{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T15:51:41Z","timestamp":1781884301723,"version":"3.54.5"},"reference-count":99,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: This review describes the advantages of new photonic-based approaches for assessing the activity of caries lesions. Many lesions have been arrested or are non-carious developmental defects, such as fluorosis, which do not require intervention. New methods are needed to assess lesion activity and avoid unnecessary removal of the tooth structure. Methods: At present, there are no reliable methods for assessing lesion activity in vivo. Nondestructive optical monitoring of lesion structure and the changes in light scattering that occur during drying offer the potential for lesion activity assessment during a single examination. Since optical diagnostic instruments exploit changes in the porosity and the permeability of the lesion, they have the potential to assess whether lesions are active and expanding or arrested and undergoing remineralization. Optical coherence tomography (OCT), Raman imaging and fluorescence loss, thermal and short-wavelength infrared (SWIR) reflectance measurements during lesion dehydration with forced air are presented. Results: Clinical studies have shown that optical coherence tomography is capable of showing distinct structural differences between active and arrested lesions on coronal and root surfaces. Differences in the kinetics of dehydration measured using reflectance measurements at SWIR wavelengths coincident with water absorption bands also show great potential. Conclusions: OCT and dehydration imaging at SWIR wavelengths have great potential for assessing lesion activity since they can also be used for caries screening, are safe for frequent monitoring and do not require the application of external agents.<\/jats:p>","DOI":"10.3390\/diagnostics16121908","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:37:42Z","timestamp":1781879862000},"page":"1908","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Photonic Methods for the Assessment of Lesion Activity"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5327-2558","authenticated-orcid":false,"given":"Daniel","family":"Fried","sequence":"first","affiliation":[{"name":"Department of Preventive and Restorative Dental Sciences, University of California, San Francisco, 707 Parnassus Ave, San Francisco, CA 94143, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,19]]},"reference":[{"key":"ref_1","unstructured":"Dye, B.A., Thornton-Evans, T., Li, X., and Iafolla, T.J. (2015). Dental Caries and Tooth Loss in Adults in the United States, 2011\u20132012; NCHS Data Brief, #197, National Center for Health Statistics."},{"key":"ref_2","unstructured":"National Institute of Dental and Craniofacial Research (2021). Oral Health in America:Advances and Challenges, US Department of Health and Human Services."},{"key":"ref_3","unstructured":"Fejerskov, O., Nyvad, B., and Kidd, E. (2015). Dental Caries: The Disease and its Clinical Management, Wiley Blackwell."},{"key":"ref_4","unstructured":"White, S.C., and Pharoah, M.J. (2014). Oral Radiology: Principles and Interpretation, Mosby."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.cden.2005.05.010","article-title":"Utility of radiology, laser fluorescence, and transillumination","volume":"49","author":"Yang","year":"2005","journal-title":"Dent. Clin. North. Am."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Zandona, A.F., and Longbottom, C. (2019). Near-Infrared Reflectance Imaging of Dental Caries. Detection and Assessment of Dental Caries, Springer.","DOI":"10.1007\/978-3-030-16967-1"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Zandona, A.F., and Longbottom, C. (2019). Optical Coherence Tomography for Imaging Dental Caries. Detection and Assessment of Dental Caries, Springer.","DOI":"10.1007\/978-3-030-16967-1"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1002\/lsm.22549","article-title":"Near-IR Transillumination and Reflectance Imaging at 1300-nm and 1500-1700-nm for in vivo Caries Detection","volume":"48","author":"Simon","year":"2016","journal-title":"Lasers Surg. Med."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Zhu, Y., Le, O., Xue, J., Wycoff, S., and Fried, D. (2024). Clinical SWIR and CP-OCT imaging of interproximal lesions. BMC Oral. Health, 24.","DOI":"10.1186\/s12903-024-04637-4"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Pitts, N. (2009). Detection, Assessment, Diagnosis and Monitoring of Caries, Karger.","DOI":"10.1159\/isbn.978-3-8055-9185-0"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jdent.2017.11.004","article-title":"Dentists' decision strategies for suspicious occlusal caries lesions in a National Dental PBRN study","volume":"69","author":"Makhija","year":"2018","journal-title":"J. Dent."