{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T16:53:41Z","timestamp":1794329621951,"version":"4.9.0"},"reference-count":24,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/objectives: Catheter-related bloodstream infection (CRBSI) is a frequent and morbid complication in catheter-dependent maintenance hemodialysis, and rapid risk stratification is needed while awaiting cultures. This study aimed to evaluate admission complete blood count-derived indices\u2014neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and pan-immune-inflammation value (PIV)\u2014for identifying CRBSI. Methods: This single-center retrospective study (1 January 2011\u201331 October 2024) included adult catheter-dependent hemodialysis patients classified as CRBSI or controls. CRBSI required compatible clinical findings and concordant growth of the same microorganism(s) in paired simultaneous catheter and peripheral blood cultures. Controls were hospitalized for non-infectious reasons without infection during the index admission. Indices were calculated from admission blood counts. Discrimination was assessed using ROC analysis, and adjusted associations were evaluated using multivariable logistic regression. Results: Among 286 patients (147 CRBSI, 139 controls), CRBSI cases had higher NLR, SII, and PIV and lower LMR; PLR did not differ. NLR showed the numerically highest discriminatory performance among the evaluated indices (AUC 0.737; cut-off 5.96; sensitivity 68.7%, specificity 68.3%; p &lt; 0.001). SII (cut-off 1189.21; AUC 0.693) and PIV (cut-off 821.62; AUC 0.686) had moderate discrimination, and LMR was modest (cut-off 1.65; AUC 0.642); PLR was not discriminatory (AUC 0.559; p = 0.086). In models adjusted for age, sex, hypertension, and cardiovascular disease, NLR remained associated with CRBSI (OR 1.159; p &lt; 0.001), together with hypertension (OR 2.441; p = 0.017) and cardiovascular disease (OR 2.626; p &lt; 0.001). Conclusions: Admission hematologic inflammation indices, particularly NLR, showed moderate ability to discriminate CRBSI from non-infectious admissions in catheter-dependent hemodialysis patients and may provide rapid adjunctive information while awaiting microbiological confirmation.<\/jats:p>","DOI":"10.3390\/diagnostics16121907","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T13:04:04Z","timestamp":1781874244000},"page":"1907","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Adjunctive Value of Admission CBC-Derived Inflammation Indices for Catheter-Related Bloodstream Infection in Catheter-Dependent Hemodialysis Patients: A Retrospective Case\u2013Control Study"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9203-2285","authenticated-orcid":false,"given":"Muhammed Ali","family":"Co\u015fkuner","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Antalya City Hospital, 07080 Antalya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6khan","family":"K\u00f6ker","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Antalya Training and Research Hospital, 07100 Antalya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fclhan \u00d6z\u00e7elik","family":"K\u00f6ker","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Faculty of Medicine, Akdeniz University, 07070 Antalya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0773-7000","authenticated-orcid":false,"given":"Gizem Zorlu","family":"G\u00f6rg\u00fcl\u00fcgil","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Antalya Training and Research Hospital, 07100 Antalya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6kay","family":"G\u00fcven","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Antalya Training and Research Hospital, 07100 Antalya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasin","family":"\u015eahint\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Antalya Training and Research Hospital, 07100 Antalya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5795-533X","authenticated-orcid":false,"given":"Bilgin Bahad\u0131r","family":"Ba\u015fg\u00f6z","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Antalya City Hospital, 07080 Antalya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u00e7a","family":"\u0130nci","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Antalya Training and Research Hospital, 07100 Antalya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derya","family":"Seyman","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Antalya Training and Research Hospital, 07100 Antalya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,19]]},"reference":[{"key":"ref_1","unstructured":"United States Renal Data System (2025). 2025 USRDS Annual Data Report: Epidemiology of Kidney Disease in the United States, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health."},{"key":"ref_2","unstructured":"Centers for Disease Control and Prevention (2026, January 22). 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