{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T09:12:50Z","timestamp":1778145170760,"version":"3.51.4"},"reference-count":25,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Objective: This study aimed to describe gestational age-specific biometric and estimated fetal weight (EFW) patterns derived from a multicenter cohort of fetuses with gastroschisis and to evaluate the agreement between prenatal EFW and birth weight. Methods: This retrospective study included singleton pregnancies with a prenatal diagnosis of gastroschisis and at least two ultrasound evaluations between 20 and 37 weeks. Data were collected from four Brazilian tertiary centers between 2010 and 2024. Biometric parameters (biparietal diameter, head circumference [HC], abdominal circumference, and femur length) and EFW were recorded. EFW was calculated using Hadlock IV and Siemer formulas. Polynomial regression models were applied to generate gestational age-specific curves for HC, femur length (FL), and EFW. Agreement between prenatal EFW and birth weight (in cases assessed within 14 days of delivery) was analyzed using Bland\u2013Altman plots and the concordance correlation coefficient (CCC). Results: A total of 116 pregnancies and 355 ultrasound tests were included. Polynomial models showed a strong association between gestational age and EFW (R2 = 0.837 for Siemer; R2 = 0.728 for Hadlock), HC (R2 = 0.849), and FL (R2 = 0.877). The 50th percentile curves for gastroschisis were consistently lower than those from standard growth charts. In the birthweight concordance analysis (n = 46), the Siemer formula showed low agreement (CCC = 0.55), while the Hadlock formula showed even lower concordance (CCC = 0.44), with both formulas underestimating actual birth weight. Conclusions: Fetuses with gastroschisis have distinct growth patterns not captured by standard references. Tailored growth curves and careful interpretation of EFW are essential to improve prenatal assessment in this population.<\/jats:p>","DOI":"10.3390\/diagnostics16091402","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T08:01:39Z","timestamp":1778140899000},"page":"1402","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gestational Age-Specific Biometric and Estimated Fetal Weight Curves in Gastroschisis: A Brazilian Multicenter Cohort Study"],"prefix":"10.3390","volume":"16","author":[{"given":"Karina Felippe Monezi","family":"Pontes","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Paulista School of Medicine\u2014Federal University of S\u00e3o Paulo (EPM-UNIFESP), S\u00e3o Paulo 04023-062, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8739-4115","authenticated-orcid":false,"given":"Liliam Cristine","family":"Rolo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Paulista School of Medicine\u2014Federal University of S\u00e3o Paulo (EPM-UNIFESP), S\u00e3o Paulo 04023-062, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6694-6569","authenticated-orcid":false,"given":"Gustavo Yano","family":"Callado","sequence":"additional","affiliation":[{"name":"Faculdade Israelita de Ci\u00eancias da Sa\u00fade Albert Einstein, Hospital Israelita Albert Einstein, S\u00e3o Paulo 05652-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1655-3609","authenticated-orcid":false,"given":"Alberto Borges","family":"Peixoto","sequence":"additional","affiliation":[{"name":"Gynecology and Obstetrics Service, Mario Palm\u00e9rio University Hospital\u2014University of Uberaba (UNIUBE), Uberaba 38055-500, Brazil"},{"name":"Department of Obstetrics and Gynecology, Federal University of Tri\u00e2ngulo Mineiro (UFTM), Uberaba 38025-440, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2312-0932","authenticated-orcid":false,"given":"Manoel","family":"Sarno","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Federal University of Bahia (UFBA), Salvador 40055-150, Brazil"},{"name":"Caliper\u2014School of Image, Salvador 41810-012, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7039-2052","authenticated-orcid":false,"given":"Alex Sandro Rolland","family":"Souza","sequence":"additional","affiliation":[{"name":"Service of Fetal Medicine, Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife 50070-555, Brazil"},{"name":"Academic Area of Gynecology and Obstetrics, Federal University of Pernambuco (UFPE), Recife 50670-420, Brazil"},{"name":"School of Health and Life Sciences, Catholic University of Pernambuco (UNICAP), Recife 50050-410, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6400-4479","authenticated-orcid":false,"given":"Francisco Herl\u00e2nio Costa","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Federal University of Cear\u00e1 (UFC), Fortaleza 60430-270, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2942-6182","authenticated-orcid":false,"given":"Antonio","family":"Braga","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, School of Medicine, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 22240-003, Brazil"},{"name":"Department of General and Specialized Surgery, School of Medicine and Surgery, Federal University of the State of Rio de Janeiro (UNIRIO), Rio de Janeiro 22290-240, Brazil"},{"name":"Postgraduate Program in Applied Health Sciences, University of Vassouras (Univassouras), Vassouras 27700-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Araujo J\u00fanior","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Paulista School of Medicine\u2014Federal University of S\u00e3o Paulo (EPM-UNIFESP), S\u00e3o Paulo 04023-062, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1002\/pd.4562","article-title":"Peripartum and neonatal outcomes of small-for-gestational-age infants with gastroschisis","volume":"35","author":"Girsen","year":"2015","journal-title":"Prenat. 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