{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T01:56:47Z","timestamp":1781143007519,"version":"3.54.1"},"reference-count":20,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: CT-guided lung biopsy is an essential diagnostic procedure but is associated with complications such as pneumothorax and pulmonary hemorrhage. While patient- and lesion-related factors are well established, operator-modifiable parameters remain less clearly defined. This study aimed to evaluate complication rates and identify independent predictors, with a particular focus on modifiable procedural factors. Methods: This retrospective study included 309 consecutive patients undergoing CT-guided transthoracic lung biopsy. Patient, lesion, and procedural variables\u2014including needle\u2013pleura angle and patient positioning\u2014were analyzed. Complications were classified according to the Society of Interventional Radiology (SIR) system. Multivariate logistic regression analyses were performed to identify independent predictors. Results: Complications occurred in 20.4% of patients, with pneumothorax (14.2%) and hemorrhage (4.9%) being the most frequent. A needle angle \u2264 65\u00b0 was independently associated with major complications (OR = 8.12, p = 0.025). Perilesional emphysema (OR = 19.38, p = 0.004) and pleural effusion (OR = 30.72, p = 0.001) were also strong predictors. Supine positioning significantly increased hemorrhage risk (OR = 9.03, p = 0.043). Conclusions: Operator-modifiable factors, particularly needle angle and patient positioning, may influence complication risk. Optimization of these parameters may provide a practical approach to improving procedural safety in CT-guided lung biopsy.<\/jats:p>","DOI":"10.3390\/diagnostics16121792","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:48:35Z","timestamp":1781138915000},"page":"1792","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Procedural Optimization in CT-Guided Lung Biopsy: Impact of Needle Angle and Patient Positioning on Complication Rates"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2054-1571","authenticated-orcid":false,"given":"Erkan","family":"Bilgin","sequence":"first","affiliation":[{"name":"Department of Radiology, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara 06200, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2150-8650","authenticated-orcid":false,"given":"Ahmet","family":"Bayrak","sequence":"additional","affiliation":[{"name":"Department of Radiology, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara 06200, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2111-6294","authenticated-orcid":false,"given":"\u00c7etin","family":"\u0130mamo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara 06200, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezel","family":"Yalt\u0131r\u0131k Bilgin","sequence":"additional","affiliation":[{"name":"Department of Radiology, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara 06200, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alm\u0131la","family":"Co\u015fkun Bilge","sequence":"additional","affiliation":[{"name":"Department of Radiology, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara 06200, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif","family":"Akta\u015f","sequence":"additional","affiliation":[{"name":"Department of Radiology, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara 06200, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0294-609X","authenticated-orcid":false,"given":"H\u00fcseyin","family":"\u00c7akmak","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara 06200, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banu","family":"\u0130nce Alkan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara 06200, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1159\/000093369","article-title":"The future of bronchoscopy in diagnosing, staging and treatment of lung cancer","volume":"73","author":"Herth","year":"2006","journal-title":"Respiration"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"W678","DOI":"10.2214\/AJR.10.4659","article-title":"Complications of CT-guided percutaneous needle biopsy of the chest: Prevention and management","volume":"196","author":"Wu","year":"2011","journal-title":"Am. 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