{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T09:04:40Z","timestamp":1780304680429,"version":"3.54.0"},"reference-count":24,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T00:00:00Z","timestamp":1780099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Here, we present the case of a 25-year-old patient with G542X and G85E cystic fibrosis mutations who underwent computed tomography examination before and after triple-combination therapy. Clear improvement in sinonasal and lung involvement is visible two years after modulator treatment initiation. To the best of our knowledge, this is the first report about sinonasal improvement demonstrated by computed tomography images in a patient with G542X\/G85E mutations.<\/jats:p>","DOI":"10.3390\/diagnostics16111692","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T08:09:16Z","timestamp":1780301356000},"page":"1692","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sinonasal and Pulmonary Computed Tomography Images Before and After Triple-Combination Therapy in a Patient with Cystic Fibrosis Without \u0394F508 Mutations"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4630-1090","authenticated-orcid":false,"given":"Corrado","family":"Tagliati","sequence":"first","affiliation":[{"name":"AST Ancona, Ospedale di Comunit\u00e0 Maria Montessori di Chiaravalle, Via Fratelli Rosselli 176, 60033 Chiaravalle, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Campagna","sequence":"additional","affiliation":[{"name":"Dipartimento Materno Infantile, UOSD Centro di Riferimento Regionale Fibrosi Cistica, Ospedale \u201cSan Liberatore\u201d, Viale Risorgimento, 64032 Atri, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Di Sabatino","sequence":"additional","affiliation":[{"name":"Dipartimento Materno Infantile, UOSD Centro di Riferimento Regionale Fibrosi Cistica, Ospedale \u201cSan Liberatore\u201d, Viale Risorgimento, 64032 Atri, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Lanni","sequence":"additional","affiliation":[{"name":"Dipartimento dei Servizi, UOSD Radiologia Ospedale \u201cSan Liberatore\u201d, Viale Risorgimento, 64032 Atri, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Battista","sequence":"additional","affiliation":[{"name":"Dipartimento dei Servizi, UOSD Radiologia Ospedale \u201cSan Liberatore\u201d, Viale Risorgimento, 64032 Atri, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0789-2745","authenticated-orcid":false,"given":"Pietro","family":"Ripani","sequence":"additional","affiliation":[{"name":"Dipartimento Materno Infantile, UOSD Centro di Riferimento Regionale Fibrosi Cistica, Ospedale \u201cSan Liberatore\u201d, Viale Risorgimento, 64032 Atri, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1056\/NEJMra2216474","article-title":"Cystic Fibrosis","volume":"389","author":"Grasemann","year":"2023","journal-title":"N. 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