{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:22:24Z","timestamp":1785435744744,"version":"3.56.0"},"reference-count":93,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Carol Davila University of Medicine and Pharmacy, Bucharest, Romania"},{"id":[{"id":"https:\/\/ror.org\/04fm87419","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background and Clinical Significance: Eosinophilic esophagitis (EoE) is a chronic, immune-mediated inflammatory disorder characterized by esophageal dysfunction and dense eosinophilic infiltration. EoE frequently evolves into a fibrostenotic phenotype, in which uncontrolled inflammation drives progressive tissue remodeling. This evolution increases the risk of complex structural complications\u2014most commonly fixed rings and strictures, and, in rare advanced cases, deep mural injury or fistulization\u2014substantially increasing both diagnostic and therapeutic complexity. Case Presentation: This report describes an uncommon presentation of EoE complicated by a blind-ending esophageal fistula, managed successfully through a multidisciplinary strategy integrating pharmacologic therapy, dietary modification, and endoscopic intervention. Conclusions: Nutritional support through gastrostomy, combined with multidisciplinary medical and endoscopic management, can lead to favorable outcomes in EoE complicated by esophageal fistula. Early recognition and individualized management are essential to optimize outcomes.<\/jats:p>","DOI":"10.3390\/diagnostics16091374","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T06:50:01Z","timestamp":1777618201000},"page":"1374","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Blind-Ending Esophageal Fistula Complicating Eosinophilic Esophagitis: Case Report and Up-to-Date Strategy from Diagnosis to Therapy"],"prefix":"10.3390","volume":"16","author":[{"given":"Anthony","family":"Rasuceanu","sequence":"first","affiliation":[{"name":"Doctoral School, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of Esophageal and General Surgery, Sf. Maria Clinical Hospital, 011192 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Constantin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of Esophageal and General Surgery, Sf. Maria Clinical Hospital, 011192 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0095-494X","authenticated-orcid":false,"given":"Florin","family":"Achim","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of Esophageal and General Surgery, Sf. Maria Clinical Hospital, 011192 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex-Claudiu","family":"Moraru","sequence":"additional","affiliation":[{"name":"Doctoral School, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of Esophageal and General Surgery, Sf. Maria Clinical Hospital, 011192 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandru","family":"Rotariu","sequence":"additional","affiliation":[{"name":"Doctoral School, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of Esophageal and General Surgery, Sf. Maria Clinical Hospital, 011192 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreea-Gabriela","family":"Manole","sequence":"additional","affiliation":[{"name":"Department of Esophageal and General Surgery, Sf. Maria Clinical Hospital, 011192 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petre","family":"Hoara","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of Esophageal and General Surgery, Sf. Maria Clinical Hospital, 011192 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana-Elena","family":"Stefan","sequence":"additional","affiliation":[{"name":"Doctoral School, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of Esophageal and General Surgery, Sf. Maria Clinical Hospital, 011192 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madalina-Georgiana","family":"Mitrea-Tocitu","sequence":"additional","affiliation":[{"name":"Doctoral School, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of Esophageal and General Surgery, Sf. Maria Clinical Hospital, 011192 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Rosianu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Sf. Maria Clinical Hospital, 011192 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca","family":"Evsei-Seceleanu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of Pathology, Sf. Maria Clinical Hospital, 011192 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9945-6328","authenticated-orcid":false,"given":"Dragos-Viorel","family":"Scripcariu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania"},{"name":"First Oncological Surgery Unit, Regional Institute of Oncology, 700483 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4495-0828","authenticated-orcid":false,"given":"Dragos","family":"Predescu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of Esophageal and General Surgery, Sf. Maria Clinical Hospital, 011192 