{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T10:52:55Z","timestamp":1781607175338,"version":"3.54.5"},"reference-count":31,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: Cervical self-sampling is increasingly used for high-risk human papillomavirus (hrHPV) testing, but evidence for integrated liquid-based cytology (LBC) and sexually transmitted infection (STI) testing is limited. This study evaluated the feasibility and diagnostic agreement of an integrated single-step self-sampling approach for LBC, hrHPV, and STI testing. Methods: In this prospective paired study, 520 Korean women for cervical cancer screening between December 2024 and February 2025 were enrolled. Each participant first underwent cervical self-sampling using Earlypap\u00ae, followed by clinician-collected sampling. Paired specimens were analyzed for LBC, hrHPV, and STI detection. Percentage agreement and Cohen\u2019s kappa coefficients (\u03ba) were calculated. Results: Self-sampling was successful on the first attempt in 98.5% of participants, with 92.1% preferring it over clinician-collection. LSIL was detected in 2.3% of self-collected and 1.2% of clinician-collected specimens, and HSIL was detected in 0.4% of both specimen types. hrHPV positivity was 14.8% in self- and 12.9% in clinician-collected specimens. Ureaplasma spp. were frequently detected, and Candida albicans was identified in approximately 5% of specimens. Overall agreement was 91.7% (\u03ba = 0.67) for LBC, 95.4% (\u03ba = 0.79) for hrHPV, and 97.0% (\u03ba = 0.72) for STI. Conclusions: Integrated cervical self-sampling using a single-step device demonstrated high feasibility and substantial agreement with clinician-based sampling, supporting its potential to improve screening efficiency and reduce participation barriers.<\/jats:p>","DOI":"10.3390\/diagnostics16121863","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T09:06:52Z","timestamp":1781600812000},"page":"1863","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrated Cervical Self-Sampling for Cytology, High-Risk Human Papillomavirus, and Sexually Transmitted Infection Testing: A Prospective Study"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9131-3779","authenticated-orcid":false,"given":"Chang Gok","family":"Woo","sequence":"first","affiliation":[{"name":"Department of Pathology, College of Medicine, Chungbuk National University, Cheongju 28644, Republic of Korea"},{"name":"Department of Pathology, Chungbuk National University Hospital, Cheongju 28644, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaehoon","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Medicine, Chungbuk National University, Cheongju 28644, Republic of Korea"},{"name":"Department of Pathology, Chungbuk National University Hospital, Cheongju 28644, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujin","family":"Im","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Medicine, Chungbuk National University, Cheongju 28644, Republic of Korea"},{"name":"Department of Pathology, Chungbuk National University Hospital, Cheongju 28644, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man Ki","family":"Kim","sequence":"additional","affiliation":[{"name":"Motaean Woman Hospital, Cheongju 28628, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2258-7490","authenticated-orcid":false,"given":"So Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Health Policy and Management, College of Medicine, Chungbuk National University, Cheongju 28644, Republic of Korea"},{"name":"Department of Public Health and Preventive Medicine, Chungbuk National University Hospital, Cheongju 28644, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3247-0827","authenticated-orcid":false,"given":"Jong Hyock","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Public Health and Preventive Medicine, Chungbuk National University Hospital, Cheongju 28644, Republic of Korea"},{"name":"Department of Preventive Medicine, College of Medicine, Chungbuk National University, Cheongju 28644, Republic of Korea"},{"name":"Institutes of Health & Science Convergence, Chungbuk National University, Cheongju 28644, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5350-8751","authenticated-orcid":false,"given":"Ok-Jun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Medicine, Chungbuk National University, Cheongju 28644, Republic of Korea"},{"name":"Department of Pathology, Chungbuk National University Hospital, Cheongju 28644, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Castillo, M., Astudillo, A., Clavero, O., Velasco, J., Ib\u00e1\u00f1ez, R., and de Sanjos\u00e9, S. 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