{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:52:00Z","timestamp":1791910320295,"version":"4.3.4"},"reference-count":23,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: Breast adenoid cystic carcinoma (ACC) is a rare tumor with limited data on imaging features and treatment response. This study investigated the clinical and radiological characteristics of ACC of the breast. Methods: Patients with ACC who underwent surgery at our institution between February 2010 and December 2023 were included. Clinical characteristics, biopsy and surgical pathology findings, and follow-up outcomes were reviewed. Preoperative mammography, ultrasound (US), and MRI findings were analyzed. Results: Twenty-eight women (mean age, 57 \u00b1 8 years) were identified. Half presented with palpable masses, and the remainder were detected on screening. Percutaneous biopsy was performed in 27 patients, correctly diagnosing ACC in 18 (66.7%), whereas 9 (33.3%) were misdiagnosed as having invasive ductal carcinoma. The mean tumor size was 2.9 cm (range, 0.9\u20138 cm), with axillary metastasis in two women (7.1%). Most tumors were triple-negative (78.6%), while six showed low estrogen-receptor positivity (&lt;10%). Ki-67 was &lt;20% in 64.3%, with no high values (\u226575%). Three patients received neoadjuvant chemotherapy, with two non-responders. No recurrences occurred during a median follow-up of 51 months. Imaging revealed masses on mammography (85.2%), US (92.9%), and MRI (92.3%), with calcifications in two cases. Most lesions were highly suspicious (BI-RADS 4C or 5) and showed increased vascularity in 92.3% on Doppler US. Conclusions: Breast ACC typically presents as a hypervascular, highly suspicious mass. Despite frequent triple-negative profiles, it shows low proliferation, poor response to chemotherapy, and favorable prognosis.<\/jats:p>","DOI":"10.3390\/diagnostics16121869","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T01:58:38Z","timestamp":1781661518000},"page":"1869","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Adenoid Cystic Carcinoma of the Breast: Clinical and Radiological Findings"],"prefix":"10.3390","volume":"16","author":[{"given":"Jungmin","family":"Hwang","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, University of Illinois at Chicago, 1200 W Harrison St, Chicago, IL 60607, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boo-Kyung","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun-Sook","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Soo","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4266-7984","authenticated-orcid":false,"given":"Jeongmin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haejung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myoung Kyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunwoo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6679-9650","authenticated-orcid":false,"given":"Eun Young","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.2214\/ajr.171.6.9843312","article-title":"Adenoid cystic carcinoma of the breast: Mammographic appearance and pathologic correlation","volume":"171","author":"Velasco","year":"1998","journal-title":"AJR Am. J. Roentgenol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.2214\/AJR.09.3545","article-title":"Adenoid cystic carcinoma of the breast","volume":"194","author":"Glazebrook","year":"2010","journal-title":"AJR Am. J. Roentgenol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Zhang, W., Fang, Y., Zhang, Z., and Wang, J. (2021). Management of adenoid cystic carcinoma of the breast: A single-institution study. Front. Oncol., 11.","DOI":"10.3389\/fonc.2021.621012"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1177\/0003134820942287","article-title":"Treatment patterns and clinical outcomes of adenoid cystic breast carcinoma: A single-institution experience","volume":"86","author":"Goldbach","year":"2020","journal-title":"Am. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s12282-017-0780-1","article-title":"Adenoid cystic carcinoma of the breast, 20 years of experience in a single center with review of literature","volume":"25","author":"Treitl","year":"2018","journal-title":"Breast Cancer"},{"key":"ref_6","unstructured":"American College of Radiology ACR (2013). BI-RADS Atlas: Breast Imaging Reporting and Data System, Oxford University Press. [5th ed.]."