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"238","DOI":"10.3390\/gastroent13030024","article-title":"First therapeutic approval for eosinophilic esophagitis","volume":"13","author":"Chiles","year":"2022","journal-title":"Gastroenterol. Insights"},{"key":"ref_2","first-page":"729","article-title":"Eosinophilic oesophagitis: A guide for primary care","volume":"44","author":"Yaxley","year":"2015","journal-title":"Aust. Fam. Physician"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"W\u0105sik, J., and Ma\u0142ecka-Wojciesko, E. (2023). Eosinophilic esophagitis-what do we know so far?. J. Clin. Med., 12.","DOI":"10.3390\/jcm12062259"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1159\/000543022","article-title":"Epidemiology of eosinophilic esophagitis: Really a novel and evolving disease?","volume":"10","author":"Mona","year":"2025","journal-title":"Inflamm. Intest. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.bpg.2015.09.005","article-title":"Clinical features of eosinophilic esophagitis in children and adults","volume":"29","author":"Miehlke","year":"2015","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"486","DOI":"10.7861\/clinmedicine.12-5-486","article-title":"Young man presenting with recurrent food bolus impaction","volume":"12","author":"Williams","year":"2012","journal-title":"Clin. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1542\/pir.2017-0266","article-title":"Pediatric esophageal disorders: Diagnosis and treatment of reflux and eosinophilic esophagitis","volume":"39","author":"Adamiak","year":"2018","journal-title":"Pediatr. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Musburger, B.G., Gonzalez Echeandia, M., Suskind, E.L., Suskind, D.L., Zheng, H.B., and Mark, D. (2025). Current and emerging therapies for eosinophilic esophagitis (EoE): A comprehensive review. Pharmaceutics, 17.","DOI":"10.3390\/pharmaceutics17060753"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1016\/j.jaip.2023.06.035","article-title":"Recent advances in the treatment of eosinophilic esophagitis","volume":"11","author":"Uchida","year":"2023","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.gtc.2021.08.001","article-title":"Eosinophilic esophagitis: Incidence, diagnosis, management, and future directions","volume":"50","year":"2021","journal-title":"Gastroenterol. Clin. North Am."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/ajg.2008.40","article-title":"Pathology of eosinophilic esophagitis: What the clinician needs to know","volume":"104","author":"Odze","year":"2009","journal-title":"Am. J. Gastroenterol."},{"key":"ref_12","first-page":"1","article-title":"Newly developed and validated eosinophilic esophagitis histology scoring system and evidence that it outperforms peak eosinophil count for disease diagnosis and monitoring","volume":"30","author":"Collins","year":"2017","journal-title":"Dis. Esophagus"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Collins, M.H., Capocelli, K., and Yang, G.Y. (2018). Eosinophilic gastrointestinal disorders pathology. Front. Med., 4.","DOI":"10.3389\/fmed.2017.00261"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"396","DOI":"10.5858\/arpa.2024-0392-ED","article-title":"The pathologic diagnosis of eosinophilic esophagitis: Time for reassessment","volume":"149","author":"Younes","year":"2025","journal-title":"Arch. Pathol. Lab. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/s41395-018-0052-5","article-title":"The natural course of eosinophilic esophagitis and long-term consequences of undiagnosed disease in a large cohort","volume":"113","author":"Warners","year":"2018","journal-title":"Am. J. Gastroenterol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1038\/ajg.2009.657","article-title":"Esophageal dilation in eosinophilic esophagitis: Effectiveness, safety, and impact on the underlying inflammation","volume":"105","author":"Schoepfer","year":"2010","journal-title":"Am. J. Gastroenterol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.giec.2007.09.014","article-title":"Histopathologic features of eosinophilic esophagitis","volume":"18","author":"Collins","year":"2008","journal-title":"Gastrointest. Endosc. Clin. N. Am."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"100816","DOI":"10.1016\/j.gastha.2025.100816","article-title":"Differences in clinical presentation and treatment response of patients with eosinophilic esophagitis complicated by esophageal food impaction","volume":"5","author":"Redd","year":"2025","journal-title":"Gastro Hep Adv."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.gtc.2014.02.015","article-title":"Clinical implications and pathogenesis of esophageal remodeling in eosinophilic esopha-gitis","volume":"43","author":"Hirano","year":"2014","journal-title":"Gastroenterol. Clin. N. Am."