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These techniques\u2014spanning optical, isotopic, and metal-based tracers\u2014have significantly enhanced our ability to detect and monitor ocular diseases, from early-stage pathologies to therapeutic responses. By providing molecular-level specificity, improved signal sensitivity, and real-time dynamic imaging, tracers enable precise analysis of ocular fluid dynamics, retinal and vascular abnormalities, and neural connections between the eye and brain. Furthermore, these technologies are advancing our understanding of the systemic connections between the eye and other organs, such as the brain, thyroid, and lymphatic systems. Tracers are helping to uncover new pathways for understanding these relationships and their impact on both ocular and systemic diseases. Despite challenges in clinical translation, biosafety, and specificity, advances in tracer design, particularly at the nanoscale, are driving the development of multimodal imaging platforms. As these technologies continue to evolve, they will increasingly support the development of tailored treatment regimens, improve early detection, and facilitate the monitoring of therapeutic outcomes.<\/jats:p>","DOI":"10.3390\/diagnostics16111608","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T11:57:44Z","timestamp":1779710264000},"page":"1608","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tracer Techniques in Ophthalmology: Ocular Applications and Systemic Connections"],"prefix":"10.3390","volume":"16","author":[{"given":"Xinxin","family":"Ye","sequence":"first","affiliation":[{"name":"Eye Center of Xiangya Hospital, Central South University, Changsha 410008, China"},{"name":"Hunan Key Laboratory of Ophthalmology, Changsha 410008, China"},{"name":"National Clinical Research Center for Geriatirc Diseases, Xiangya Hospital, Central South University, Changsha 410008, 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