{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T05:07:17Z","timestamp":1778908037193,"version":"3.51.4"},"reference-count":33,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: Maintenance hemodialysis patients are particularly vulnerable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This study aimed to evaluate clinical outcomes and identify admission laboratory biomarkers associated with in-hospital mortality in hospitalized hemodialysis patients with coronavirus disease 2019 (COVID-19). Methods: We conducted a retrospective observational study including 130 adult hemodialysis patients with confirmed SARS-CoV-2 infection. Clinical characteristics and admission laboratory parameters were analyzed in relation to in-hospital outcomes using comparative, multivariable logistic regression, and receiver operating characteristic (ROC) curve analyses. Results: The overall in-hospital mortality rate was 34.6%. The median age of the cohort was 66 years, with 64.6% male patients. Non-survivors showed significantly higher levels of inflammatory and tissue-injury markers, including C-reactive protein (CRP) (p &lt; 0.001) and lactate dehydrogenase (LDH) (p &lt; 0.001), together with lower serum albumin (p &lt; 0.001), platelet count (p &lt; 0.001), and lymphocyte levels (p = 0.03). In multivariable analysis, cardiovascular disease, respiratory disease, dyspnea, and ambulatory origin were independently associated with mortality. ROC analysis identified platelet count as the best individual predictor (area under the curve [AUC] = 0.767). An exploratory composite risk score demonstrated excellent discriminative performance (AUC = 0.902). Conclusions: Admission inflammatory and hematological biomarkers are strongly associated with adverse outcomes in hospitalized hemodialysis patients with COVID-19. The integration of clinical and laboratory parameters into a composite risk score may improve early risk stratification and support clinical decision-making in this high-risk population.<\/jats:p>","DOI":"10.3390\/diagnostics16101498","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T13:04:09Z","timestamp":1778763849000},"page":"1498","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Inflammatory Biomarkers and Clinical Outcomes in Hospitalized Hemodialysis Patients with COVID-19: A Retrospective Observational Study"],"prefix":"10.3390","volume":"16","author":[{"given":"Oana","family":"Nicolescu","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8886-970X","authenticated-orcid":false,"given":"Mihaela Magdalena","family":"Mitache","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University Titu Maiorescu Bucharest, Gheorghe Petra\u0219cu 67A, 031592 Bucharest, Romania"},{"name":"Public Health Directorate, Avrig 72-74, District 2, 021578 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei","family":"Mitache","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University Titu Maiorescu Bucharest, Gheorghe Petra\u0219cu 67A, 031592 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8968-504X","authenticated-orcid":false,"given":"Adelina-Gabriela","family":"Niculescu","sequence":"additional","affiliation":[{"name":"Research Institute of the University of Bucharest\u2014ICUB, University of Bucharest, \u0218oseaua Panduri 90, District 5, 050663 Bucharest, Romania"},{"name":"Department of Science and Engineering of Oxide Materials and Nanomaterials, National University of Science and Technology, POLITEHNICA, Splaiul Independen\u021bei 313, District 6, 060042 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragos","family":"Garofil","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Dr. Carol Davila Clinical Hospital of Nephrology, Calea Grivi\u021bei 4, 010731 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor Dan Eugen","family":"Strambu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Dr. Carol Davila Clinical Hospital of Nephrology, Calea Grivi\u021bei 4, 010731 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6987-5137","authenticated-orcid":false,"given":"Bogdan","family":"Oancea","sequence":"additional","affiliation":[{"name":"National Institute of Research and Development for Biological Sciences, 296 Splaiul Independentei, District 6, 060031 Bucharest, Romania"},{"name":"Faculty of Administration and Business, University of Bucharest, Regina Elisabeta 4-12, 030167 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marian","family":"Necula","sequence":"additional","affiliation":[{"name":"National Institute of Research and Development for Biological Sciences, 296 Splaiul Independentei, District 6, 060031 Bucharest, Romania"},{"name":"Faculty of Administration and Business, University of Bucharest, Regina Elisabeta 4-12, 030167 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2409-0966","authenticated-orcid":false,"given":"Corneliu Ovidiu","family":"Vrancianu","sequence":"additional","affiliation":[{"name":"Research Institute of the University of Bucharest\u2014ICUB, University of Bucharest, \u0218oseaua Panduri 90, District 5, 050663 Bucharest, Romania"},{"name":"National Institute of Research and Development for Biological Sciences, 296 Splaiul Independentei, District 6, 060031 Bucharest, Romania"},{"name":"Doctoral School, Carol Davila University of Medicine and Pharmacy, Eroii Sanitari 8, District 5, 050474 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioana Ruxandra","family":"Poiana","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4006-5397","authenticated-orcid":false,"given":"Adrian Radu","family":"Petru","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Dr. Carol Davila Clinical Hospital of Nephrology, Calea Grivi\u021bei 4, 010731 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4807-9470","authenticated-orcid":false,"given":"Ana Maria Alexandra","family":"St\u0103nescu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Academy of Romanian Scientists AOSR, Ilfov Street 3, District 5, 030167 Bucharest, 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