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/00313020701716482","article-title":"Clinical and pathological features of eosinophilic oesophagitis: A review","volume":"40","author":"Chang","year":"2008","journal-title":"Pathology"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Michelon, M., Savarino, E.V., Montori, M., Argenziano, M.E., Poortmans, P.J., Visaggi, P., Penagini, R., Tate, D.J., Coletta, M., and Sorge, A. (2025). Endoscopic dilation for fibrostenotic complications in eosinophilic esophagitis: A narrative review. Allergies, 5.","DOI":"10.3390\/allergies5020017"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Arias-Gonz\u00e1lez, L., Rodr\u00edguez-Alcolado, L., Laserna-Mendieta, E.J., Navarro, P., Lucendo, A.J., and Grueso-Navarro, E. (2024). Fibrous remodeling in eosinophilic esophagitis: Clinical facts and pathophysiological uncertainties. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25020927"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1159\/000477391","article-title":"Progression from an inflammatory to a fibrostenotic phenotype in eosinophilic esoph-agitis","volume":"11","author":"Koutlas","year":"2017","journal-title":"Case Rep. Gastroenterol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/nyas.14501","article-title":"Pathophysiology and treatment options for gastroesophageal reflux disease: Looking beyond acid","volume":"1486","author":"Sharma","year":"2021","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"4598","DOI":"10.3748\/wjg.v25.i32.4598","article-title":"Eosinophilic esophagitis: Current concepts in diagnosis and treatment","volume":"25","author":"Delgado","year":"2019","journal-title":"World J. Gastroenterol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.cgh.2018.05.045","article-title":"Maintenance treatment of eosinophilic esophagitis with swallowed topical steroids alters disease course over a 5-year follow-up period in adult patients","volume":"17","author":"Greuter","year":"2019","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jaci.2015.05.045","article-title":"Long-term assessment of esophageal remodeling in patients with pediatric eosinophilic esophagitis treated with topical corticosteroids","volume":"137","author":"Rajan","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.cgh.2015.07.041","article-title":"Efficacy of proton pump inhibitor drugs for inducing clinical and histologic remission in patients with symptomatic esophageal eosinophilia: A systematic review and meta-analysis","volume":"14","author":"Lucendo","year":"2016","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1007\/s10620-025-08874-7","article-title":"An esophageal luminal diameter of 16 mm predicts dysphagia resolution in eosinophilic esophagitis","volume":"70","author":"Beveridge","year":"2025","journal-title":"Dig. Dis. Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"5395","DOI":"10.3748\/wjg.v26.i36.5395","article-title":"Treatment of eosinophilic esophagitis with swallowed topical corticosteroids","volume":"26","author":"Nennstiel","year":"2020","journal-title":"World J. Gastroenterol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1053\/j.gastro.2020.02.038","article-title":"AGA Institute and the Joint Task Force on Allergy-Immunology Practice Parameters clinical guidelines for the management of eosinophilic esophagitis","volume":"158","author":"Hirano","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/MPG.0b013e3182a80be1","article-title":"Management guidelines of eosinophilic esophagitis in childhood","volume":"58","author":"Papadopoulou","year":"2014","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Zhang, X., Cheng, E., Huo, X., Yu, C., Zhang, Q., Pham, T.H., Wang, D.H., Spechler, S.J., and Souza, R.F. (2012). Omeprazole blocks STAT6 binding to the eotaxin-3 promoter in eosinophilic esophagitis cells. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0050037"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1097\/MOG.0000000000000842","article-title":"Refractory eosinophilic esophagitis: What to do when the patient has not responded to proton pump inhibitors, steroids and diet","volume":"38","author":"Strauss","year":"2022","journal-title":"Curr. Opin. Gastroenterol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1080\/1750743X.2024.2377060","article-title":"The role of dupilumab in the treatment of eosinophilic esophagitis","volume":"16","author":"Syverson","year":"2024","journal-title":"Immunotherapy"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1056\/NEJMoa2205982","article-title":"Dupilumab in adults and adolescents with eosinophilic esophagitis","volume":"387","author":"Dellon","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1056\/NEJMoa2312282","article-title":"Dupilumab for eosinophilic esophagitis in patients 1 to 11 years of age","volume":"390","author":"Chehade","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jaci.2019.10.027","article-title":"Emerging therapies for eosinophilic esophagitis","volume":"145","author":"Greuter","year":"2020","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.bpg.2015.09.012","article-title":"Allergic