{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T06:52:15Z","timestamp":1781765535268,"version":"3.54.5"},"reference-count":112,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Complex Hospitalari Universitari Mois\u00e8s Broggi, Consorci Sanitari Integral"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>IgG4-related disease (IgG4-RD) is a systemic fibroinflammatory disorder characterised by elevated serum levels of IgG4 and multiorgan damage. Its diagnosis is challenging and requires a careful integration of clinical, radiological, serological and histological data. Pancreatic and biliary involvement is one of the most common manifestations of IgG4-RD, presenting as type 1 autoimmune pancreatitis (AIP) and IgG4-related sclerosing cholangitis (IgG4-SC), two entities that often occur synchronously and may mimic malignancy in the form of pancreatic ductal adenocarcinoma (PDAC) and cholangiocarcinoma, respectively. The main objective of this article is to illustrate the key imaging features of AIP and IgG4-SC on computed tomography (CT) and magnetic resonance imaging (MRI), providing a comprehensive review of their current diagnostic criteria and discussing their differential diagnosis with other benign and malignant conditions.<\/jats:p>","DOI":"10.3390\/diagnostics16121806","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T12:14:58Z","timestamp":1781180098000},"page":"1806","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic Imaging of Pancreatic and Biliary Involvement in IgG4-Related Disease: Key Imaging Features, Diagnostic Criteria and Differential Diagnosis"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1928-9778","authenticated-orcid":false,"given":"Javier","family":"Miguez Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Department of Radiology, Complex Hospitalari Universitari Mois\u00e8s Broggi, Consorci Sanitari Integral, 08970 Sant Joan Desp\u00ed, Barcelona, Spain"},{"name":"Department of Medicine, Universitat de Barcelona (UB), 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Oliveira Caiafa","sequence":"additional","affiliation":[{"name":"Department of Radiology, Complex Hospitalari Universitari Mois\u00e8s Broggi, Consorci Sanitari Integral, 08970 Sant Joan Desp\u00ed, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9523-1542","authenticated-orcid":false,"given":"Marc","family":"Valls Mellado","sequence":"additional","affiliation":[{"name":"Department of Radiology, Complex Hospitalari Universitari Mois\u00e8s Broggi, Consorci Sanitari Integral, 08970 Sant Joan Desp\u00ed, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"L\u00f3pez G\u00f3mez","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Complex Hospitalari Universitari Mois\u00e8s Broggi, Consorci Sanitari Integral, 08970 Sant Joan Desp\u00ed, Barcelona, Spain"},{"name":"Department of Medicine, Universitat Aut\u00f2noma de Barcelona (UAB), 08193 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Lozano Arranz","sequence":"additional","affiliation":[{"name":"Department of Radiology, Complex Hospitalari Universitari Mois\u00e8s Broggi, Consorci Sanitari Integral, 08970 Sant Joan Desp\u00ed, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc","family":"Calaf Forn","sequence":"additional","affiliation":[{"name":"Department of Radiology, Complex Hospitalari Universitari Mois\u00e8s Broggi, Consorci Sanitari Integral, 08970 Sant Joan Desp\u00ed, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alona","family":"Thomas Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Radiology, Complex Hospitalari Universitari Mois\u00e8s Broggi, Consorci Sanitari Integral, 08970 Sant Joan Desp\u00ed, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Pelegr\u00ed Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Radiology, Complex Hospitalari Universitari Mois\u00e8s Broggi, Consorci Sanitari Integral, 08970 Sant Joan Desp\u00ed, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Pall\u00e0s Guardiola","sequence":"additional","affiliation":[{"name":"Department of Radiology, Complex Hospitalari Universitari Mois\u00e8s Broggi, Consorci Sanitari Integral, 08970 Sant Joan Desp\u00ed, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena Ivonne","family":"Sarati Nieto","sequence":"additional","affiliation":[{"name":"Department of Radiology, Complex Hospitalari Universitari Mois\u00e8s Broggi, Consorci Sanitari Integral, 08970 Sant Joan Desp\u00ed, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid Carolina","family":"Dur\u00e1n Palacios","sequence":"additional","affiliation":[{"name":"Department of Radiology, Complex Hospitalari Universitari Mois\u00e8s Broggi, Consorci Sanitari Integral, 08970 Sant Joan Desp\u00ed, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang\u00e9lica Mar\u00eda","family":"Herrera Pulido","sequence":"additional","affiliation":[{"name":"Department of Radiology, Complex Hospitalari Universitari Mois\u00e8s Broggi, Consorci Sanitari Integral, 08970 Sant Joan Desp\u00ed, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Gonz\u00e1lez Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Hepatobiliopancreatic Unit, Department of General and Digestive Surgery, Complex Hospitalari Universitari Mois\u00e8s Broggi, Consorci Sanitari Integral, 08970 Sant Joan Desp\u00ed, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Catal\u00e0 Forteza","sequence":"additional","affiliation":[{"name":"Department of Radiology, Complex Hospitalari Universitari Mois\u00e8s Broggi, Consorci Sanitari Integral, 08970 Sant Joan Desp\u00ed, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/s41584-025-01240-x","article-title":"IgG4-related disease and other fibro-inflammatory 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