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.adaj.2017.08.009","article-title":"Surface characteristics and lesion depth and activity of suspicious occlusal carious lesions: Findings from The National Dental Practice-Based Research Network","volume":"148","author":"Makhija","year":"2017","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"105352","DOI":"10.1016\/j.jdent.2024.105352","article-title":"Quantitative assessment of early caries lesion activity using novel dye-enhanced fluorescence imaging","volume":"150","author":"Park","year":"2024","journal-title":"J. Dent."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1002\/cre2.400","article-title":"Clinical validation of a novel bioluminescence imaging technology for aiding the assessment of carious lesion activity status","volume":"7","author":"Pitts","year":"2021","journal-title":"Clin. Exp. Dent. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1002\/cre2.402","article-title":"Initial investigations of a novel bioluminescence method for imaging dental demineralization","volume":"7","author":"Longbottom","year":"2021","journal-title":"Clin. Exp. Dent. Res."},{"key":"ref_16","first-page":"15","article-title":"Ability of quantitative light-induced fluorescence (QLF) to assess the activity of white spot lesions during dehydration","volume":"19","author":"Ando","year":"2006","journal-title":"Am. J. Dent."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1177\/00220345251356472","article-title":"Advanced Laboratory Assessments in Caries Mineralization Research: A Review","volume":"104","author":"Fu","year":"2025","journal-title":"J. Dent. Res."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Zandona, A.F., and Longbottom, C. (2019). Visusal Detection Criteria using the International Caries Detection and Assessment System (ICDAS). Detection and Assessment of Dental Caries, Springer.","DOI":"10.1007\/978-3-030-16967-1"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Zandona, A.F., and Longbottom, C. (2019). Nyvad Criteria for Assessment of Caries Lesion Activty. Detection and Assessment of Dental Caries, Springer.","DOI":"10.1007\/978-3-030-16967-1"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1159\/000224213","article-title":"Lesion activity assessment","volume":"21","author":"Ekstrand","year":"2009","journal-title":"Monogr. Oral Sci."},{"key":"ref_21","first-page":"100025","article-title":"Analysis of the transparent surface layer formed at the surfaces of arrested enamel caries lesions with tomographic imaging methods","volume":"2","author":"Chang","year":"2023","journal-title":"JADA Found. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1177\/0022034511429570","article-title":"An X-ray microtomographic study of natural white-spot enamel lesions","volume":"91","author":"Cochrane","year":"2012","journal-title":"J. Dent. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1159\/000533563","article-title":"Microcomputed Tomography Mineral Density Profile as Reference Standard for Early Carious Lesion Activity Assessment","volume":"57","author":"Hoxie","year":"2023","journal-title":"Caries Res."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Zandona, A.F., and Longbottom, C. (2019). Quantatative Light Induced Fluorescence. Detection and Assessment of Dental Caries, Springer.","DOI":"10.1007\/978-3-030-16967-1"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"39905","DOI":"10.1038\/s41598-025-23631-6","article-title":"Diagnostic accuracy of quantitative light-induced fluorescence in detecting caries of various types and locations: A systematic review and meta-analysis","volume":"15","author":"Lee","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"104368","DOI":"10.1016\/j.pdpdt.2024.104368","article-title":"Validity assessment of a third-generation light-induced fluorescence device in detecting proximal and occlusal caries lesions: A cross-sectional study","volume":"50","author":"Bittar","year":"2024","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"ref_27","first-page":"241","article-title":"Comparison of laser fluorescence and longitudinal microradiography for quantitative assessment of in vitro enamel caries","volume":"26","author":"Oliveby","year":"1992","journal-title":"Caries. Res."},{"key":"ref_28","first-page":"2","article-title":"A New Method for in vivo Quantification of Changes in Initial Enamel Caries with laser Fluorescence","volume":"29","author":"Sundstrom","year":"1995","journal-title":"Caries Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"106086","DOI":"10.1016\/j.jdent.2025.106086","article-title":"Application of quantitative light-induced fluorescence technology in early caries detection and resin infiltration treatment","volume":"162","author":"Shi","year":"2025","journal-title":"J. Dent."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1159\/000068229","article-title":"Influence of enamel thickness on quantification of mineral loss in enamel using laser-induced fluorescence","volume":"37","author":"Ando","year":"2003","journal-title":"Caries Res."