{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T12:08:23Z","timestamp":1778501303694,"version":"3.51.4"},"reference-count":33,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: Gated cardiac positron emission tomography (PET) synchronizes PET data to the cardiac cycle based on an electrocardiogram (ECG) signal, providing left ventricular (LV) functional and geometrical parameters. Nevertheless, image artifacts, due to cardiac-, breathing-, and\/or patient-motion occurring during image acquisition, undermine the reliability and clinical utility of these parameters. This study aims to elucidate the effect of two motion correction (MC) tools, CardioFreeze (CF) and a data-driven motion correction (DDMC) prototype, on LV functional and geometrical parameters. Methods: ECG-gated rest\/stress [13N]NH3 PET\/CT scans from forty patients with myocardial ischemia and thirty-nine patients with normal myocardial perfusion were included. The following four reconstructions were performed for each patient scan: without motion correction (NMC), with CF, DDMC, and DDMC &amp; CF. Images were processed with Cedars-Sinai QPET software. Results: End-diastolic volume (EDV) in rest and stress increased significantly using DDMC. End-systolic volume (ESV) increased significantly, while LV ejection fraction (LVEF) decreased significantly using any MC tool, regardless of the phase. Shape index end-systole (SI ES) and shape-index end-diastole (SI ED) increased significantly when using MC, except for SI ED in rest, where DDMC did not cause any difference. Eccentricity index end-systole (ECC ES) in rest and stress increased significantly in patients with normal myocardial perfusion, while it did not differ in ischemic patients after applying MC. Conclusions: MC tools significantly increase ESV values and decrease EF values. The highest effect is observed with the combined use of DDMC &amp; CF. Image quality is greatly improved when using MC, regardless of the method, particularly in patients with the highest myocardial displacement.<\/jats:p>","DOI":"10.3390\/diagnostics16091377","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T09:33:17Z","timestamp":1777627997000},"page":"1377","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Role of Motion Correction Tools in Left Ventricular Functional Parameters Measured by Gated [13N]NH3 PET\/CT"],"prefix":"10.3390","volume":"16","author":[{"given":"Tonantzin Samara","family":"Martinez-Lucio","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1089-2981","authenticated-orcid":false,"given":"Remco J. J.","family":"Knol","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Northwest Clinics Alkmaar, 1815 JD Alkmaar, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar I.","family":"Mendoza-Iba\u00f1ez","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands"},{"name":"Department of Nuclear Medicine, Northwest Clinics Alkmaar, 1815 JD Alkmaar, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars van","family":"Wunnik","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Northwest Clinics Alkmaar, 1815 JD Alkmaar, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friso M. van der","family":"Zant","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Northwest Clinics Alkmaar, 1815 JD Alkmaar, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4971-2477","authenticated-orcid":false,"given":"Charalampos","family":"Tsoumpas","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5565-1164","authenticated-orcid":false,"given":"Riemer H. J. A.","family":"Slart","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands"},{"name":"Department of Biomedical Photonic Imaging, University of Twente, 7522 NB Enschede, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5772-9900","authenticated-orcid":false,"given":"Sergiy V.","family":"Lazarenko","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Northwest Clinics Alkmaar, 1815 JD Alkmaar, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.1093\/eurheartj\/ehae177","article-title":"2024 ESC Guidelines for the management of chronic coronary syndromes: Developed by the task force for the management of chronic coronary syndromes of the European Society of Cardiology (ESC) Endorsed by the European Association for Cardio-Thoracic Surgery (EACTS)","volume":"45","author":"Vrints","year":"2024","journal-title":"Eur. Heart J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.pcad.2025.09.002","article-title":"SPECT Myocardial Perfusion Imaging in the Era of PET and Multimodality Imaging: Challenges and Opportunities","volume":"93","author":"Alwan","year":"2025","journal-title":"Prog. Cardiovasc. Dis."