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1136\/jcp.2009.073908","article-title":"Adenoid cystic carcinomas of the breast and salivary glands (or \u201cThe strange case of Dr Jekyll and Mr Hyde\u201d of exocrine gland carcinomas)","volume":"63","author":"Weigelt","year":"2010","journal-title":"J. Clin. Pathol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.pathol.2016.10.011","article-title":"The morphological spectrum of salivary gland type tumours of the breast","volume":"49","author":"Foschini","year":"2017","journal-title":"Pathology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/dc.20015","article-title":"Adenoid cystic carcinoma of the breast diagnosed by fine-needle aspiration","volume":"30","author":"Saqi","year":"2004","journal-title":"Diagn. Cytopathol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1097\/00000478-200204000-00002","article-title":"Solid variant of mammary adenoid cystic carcinoma with basaloid features: A study of nine cases","volume":"26","author":"Shin","year":"2002","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1159\/000517490","article-title":"Ki67 as proliferative marker in patients with early breast cancer and its association with clinicopathological factors","volume":"99","author":"Friedl","year":"2021","journal-title":"Oncology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s00404-015-3859-y","article-title":"An overview of triple-negative breast cancer","volume":"293","author":"Kumar","year":"2016","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4","DOI":"10.21037\/tbcr-24-28","article-title":"Targeting low-risk triple-negative breast cancer: A review on de-escalation strategies for a new era","volume":"6","author":"Carvalho","year":"2025","journal-title":"Transl. Breast Cancer Res."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Lehmann, B.D., Jovanovi\u0107, B., Chen, X., Estrada, M.V., Johnson, K.N., Shyr, Y., Moses, H.L., Sanders, M.E., and Pietenpol, J.A. (2016). Refinement of triple-negative breast cancer molecular subtypes: Implications for neoadjuvant chemotherapy selection. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0157368"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"105760","DOI":"10.1016\/j.humpath.2025.105760","article-title":"Solid basaloid adenoid cystic carcinoma of the breast: A high-grade triple negative breast carcinoma which rarely responds to neoadjuvant chemotherapy","volume":"157","author":"Fan","year":"2025","journal-title":"Hum. Pathol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"108858","DOI":"10.1016\/j.ijscr.2023.108858","article-title":"Solid-basaloid variant of adenoid cystic carcinoma of the breast unresponsive to neoadjuvant chemotherapy: Case report","volume":"111","author":"Hmidi","year":"2023","journal-title":"Int. J. Surg. Case Rep."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3862","DOI":"10.1002\/cncr.34973","article-title":"Persistence of patient-detected breast cancer over time: 1990\u20132019","volume":"129","author":"Malmgren","year":"2023","journal-title":"Cancer"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.clbc.2022.02.008","article-title":"Characteristics, Clinical Differences and Outcomes of Breast Cancer Patients with Negative or Low HER2 Expression","volume":"22","author":"Rosso","year":"2022","journal-title":"Clin. Breast Cancer"},{"key":"ref_19","first-page":"1","article-title":"Adenoid cystic carcinoma of the breast, from diagnosis to management: A case report","volume":"19","author":"Palazuelos","year":"2025","journal-title":"J. Med. Case Rep."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"7579","DOI":"10.12998\/wjcc.v9.i25.7579","article-title":"Breast adenoid cystic carcinoma arising in microglandular adenosis: A case report and review of literature","volume":"9","author":"An","year":"2021","journal-title":"World J. Clin. Cases"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"vi23","DOI":"10.1093\/annonc\/mds191","article-title":"Imaging of triple-negative breast cancer","volume":"23","author":"Dogan","year":"2012","journal-title":"Ann. Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3348\/jksr.2015.72.6.411","article-title":"Radiologic and pathological correlation of adenoid cystic carcinoma of the breast: A case report","volume":"72","author":"Kim","year":"2015","journal-title":"J. Korean Soc. Radiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e230027","DOI":"10.1148\/rg.230027","article-title":"Imaging Challenges in Diagnosing Triple-Negative Breast Cancer","volume":"43","author":"Schopp","year":"2023","journal-title":"Radiographics"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/12\/1869\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T02:22:55Z","timestamp":1781662975000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/12\/1869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,16]]},"references-count":23,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["diagnostics16121869"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics16121869","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,16]]}}}