},{"key":"ref_31","first-page":"132","article-title":"Laser fluorescence quantification of remineralisation in situ of incipient enamel lesions: Influence of fluoride supplements","volume":"31","author":"Oliveby","year":"1997","journal-title":"Caries Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1034\/j.1600-0722.2001.00997.x","article-title":"Application of quantitative light-induced fluorescence to monitor incipient lesions in caries-active children. A comparative study of remineralisation by fluoride varnish and professional cleaning","volume":"109","author":"Bjorkman","year":"2001","journal-title":"Eur. J. Oral. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"35005","DOI":"10.1117\/1.JBO.22.3.035005","article-title":"Pilot clinical study to assess caries lesion activity using quantitative light-induced fluorescence during dehydration","volume":"22","author":"Ando","year":"2017","journal-title":"J. Biomed. Opt."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1159\/000073919","article-title":"Effect of imaging geometry on evaluating natural white-spot lesions using quantitative light-induced fluorescence","volume":"38","author":"Ando","year":"2004","journal-title":"Caries Res."},{"key":"ref_35","first-page":"233","article-title":"Time-gated in vivo autofluorescence imaging of dental caries","volume":"45","author":"Konig","year":"1999","journal-title":"Cell. Mol. Biol."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Zandona, A.F., and Longbottom, C. (2019). DIAGNOdent. Detection and Assessment of Dental Caries, Springer.","DOI":"10.1007\/978-3-030-16967-1"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"017001","DOI":"10.1117\/1.JBO.26.1.019801","article-title":"Optical pH measurement system using a single fluorescent dye for assessing susceptibility to dental caries","volume":"26","author":"Sharma","year":"2021","journal-title":"J. Biomed. Opt."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1109\/TBME.2022.3153659","article-title":"O-pH: Optical pH Monitor to Measure Dental Biofilm Acidity and Assist in Enamel Health Monitoring","volume":"69","author":"Sharma","year":"2022","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1159\/000486139","article-title":"Diagnostic Accuracy of a Bioluminescence System for the Assessment of Caries Activity on Occlusal Surfaces","volume":"52","author":"Moos","year":"2018","journal-title":"Caries Res."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Zandona, A.F., and Longbottom, C. (2019). Bioluminescence Technology to Aid lesion Activity Assessment. Detection and Assessment of Dental Caries, Springer.","DOI":"10.1007\/978-3-030-16967-1_22"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Gomes, A.S., Zezell, D., Mota, C.B.O., and Girkin, J. (2024). Optical coherence tomography in dentistry. Scientific Developments to Clinical Applications, CRC Press.","DOI":"10.1201\/9781351104562"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.jdent.2015.03.005","article-title":"Assessment of remineralization via measurement of dehydration rates with thermal and near-IR reflectance imaging","volume":"43","author":"Lee","year":"2015","journal-title":"J. Dent."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"056006","DOI":"10.1117\/1.JBO.26.5.056006","article-title":"Dynamic SWIR Imaging near the 1950 nm water absorption band for caries lesion diagnosis","volume":"26","author":"Tressel","year":"2021","journal-title":"J. Biomed. Opt."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1002\/lsm.23677","article-title":"Monitoring lesion activity on primary teeth with CP-OCT and SWIR reflectance imaging","volume":"55","author":"Zhu","year":"2023","journal-title":"Lasers Surg. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.dental.2011.11.020","article-title":"Nondestructive monitoring of the repair of enamel artificial lesions by an acidic remineralization model using polarization-sensitive optical coherence tomography","volume":"28","author":"Kang","year":"2012","journal-title":"Dent. Mater."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/sj.bdj.4805177","article-title":"The histopathology of enamel caries in young and old permanent teeth","volume":"155","author":"Kidd","year":"1983","journal-title":"Br. Dent. J."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1159\/000539406","article-title":"Enamel Caries Lesion Depth Obtained by Optical Coherence Tomography and Transverse Microradiography: A Comparative Study","volume":"58","author":"Braga","year":"2024","journal-title":"Caries Res."