},{"key":"ref_3","first-page":"179","article-title":"Gated Myocardial Perfusion SPECT: Basic Principles, Technical Aspects, and Clinical Applications","volume":"32","author":"Paul","year":"2004","journal-title":"J. Nucl. Med. Technol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cpet.2018.12.008","article-title":"Gating Approaches in Cardiac PET Imaging","volume":"2","author":"Lassen","year":"2019","journal-title":"PET Clin."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1161\/01.CIR.76.1.44","article-title":"Left ventricular end-systolic volume as the major determinant of survival after recovery from myocardial infarction","volume":"76","author":"White","year":"1987","journal-title":"Circulation"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/S0002-9149(80)80002-6","article-title":"Left ventricular ejection fraction determined by radionuclide ventriculography in early stages of first transmural myocardial infarction. Relation to short-term prognosis","volume":"45","author":"Shah","year":"1980","journal-title":"Am. J. Cardiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1161\/01.CIR.100.10.1035","article-title":"Incremental prognostic value of post-stress left ventricular ejection fraction and volume by gated myocardial perfusion single photon emission computed tomography","volume":"100","author":"Sharir","year":"1999","journal-title":"Circulation"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/S0735-1097(84)80045-5","article-title":"Left ventricular dysfunction after acute myocardial infarction: Results of a prospective multicenter study","volume":"4","author":"Greenberg","year":"1984","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Multicenter Postinfarction Research Group (1983). Risk stratification and survival after myocardial infarction. N. Engl. J. Med., 309, 331\u2013336.","DOI":"10.1056\/NEJM198308113090602"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Wang, J., Bermudez, D., Chen, W., Durgavarjhula, D., Randell, C., Uyanik, M., and McMillan, A. (2024). Motion-correction strategies for enhancing whole-body PET imaging. Front. Nucl. Med., 4.","DOI":"10.3389\/fnume.2024.1257880"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s11886-017-0825-2","article-title":"Enhancing Cardiac PET by Motion Correction Techniques","volume":"19","author":"Rubeaux","year":"2017","journal-title":"Curr. Cardiol. Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s00259-009-1252-4","article-title":"Dual-gated cardiac PET-clinical feasibility study","volume":"37","author":"Teras","year":"2010","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Mendoza-Iba\u00f1ez, O.I., Slart, R.H.J.A., Alexanderson-Rosas, E., Martinez-Lucio, T.S., van der Zant, F.M., Knol, R.J.J., and Lazarenko, S.V. (2025). Inter-Software Reproducibility of Quantitative Values of Myocardial Blood Flow and Coronary Flow Reserve Acquired by [13N]NH3 MPI PET\/CT and the Effect of Motion Correction Tools. Diagnostics, 15.","DOI":"10.3390\/diagnostics15050613"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"6474","DOI":"10.1118\/1.4754586","article-title":"Analysis and comparison of two methods for motion correction in PET imaging","volume":"39","author":"Polycarpou","year":"2012","journal-title":"Med. Phys."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1007\/s00259-005-1846-4","article-title":"Motion detection and correction for dynamic (15)O-water myocardial perfusion PET studies","volume":"32","author":"Naum","year":"2005","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1007\/s00259-007-0374-9","article-title":"Dual cardiac-respiratory gated PET: Implementation and results from a feasibility study","volume":"34","author":"Zikic","year":"2007","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1118\/1.2748104","article-title":"Respiratory gating in positron emission tomography: A quantitative comparison of different gating schemes","volume":"34","author":"Dawood","year":"2007","journal-title":"Med. Phys."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"674","DOI":"10.2967\/jnumed.108.059204","article-title":"List mode-driven cardiac and respiratory gating in PET","volume":"50","author":"Buther","year":"2009","journal-title":"J. Nucl. