{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T17:54:30Z","timestamp":1785434070216,"version":"3.56.0"},"reference-count":9,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ping Tung Christian Hospital","award":["PS115010"],"award-info":[{"award-number":["PS115010"]}]},{"award":["PS115010"],"award-info":[{"award-number":["PS115010"]}],"id":[{"id":"https:\/\/ror.org\/04bnbsh26","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Adult intussusception is an uncommon condition that usually indicates an underlying pathological lead point. Ileal perineurioma is an exceptionally rare benign peripheral nerve sheath tumor with limited gastrointestinal reports. We describe a 59-year-old woman presenting with acute severe abdominal pain, vomiting, and distension. Contrast-enhanced computed tomography demonstrated ileal intussusception with small-bowel obstruction. Emergency laparotomy confirmed terminal ileal intussusception, and segmental resection was performed. Histopathological evaluation revealed a spindle-cell neoplasm with characteristic pseudo-onion bulb architecture. Immunohistochemistry showed strong positivity for epithelial membrane antigen (EMA) and Glucose Transporter-1 (GLUT-1), while other markers were negative, confirming perineurioma. The postoperative course was uneventful, with no recurrence on follow-up. This case highlights ileal perineurioma as a rare but important differential diagnosis in adult small-bowel intussusception, with definitive diagnosis reliant on histopathological and immunohistochemical evaluation.<\/jats:p>","DOI":"10.3390\/diagnostics16121882","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T08:22:56Z","timestamp":1781684576000},"page":"1882","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Rare Adult Ileal Intussusception Caused by Perineurioma"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8921-2912","authenticated-orcid":false,"given":"Yoen Young","family":"Chuah","sequence":"first","affiliation":[{"name":"Department of Biological Science, College of Sciences, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan"},{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Ping Tung Christian Hospital, Ping Tung 90059, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seng-Wei","family":"Ooi","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Internal Medicine, Far-Eastern Memorial Hospital, Taipei 220216, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Peng","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ping Tung Christian Hospital, Ping Tung 90059, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Sheng","family":"Tzeng","sequence":"additional","affiliation":[{"name":"Department of Radiology, Ping Tung Christian Hospital, Ping Tung 90059, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6486-7717","authenticated-orcid":false,"given":"Yeong Yeh","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kota Bahru 16150, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yow-Ling","family":"Shiue","sequence":"additional","affiliation":[{"name":"Department of Biological Science, College of Sciences, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan"},{"name":"Institute of Biomedical Sciences, College of Medicine, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Ming","family":"Tu","sequence":"additional","affiliation":[{"name":"Division of Colorectal Surgery, Department of Surgery, Ping Tung Christian Hospital, Ping Tung 90059, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Yao","family":"Liao","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei 111045, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1097\/00000478-198809000-00004","article-title":"Immunohistochemical detection of epithelial membrane antigen in normal perineurial cells and perineurioma","volume":"12","author":"Ariza","year":"1988","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1365-2559.1988.tb02022.x","article-title":"Epithelial membrane antigen expression by the perineurium of peripheral nerve and in peripheral nerve tumours","volume":"13","author":"Theaker","year":"1988","journal-title":"Histopathology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1097\/01.pas.0000155166.86409.d2","article-title":"Soft tissue perineurioma: Clinicopathologic analysis of 81 cases including those with atypical histologic features","volume":"29","author":"Hornick","year":"2005","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1097\/01.pas.0000154130.87219.2c","article-title":"Intestinal perineuriomas: Clinicopathologic definition of a new anatomic subset in a series of 10 cases","volume":"29","author":"Hornick","year":"2005","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1097\/01.pas.0000213278.53338.7b","article-title":"Perineurioma versus fibroblastic polyp of the colon","volume":"30","author":"Zamecnik","year":"2006","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13000-018-0694-z","article-title":"Colonic perineurioma (benign fibroblastic polyp): Case report and review of the literature","volume":"13","author":"Rigby","year":"2018","journal-title":"Diagn. Pathol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1636142","DOI":"10.1155\/crgm\/1636142","article-title":"Gastrointestinal tract perineuriomas and benign fibroblastic polyps: Case report and comprehensive systematic review","volume":"2025","author":"Alenezi","year":"2025","journal-title":"Case Rep. Gastrointest. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"407","DOI":"10.3748\/wjg.15.407","article-title":"Intussusception of the bowel in adults: A review","volume":"15","author":"Marinis","year":"2009","journal-title":"World J. Gastroenterol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1590\/S1516-31802011000100010","article-title":"Ileal perineurioma as a cause of intussusception","volume":"129","author":"Wludarski","year":"2011","journal-title":"Sao Paulo Med. J."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/12\/1882\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T08:53:50Z","timestamp":1781686430000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/12\/1882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,17]]},"references-count":9,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["diagnostics16121882"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics16121882","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,17]]}}}