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Hwang, I.K., Kim, S.Y., and Kim, T.I. (2025). Optical Coherence Tomography for Assessing the Severity of Dental Caries: An In Vitro Validation Study. Dent. J., 13.","DOI":"10.3390\/dj13110543"},{"key":"ref_49","first-page":"e1","article-title":"Optical coherence tomography and polarized light microscopy for the evaluation of artificial caries: A preliminary study","volume":"67","author":"Quitero","year":"2019","journal-title":"Gen. Dent."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.jdent.2010.05.004","article-title":"Validation of swept-source optical coherence tomography (SS-OCT) for the diagnosis of occlusal caries","volume":"38","author":"Shimada","year":"2010","journal-title":"J. Dent."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.jobcr.2021.09.006","article-title":"Cross-sectional visual comparison of remineralization efficacy of various agents on early smooth surface caries of primary teeth with swept source optical coherence tomography","volume":"11","author":"Thomas","year":"2021","journal-title":"J. Oral. Biol. Craniofacial Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"C35","DOI":"10.1177\/154405910408301s07","article-title":"What Constitutes Dental Caries? Histopathology of Carious Enamel and Dentin Related to the Action of Cariogenic Biofilms","volume":"83","author":"Kidd","year":"2004","journal-title":"J. Dent. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1002\/lsm.22500","article-title":"Clinical monitoring of smooth surface enamel lesions using CP-OCT during nonsurgical intervention","volume":"48","author":"Chan","year":"2016","journal-title":"Lasers Surg. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1117\/1.JBO.23.7.071203","article-title":"Detection of carious lesions utilizing depolarization imaging by polarization sensitive optical coherence tomography","volume":"23","author":"Golde","year":"2018","journal-title":"J. Biomed. Opt."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e202500422","DOI":"10.1002\/jbio.202500422","article-title":"Depolarization-Based Multimodal Optical Imaging of Carious Lesions","volume":"19","author":"Grundmann","year":"2026","journal-title":"J. Biophotonics"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Hund, S.M.M., Golde, J., Tetschke, F., Basche, S., Meier, M., Kirsten, L., Koch, E., Hannig, C., and Walther, J. (2024). Polarization-Sensitive Optical Coherence Tomography for Monitoring De- and Remineralization of Bovine Enamel In Vitro. Diagnostics, 14.","DOI":"10.3390\/diagnostics14040367"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1117\/1.JBO.23.7.071207","article-title":"In vivo imaging in the oral cavity by endoscopic optical coherence tomography","volume":"23","author":"Walther","year":"2018","journal-title":"J. Biomed. Opt."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"4247","DOI":"10.1364\/BOE.464707","article-title":"Local axis orientation mapped by polarization sensitive optical coherence tomography provides a unique contrast to identify caries lesions in enamel","volume":"13","author":"Tang","year":"2022","journal-title":"Biomed. Opt. Express"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Shi, B., Niu, J., Zhou, X., and Dong, X. (2022). Quantitative Assessment Methods of Early Enamel Caries with Optical Coherence Tomography: A Review. Appl. Sci., 12.","DOI":"10.3390\/app12178780"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"e202400031","DOI":"10.1002\/jbio.202400031","article-title":"Diagnosis of dental caries based on attenuation coefficients analysis of optical coherence tomography images","volume":"17","author":"Fan","year":"2024","journal-title":"J. Biophotonics"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1177\/0022034520951157","article-title":"Thermal Imaging of Root Caries In Vivo","volume":"99","author":"Yang","year":"2020","journal-title":"J. Dent. Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/jbio.201500333","article-title":"Activity assessment of root caries lesions with thermal and near-infrared imaging methods","volume":"10","author":"Lee","year":"2016","journal-title":"J. Biophotonics"},{"key":"ref_63","unstructured":"Kaneko, K., Matsuyama, K., and Nakashima, S. (1999, January 19\u201322). Quantification of Early Carious Enamel Lesions by using an Infrared Camera. Proceedings of the 4th Annual Indiana Conference, Indianapolis, IN, USA."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.jdent.2010.06.010","article-title":"Occlusal caries detection by using thermal imaging","volume":"38","author":"Zakian","year":"2010","journal-title":"J. Dent."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Ando, M., Sharp, N., and Adams, D. (2012). Pulse thermography for quantitative nondestructive evaluation of sound, de-mineralized and re-mineralized enamel. Health Monitoring of Structural and Biological Systems 2012, SPIE. Volume 8348.","DOI":"10.1117\/12.914371"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/0003-9969(93)90114-2","article-title":"Atomic-force microscopic study of dimensional changes in human dentine during drying","volume":"38","author":"Kinney","year":"1993","journal-title":"Arch. Oral. Biol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1177\/0810733","article-title":"Effect of perfusion with water on demineralization of human dentin in vitro","volume":"81","author":"Ozok","year":"2002","journal-title":"J. Dent. Res."