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1007\/s00259-020-05046-9","article-title":"EANM procedural guidelines for PET\/CT quantitative myocardial perfusion imaging","volume":"48","author":"Lubberink","year":"2021","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s41824-018-0029-z","article-title":"Myocardial blood flow and myocardial flow reserve values in 13N\u2013ammonia myocardial perfusion PET\/CT using a time-efficient protocol in patients without coronary artery disease","volume":"2","author":"Tsj","year":"2018","journal-title":"Eur. J. Hybrid Imaging"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1007\/s12350-018-1262-3","article-title":"The continual innovation of commercial PET\/CT solutions in nuclear cardiology: Siemens Healthineers","volume":"25","author":"Bendriem","year":"2018","journal-title":"J. Nucl. Cardiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"012505","DOI":"10.1118\/1.4770276","article-title":"A mass conservation-based optical flow method for cardiac motion correction in 3D-PET","volume":"40","author":"Dawood","year":"2013","journal-title":"Med. Phys."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s12350-020-02177-2","article-title":"A preliminary evaluation of a high temporal resolution data-driven motion correction algorithm for rubidium-82 on a SiPM PET-CT system","volume":"29","author":"Armstrong","year":"2022","journal-title":"J. Nucl. Cardiol."},{"key":"ref_24","first-page":"749","article-title":"Quantitative LVEF and Qualitative Regional Function from Gated Thallium-201 Perfusion SPECT","volume":"38","author":"Germano","year":"1997","journal-title":"J. Nucl. Med."},{"key":"ref_25","first-page":"2138","article-title":"Automatic Quantification of Ejection Fraction from Gated Myocardial Perfusion SPECT","volume":"36","author":"Germano","year":"1995","journal-title":"J. Nucl. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.nuclcard.2006.05.020","article-title":"Left ventricular shape index assessed by gated stress myocardial perfusion SPECT: Initial description of a new variable","volume":"13","author":"Abidov","year":"2006","journal-title":"J. Nucl. Cardiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s12350-017-0777-3","article-title":"Left ventricular eccentricity index measured with SPECT myocardial perfusion imaging: An additional parameter of adverse cardiac remodeling","volume":"27","author":"Gimelli","year":"2020","journal-title":"J. Nucl. Cardiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.nuclcard.2007.06.008","article-title":"Quantitation in gated perfusion SPECT imaging: The Cedars-Sinai approach","volume":"14","author":"Germano","year":"2007","journal-title":"J. Nucl. Cardiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.2967\/jnumed.118.215418","article-title":"Performance Characteristics of the Digital Biograph Vision PET\/CT System","volume":"60","author":"Schaar","year":"2019","journal-title":"J. Nucl. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"4496","DOI":"10.1088\/1361-6560\/aa6417","article-title":"Enhancing ejection fraction measurement through 4D respiratory motion compensation in cardiac PET imaging","volume":"62","author":"Tang","year":"2017","journal-title":"Phys. Med. Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1007\/s12350-019-01613-2","article-title":"Data-driven, projection-based respiratory motion compensation of PET data for cardiac PET\/CT and PET\/MR imaging","volume":"27","author":"Lassen","year":"2020","journal-title":"J. Nucl. Cardiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1007\/s12350-022-03029-x","article-title":"Left ventricular function and volumes from gated [(13)N]-ammonia positron emission tomography myocardial perfusion imaging: A prospective head-to-head comparison against CMR using a hybrid PET\/MR device","volume":"30","author":"Maurer","year":"2023","journal-title":"J. Nucl. Cardiol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Mendoza-Iba\u00f1ez, O.I., Slart, R.H.J.A., Hayden, C., Mart\u00ednez-Lucio, T.S., van der Zant, F.M., Knol, R.J.J., and Lazarenko, S.V. (2026). Data-Driven Motion Correction Algorithm: Validation in [13N]NH3 Dynamic PET\/CT Scans. J. Clin. Med., 15.","DOI":"10.3390\/jcm15030984"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/9\/1377\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:13:49Z","timestamp":1778498029000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/9\/1377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,1]]},"references-count":33,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["diagnostics16091377"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics16091377","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,1]]}}}