mechanisms of eosinophilic oesophagitis","volume":"29","author":"Leung","year":"2015","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1136\/gut.2009.178558","article-title":"Anti-interleukin-5 antibody treatment (mepolizumab) in active eosinophilic oesophagitis: A randomized, placebo-controlled, double-blind trial","volume":"59","author":"Straumann","year":"2010","journal-title":"Gut"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.jaci.2011.11.044","article-title":"Reslizumab in children and adolescents with eosinophilic esophagitis: Results of a double-blind, randomized, placebo-controlled trial","volume":"129","author":"Spergel","year":"2012","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e126219","DOI":"10.1172\/jci.insight.126219","article-title":"Siglec-8 antibody reduces eosinophils and mast cells in a transgenic mouse model of eosinophilic gastroenteritis","volume":"4","author":"Youngblood","year":"2019","journal-title":"JCI Insight"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1056\/NEJMoa2012047","article-title":"Anti-Siglec-8 antibody for eosinophilic gastritis and duodenitis","volume":"383","author":"Dellon","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.anai.2022.06.015","article-title":"Biologics in eosinophilic gastrointestinal diseases","volume":"130","author":"Dellon","year":"2023","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1080\/1744666X.2025.2565663","article-title":"Personalization of therapy for patients with eosinophilic esophagitis","volume":"21","author":"Ottoni","year":"2025","journal-title":"Expert Rev. Clin. Immunol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.anai.2025.05.016","article-title":"Future of therapy and monitoring for eosinophilic esophagitis and eosinophilic gastrointestinal diseases","volume":"135","author":"Dickerson","year":"2025","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Kalra, S., Chowdhary, R., Kalra, E., Dhall, S., Sohi, G.S., Singh, A., Vuthaluru, A.R., and Goyal, M.K. (2025). JAK-STAT inhibitors: A game changer, from rheumatology to gastroenterology. Med. Res. Arch., 13.","DOI":"10.18103\/mra.v13i9.6935"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s11882-026-01253-w","article-title":"Eosinophilic esophagitis: Mechanisms of disease and approach to treatment","volume":"26","author":"Gautam","year":"2026","journal-title":"Curr. Allergy Asthma Rep."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Herrera-deGuise, C., Serra-Ruiz, X., Lastiri, E., and Borruel, N. (2023). JAK inhibitors: A new dawn for oral therapies in inflammatory bowel diseases. Front. Med., 10.","DOI":"10.3389\/fmed.2023.1089099"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Pasta, A., Calabrese, F., Furnari, M., Savarino, E.V., Visaggi, P., Bodini, G., Formisano, E., Zentilin, P., Giannini, E.G., and Marabotto, E. (2025). Endoscopic management of eosinophilic esophagitis: A narrative review on diagnosis and treatment. J. Clin. Med., 14.","DOI":"10.3390\/jcm14113756"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Farah, A., Assaf, T., Hindy, J., Abboud, W., Mahamid, M., Savarino, E.V., and Mari, A. (2025). The dynamic evolution of eosinophilic esophagitis. Diagnostics, 15.","DOI":"10.3390\/diagnostics15030240"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1053\/j.gastro.2014.02.006","article-title":"Efficacy of dietary interventions for inducing histologic remission in patients with eosinophilic esophagitis: A systematic review and meta-analysis","volume":"146","author":"Arias","year":"2014","journal-title":"Gastroenterology"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s11894-016-0531-z","article-title":"Eosinophilic esophagitis from an allergy perspective: How to optimally pursue allergy testing and dietary modification in the adult population","volume":"18","author":"McGowan","year":"2016","journal-title":"Curr. Gastroenterol. Rep."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.jaci.2012.12.664","article-title":"Empiric 6-food elimination diet induced and maintained prolonged remission in patients with adult eosinophilic esophagitis: A prospective study on the food cause of the disease","volume":"131","author":"Lucendo","year":"2013","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.cgh.2006.05.026","article-title":"Effect of six-food elimination diet on clinical and histologic outcomes in eosinophilic esophagitis","volume":"4","author":"Kagalwalla","year":"2006","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1053\/j.gastro.2012.03.001","article-title":"Elimination diet effectively treats eosinophilic esophagitis in adults; food reintroduction identifies causative factors","volume":"142","author":"Gonsalves","year":"2012","journal-title":"Gastroenterology"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jaci.2018.02.028","article-title":"Dietary therapy for eosinophilic