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Zandona, A.F., and Longbottom, C. (2019). Photothermal Radiometry and Modulated Luminescence:The Canary System. Detection and Assessment of Dental Caries, Springer.","DOI":"10.1007\/978-3-030-16967-1"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"21798","DOI":"10.1038\/srep21798","article-title":"Noninvasive Assessment of Early Dental Lesion Using a Dual-Contrast Photoacoustic Tomography","volume":"6","author":"Cheng","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"107","DOI":"10.5624\/isd.20200259","article-title":"Photoacoustic imaging of occlusal incipient caries in the visible and near-infrared range","volume":"51","author":"Mota","year":"2021","journal-title":"Imaging Sci. Dent."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e13935","DOI":"10.1002\/acm2.13935","article-title":"Photoacoustic imaging of hidden dental caries using visible-light diode laser","volume":"24","author":"Tasmara","year":"2023","journal-title":"J. Appl. Clin. Med. Phys."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"e12257","DOI":"10.1111\/jicd.12257","article-title":"Remineralization of natural early caries lesions in vitro by P(11) -4 monitored with photothermal radiometry and luminescence","volume":"8","author":"Silvertown","year":"2017","journal-title":"J. Investig. Clin. Dent."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/s00784-015-1559-4","article-title":"In vivo validation of near-infrared light transillumination for interproximal dentin caries detection","volume":"20","author":"Kuhnisch","year":"2015","journal-title":"Clin. Oral. Investig."},{"key":"ref_74","first-page":"531","article-title":"Caries detection and diagnostics with near-infrared light transillumination: Clinical experiences","volume":"45","author":"Sochtig","year":"2014","journal-title":"Quintessence Int."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"e202100145","DOI":"10.1002\/jbio.202100145","article-title":"High contrast imaging of dental fluorosis in the short wavelength infrared (SWIR)","volume":"14","author":"Kashirtsev","year":"2021","journal-title":"J. Biophotonics"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s10103-024-04168-y","article-title":"In vitro Assessment of lesion activity using simultaneous time-resolved reflectance imaging at 1300 and 1950 nm","volume":"39","author":"Wycoff","year":"2024","journal-title":"Lasers Med. Sci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"105769","DOI":"10.1016\/j.jdent.2025.105769","article-title":"Assessment of the activity of root caries lesions using short wavelength infrared imaging\u2014An in vitro pilot study","volume":"157","author":"Wycoff","year":"2025","journal-title":"J. Dent."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1016\/j.dental.2020.10.005","article-title":"Raman spectroscopy for early detection and monitoring of dentin demineralization","volume":"36","author":"Marin","year":"2020","journal-title":"Dent. Mater."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1039\/C8AN01494A","article-title":"Assessment of the Raman spectroscopy effectiveness in determining the early changes in human enamel caused by artificial caries","volume":"144","author":"Buchwald","year":"2019","journal-title":"Analyst"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1039\/D0AN01938K","article-title":"Mineralization of dental tissues and caries lesions detailed with Raman microspectroscopic imaging","volume":"146","author":"Killenberger","year":"2021","journal-title":"Analyst"},{"key":"ref_81","first-page":"167","article-title":"Detection and Characterization of Human Teeth Caries Using 2D Correlation Raman Spectroscopy","volume":"9","year":"2019","journal-title":"J. Biomed. Phys. Eng."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Miyamoto, N., Adachi, T., Boschetto, F., Zanocco, M., Yamamoto, T., Marin, E., Somekawa, S., Ashida, R., Zhu, W., and Kanamura, N. (2020). Molecular Fingerprint Imaging to Identify Dental Caries Using Raman Spectroscopy. Materials, 13.","DOI":"10.3390\/ma13214900"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"122718","DOI":"10.1016\/j.talanta.2021.122718","article-title":"Surface analysis of dental caries using a wireless pH sensor and Raman spectroscopy for chairside diagnosis","volume":"235","author":"Tabata","year":"2021","journal-title":"Talanta"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"6009","DOI":"10.1364\/BOE.9.006009","article-title":"Full-scale Raman imaging for dental caries