1777474878000},"page":"1349","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Child\u2013Pugh Stage Predicts Survival in Hospitalized Patients with Decompensated Cirrhosis: A 10-Year Cohort Study"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6704-4890","authenticated-orcid":false,"given":"Ion","family":"Dina","sequence":"first","affiliation":[{"name":"Clinical Department 1\u2014Medical Semiology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Gastroenterology Department, Clinical and Emergency Hospital \u201cSf. Ioan\u201d, 042122 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia Georgeta","family":"Iacobescu","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Clinical and Emergency Hospital \u201cSf. Ioan\u201d, 042122 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioana Valeria","family":"Grigorescu","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Clinical and Emergency Hospital \u201cSf. Ioan\u201d, 042122 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ion Daniel","family":"Baboi","sequence":"additional","affiliation":[{"name":"Clinical Department 1\u2014Medical Semiology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Gastroenterology Department, Clinical and Emergency Hospital \u201cSf. Ioan\u201d, 042122 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian-Vlad","family":"Lapadat","sequence":"additional","affiliation":[{"name":"Clinical Department 1\u2014Medical Semiology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Gastroenterology Department, Clinical and Emergency Hospital \u201cSf. Ioan\u201d, 042122 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0441-3905","authenticated-orcid":false,"given":"Lavinia Alice","family":"B\u0103l\u0103ceanu","sequence":"additional","affiliation":[{"name":"Clinical Department 1\u2014Medical Semiology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Internal Medicine Department, Clinical and Emergency Hospital \u201cSf. Ioan\u201d, 042122 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.jhep.2023.03.017","article-title":"Global burden of liver disease: 2023 update","volume":"79","author":"Devarbhavi","year":"2023","journal-title":"J. Hepatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e70001","DOI":"10.1111\/liv.70001","article-title":"The global burden of cirrhosis and other chronic liver diseases in 2021","volume":"45","author":"Tham","year":"2025","journal-title":"Liver Int."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Ao, Z., Chen, X., Zhu, W., Li, H., Wang, J., and Liu, Y. (2025). The prognostic nutritional index is an effective prognostic and nutritional status indicator for cirrhosis. 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