{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T05:09:40Z","timestamp":1778389780940,"version":"3.51.4"},"reference-count":29,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: Portal vein thrombosis (PVT) is a clinically significant condition in which early risk stratification remains challenging, particularly in emergency settings where rapid decision-making is required. This study aimed to evaluate the prognostic value of the Systemic Immune-Inflammation Index (SII), Systemic Inflammation Response Index (SIRI), and the Model for End-Stage Liver Disease (MELD) score in predicting the need for intensive care in patients with PVT. Methods: A retrospective analysis was conducted on adult patients (&gt;18 years) diagnosed with PVT in the emergency department between January 2018 and December 2024. A total of 29 patients meeting the inclusion and exclusion criteria were included. Demographic characteristics, laboratory parameters, Intensive Care Unit (ICU) admission status, and 90-day mortality were analyzed. The sensitivity and specificity of MELD, SII, and SIRI for predicting ICU admission were calculated. Non-normally distributed variables were expressed as median (interquartile range, IQR) and compared using the Mann\u2013Whitney U test. Results: The mean age of patients was 60.5 \u00b1 16.2 years, and 18\/29 (62.1%) were male. ICU admission was required in 9\/29 (31.0%) of cases. MELD score (median 18.7 [11.0\u201321.9] vs. 7.9 [6.7\u201313.5], p = 0.003), bilirubin (median 2.4 [1.0\u20134.2] vs. 0.7 [0.4\u20131.1], p = 0.016), and SIRI (median 6.4 [2.3\u201321.3] vs. 1.4 [0.6\u20139.3], p = 0.038) were significantly higher in ICU-admitted patients. MELD score showed 66.7% sensitivity and 95% specificity, while SIRI had 88.9% sensitivity and 55% specificity for ICU prediction. Conclusions: MELD score, bilirubin, and SIRI are significantly associated with ICU admission in PVT patients. Their integration into emergency department protocols may assist in early risk stratification and resource allocation.<\/jats:p>","DOI":"10.3390\/diagnostics16091368","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T06:50:01Z","timestamp":1777618201000},"page":"1368","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Effectiveness of Systemic Immune-Inflammation Index (SII) and Systemic Inflammation Response Index (SIRI) and Model for End-Stage Liver Disease (MELD) Score in Predicting Prognosis in Portal Vein Thrombosis, a Pilot Study"],"prefix":"10.3390","volume":"16","author":[{"given":"Sevgi","family":"Yumrutepe","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Malatya Training and Research Hospital, 44000 Malatya, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4092-1192","authenticated-orcid":false,"given":"Turgut","family":"Dolanbay","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Faculty of Medicine, Malatya Turgut \u00d6zal University, 44210 Malatya, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1184-9467","authenticated-orcid":false,"given":"S\u00fcleyman","family":"Nogay","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Faculty of Medicine, Malatya Turgut \u00d6zal University, 44210 Malatya, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3458-2398","authenticated-orcid":false,"given":"Bilgehan","family":"Demir","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Faculty of Medicine, Malatya Turgut \u00d6zal University, 44210 Malatya, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8799-4065","authenticated-orcid":false,"given":"Muhammed Eyy\u00fcb","family":"Polat","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Faculty of Medicine, Malatya Turgut \u00d6zal University, 44210 Malatya, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jceh.2014.12.008","article-title":"Portal vein thrombosis","volume":"5","author":"Chawla","year":"2015","journal-title":"J. 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