esophagitis","volume":"142","author":"Lucendo","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/j.jaci.2017.08.038","article-title":"Step-up empiric elimination diet for pediatric and adult eosinophilic esophagitis: The 2-4-6 study","volume":"141","author":"Arias","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1111\/all.12420","article-title":"Efficacy of IgE-targeted vs empiric six-food elimination diets for adult eosinophilic oesophagitis","volume":"69","author":"Brito","year":"2014","journal-title":"Allergy"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1016\/j.cgh.2023.03.006","article-title":"Development of a practical guide to implement and monitor diet therapy for eosinophilic esophagitis","volume":"21","author":"Chang","year":"2023","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.anai.2025.03.019","article-title":"Insights into the natural history and disease course of eosinophilic esophagitis","volume":"135","author":"Ketchum","year":"2025","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_62","first-page":"243","article-title":"Dilation-predominant approach versus routine care in patients with difficult-to-treat eosinophilic esophagitis: A retrospective comparison","volume":"54","author":"Greenberg","year":"2021","journal-title":"Endoscopy"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1053\/j.gastro.2013.08.015","article-title":"Delay in diagnosis of eosinophilic esophagitis increases risk for stricture formation in a time-dependent manner","volume":"145","author":"Schoepfer","year":"2013","journal-title":"Gastroenterology"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1007\/s11938-023-00428-y","article-title":"Endoscopic diagnosis and response evaluation in patients with eosinophilic esophagitis","volume":"21","author":"Sorge","year":"2023","journal-title":"Curr. Treat. Options Gastroenterol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.gastha.2024.01.010","article-title":"Course of esophageal strictures in eosinophilic esophagitis using structured esophagram protocol","volume":"3","author":"Snyder","year":"2024","journal-title":"Gastro Hep Adv."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.cgh.2013.03.020","article-title":"Esophageal distensibility as a measure of disease severity in patients with eosinophilic esophagitis","volume":"11","author":"Hirano","year":"2013","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"e119","DOI":"10.1038\/ctg.2017.47","article-title":"Improvement in esophageal distensibility in response to medical and diet therapy in eosinophilic esophagitis","volume":"8","author":"Carlson","year":"2017","journal-title":"Clin. Transl. Gastroenterol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.anai.2018.05.006","article-title":"Medical and dietary management of eosinophilic esophagitis","volume":"121","author":"Nhu","year":"2018","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1155\/2006\/521583","article-title":"How do I dilate a benign esophageal stricture?","volume":"20","author":"Khanna","year":"2006","journal-title":"Can. J. Gastroenterol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1097\/MOG.0000000000000442","article-title":"Esophageal dilation in eosinophilic esophagitis: Risks, benefits, and when to do it","volume":"34","author":"Lucendo","year":"2018","journal-title":"Curr. Opin. Gastroenterol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"105963","DOI":"10.4240\/wjgs.v17.i6.105963","article-title":"Endoscopic treatment of benign esophageal strictures: Advances and challenges","volume":"17","author":"Chen","year":"2025","journal-title":"World J. Gastrointest. Surg."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/dote\/dox042","article-title":"Control of inflammation decreases the need for subsequent esophageal dilation in patients with eosinophilic esophagitis","volume":"30","author":"Runge","year":"2017","journal-title":"Dis. Esophagus"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/ajg.2015.399","article-title":"Outcomes of esophageal dilation in eosinophilic esophagitis: Safety, efficacy, and persistence of the fibrostenotic phenotype","volume":"111","author":"Runge","year":"2016","journal-title":"Am. J. Gastroenterol."},{"key":"ref_74","first-page":"320","article-title":"Esophageal dilation as the primary treatment for eosinophilic esophagitis","volume":"15","author":"Katzka","year":"2019","journal-title":"Gastroenterol. Hepatol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1053\/j.gastro.2017.05.066","article-title":"Diagnosis and treatment of eosinophilic esophagitis","volume":"154","author":"Straumann","year":"2018","journal-title":"Gastroenterology"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.gie.2022.05.013","article-title":"Endoscopic approach to eosino-philic esophagitis: American Society for Gastrointestinal Endoscopy consensus conference","volume":"96","author":"Aceves","year":"2022","journal-title":"Gastrointest. Endosc."