detection","volume":"9","author":"Yakubu","year":"2018","journal-title":"Biomed. Opt. Express"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"6379","DOI":"10.1039\/D1AN00954K","article-title":"Translational biophotonics with Raman imaging: Clinical applications and beyond","volume":"146","author":"Pence","year":"2021","journal-title":"Analyst"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"6274","DOI":"10.1364\/OE.16.006274","article-title":"Early dental caries detection using a fibre-optic coupled polarization-resolved Raman spectroscopic system","volume":"16","author":"Ko","year":"2008","journal-title":"Opt. Express"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1364\/BOE.7.001284","article-title":"Optical diagnosis and characterization of dental caries with polarization-resolved hyperspectral stimulated Raman scattering microscopy","volume":"7","author":"Wang","year":"2016","journal-title":"Biomed. Opt. Express"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1007\/s10103-014-1638-9","article-title":"Early detection of dental fluorosis using Raman spectroscopy and principal component analysis","volume":"30","year":"2015","journal-title":"Lasers Med. Sci."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"20891","DOI":"10.1038\/s41598-020-78078-8","article-title":"Development of a new approach to diagnosis of the early fluorosis forms by means of FTIR and Raman microspectroscopy","volume":"10","author":"Seredin","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"93","DOI":"10.2334\/josnusd.54.93","article-title":"Analysis of the molecular structure of human enamel with fluorosis using micro-Raman spectroscopy","volume":"54","author":"Terrones","year":"2012","journal-title":"J. Oral. Sci."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Zepeda-Zepeda, M.A., Picquart, M., Irigoyen-Camacho, M.E., and Mejia-Gozalez, A.M. (2021). Diagnosis of Dental Fluorosis Using Micro-Raman Spectroscopy Applying a Principal Component-Linear Discriminant Analysis. Int. J. Environ. Res. Public. Health, 18.","DOI":"10.3390\/ijerph182010572"},{"key":"ref_92","unstructured":"Gregory, C., Hilton, A., Violette, K., and Klem, E.J.D. (2026, May 06). Colloidal Quantum Dot Photodetectors for Large Format NIR, SWIR, and eSWIR Imaging Arrays. Available online: https:\/\/www.swirvisionsystems.com\/wp-content\/uploads\/2023\/10\/Paper-66.3-CQD-PD-for-Large-Format-Sensors.pdf."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1093\/dmfr\/twaf053","article-title":"Machine learning algorithms enhance the accuracy of radiographic diagnosis of dental caries: A comparative study","volume":"54","author":"Hegde","year":"2025","journal-title":"Dentomaxillofac Radiol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"100827","DOI":"10.1016\/j.identj.2025.04.007","article-title":"AI-Driven Dental Caries Management Strategies: From Clinical Practice to Professional Education and Public Self Care","volume":"75","author":"Liang","year":"2025","journal-title":"Int. Dent. J."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1159\/000524167","article-title":"Machine Learning in the Diagnosis and Prognostic Prediction of Dental Caries: A Systematic Review","volume":"56","author":"Reyes","year":"2022","journal-title":"Caries Res."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"5032435","DOI":"10.1155\/2022\/5032435","article-title":"Uses of Different Machine Learning Algorithms for Diagnosis of Dental Caries","volume":"2022","author":"Talpur","year":"2022","journal-title":"J. Healthc. Eng."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"103217","DOI":"10.1016\/j.pdpdt.2022.103217","article-title":"Machine learning-based automatic identification and diagnosis of dental caries and calculus using hyperspectral fluorescence imaging","volume":"41","author":"Wang","year":"2023","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1177\/0022034519871884","article-title":"Caries Detection with Near-Infrared Transillumination Using Deep Learning","volume":"98","author":"Casalegno","year":"2019","journal-title":"J. Dent. Res."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"20210010","DOI":"10.1259\/dmfr.20210010","article-title":"Radiographic modalities for diagnosis of caries in a historical perspective: From film to machine-intelligence supported systems","volume":"50","author":"Wenzel","year":"2021","journal-title":"Dentomaxillofac Radiol."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/12\/1908\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:54:59Z","timestamp":1781880899000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/12\/1908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,19]]},"references-count":99,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["diagnostics16121908"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics16121908","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,19]]}}}