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.gie.2017.04.028","article-title":"Esophageal dilation with either bougie or balloon technique as a treatment for eosinophilic esophagitis: A systematic review and meta-analysis","volume":"86","author":"Dougherty","year":"2017","journal-title":"Gastrointest. Endosc."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.gie.2017.05.019","article-title":"Esophageal dilation for eosinophilic esophagitis: It\u2019s safe! Why aren\u2019t we doing more dilations?","volume":"86","author":"Richter","year":"2017","journal-title":"Gastrointest. Endosc."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1007\/s10620-010-1165-x","article-title":"A systematic review of the risk of perforation during esophageal dilation for patients with eosinophilic esophagitis","volume":"55","author":"Jacobs","year":"2010","journal-title":"Dig. Dis. Sci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1001\/jama.2021.14920","article-title":"Eosinophilic esophagitis: A review","volume":"326","author":"Muir","year":"2021","journal-title":"JAMA"},{"key":"ref_81","first-page":"385","article-title":"Perforation during esophageal dilatation: A 10-year experience","volume":"22","author":"Hagel","year":"2013","journal-title":"J. Gastrointest. Liver Dis."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1053\/j.gastro.2023.10.035","article-title":"Concepts and controversies in eosinophilic esophagitis: What\u2019s coming down the pipe?","volume":"166","author":"Peterson","year":"2024","journal-title":"Gastroenterology"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1053\/j.gastro.2020.07.039","article-title":"Budesonide orodispersible tablets maintain remission in a randomized, placebo-controlled trial of patients with eosinophilic esophagitis","volume":"159","author":"Straumann","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1696849","DOI":"10.1155\/2018\/1696849","article-title":"Progress on the prevention of esophageal stricture after endoscopic submucosal dissection","volume":"2018","author":"Shi","year":"2018","journal-title":"Gastroenterol. Res. Pract."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.tgie.2013.08.009","article-title":"Esophageal dilation in eosinophilic esophagitis","volume":"16","author":"Alexander","year":"2014","journal-title":"Tech. Gastrointest. Endosc."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/apt.14123","article-title":"Systematic review with meta-analysis: Endoscopic dilation is highly effective and safe in children and adults with eosinophilic oesophagitis","volume":"46","author":"Moawad","year":"2017","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1146\/annurev-pathol-012615-044241","article-title":"Mechanisms of disease of eosinophilic esophagitis","volume":"11","author":"Davis","year":"2016","journal-title":"Annu. Rev. Pathol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"A76","DOI":"10.1016\/j.chest.2020.08.103","article-title":"Complications of eosinophilic esophagitis","volume":"158","author":"Nasim","year":"2020","journal-title":"Chest"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.dld.2019.10.019","article-title":"Esophageal perforation in eosinophilic esophagitis: A systematic review on clinical presentation, management and outcomes","volume":"52","author":"Arias","year":"2020","journal-title":"Dig. Liver Dis."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jaci.2011.02.040","article-title":"Eosinophilic esophagitis: Updated consensus recommendations for children and adults","volume":"128","author":"Liacouras","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13223-018-0313-2","article-title":"Mediastinal abscess, an unusual way of presentation of eosinophilic esophagitis","volume":"15","author":"Gisasola","year":"2019","journal-title":"Allergy Asthma Clin. Immunol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"rjz190","DOI":"10.1093\/jscr\/rjz190","article-title":"Spontaneous transmural perforation in eosinophilic esophagitis: Rare case presentation and role of esophageal stenting","volume":"2019","author":"Issa","year":"2019","journal-title":"J. Surg. Case Rep."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1136\/flgastro-2019-101313","article-title":"Eosinophilic oesophagitis: Recent advances and practical management","volume":"12","author":"Attwood","year":"2021","journal-title":"Frontline Gastroenterol."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/9\/1374\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T20:26:28Z","timestamp":1778531188000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/9\/1374"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,30]]},"references-count":93,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["diagnostics16091374"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics16091374","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,30]]}}}