{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:37:31Z","timestamp":1785411451102,"version":"3.56.0"},"reference-count":35,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Economic Affairs, Industry, Climate Action, and Energy of the State of North Rhine\u2013Westphalia","award":["SIM-1-1"],"award-info":[{"award-number":["SIM-1-1"]}]},{"DOI":"10.13039\/501100008131","name":"University of Bonn","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008131","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/041nas322","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: Robotic-assisted bronchoscopy has emerged as an advanced technique for the evaluation of peripheral pulmonary lesions, offering improved navigation and targeting accuracy. While several studies investigating other diagnostic modalities have identified factors associated with higher diagnostic yield, such determinants remain poorly defined for shape-sensing robotic-assisted bronchoscopy (ssRAB). This study therefore aimed to identify predictors of diagnostic yield in robotic bronchoscopy. Methods: This retrospective single-center study included all consecutive patients who underwent ssRAB (IONTM system, Intuitive Surgical, Sunnyvale, CA, USA) between August 2024 and March 2026. Lung nodules undergoing marker placement only or procedures performed without cone-beam CT (CBCT) guidance were excluded. Collected variables included demographic characteristics, lesion size, lesion density (solid, part-solid, ground-glass), biopsy modality, and number of biopsy samples obtained. Diagnostic yield was defined as a definitive pathological diagnosis of the target lesion. Predictors of diagnostic success were assessed using univariable logistic regression. Results: In total, 111 pulmonary nodules were included in the analysis. The overall diagnostic yield was 88.3% (98\/111). The mean patient age was 64.94 \u00b1 7.9 years, with a predominance of female patients (58.4%). No significant associations were observed between diagnostic yield and lesion size (odds ratio [OR] 1.014 per mm; p = 0.764), lesion density (p = 0.892), or biopsy instrument (p = 0.835). However, an increased number of biopsy samples showed a positive association with diagnostic yield, showing a statistical trend (OR 1.22 per additional sample; p = 0.084). Conclusions: Robotic-assisted bronchoscopy provides a high diagnostic yield for peripheral pulmonary lesions. The number of biopsy samples appears to be the most relevant modifiable factor influencing diagnostic success, underscoring the importance of adequate tissue acquisition. In contrast, lesion characteristics and biopsy modality did not significantly affect outcomes in this cohort.<\/jats:p>","DOI":"10.3390\/diagnostics16131954","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T17:11:49Z","timestamp":1782234709000},"page":"1954","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predictors of Diagnostic Yield in Shape-Sensing Robotic-Assisted Bronchoscopy (ssRAB): A Retrospective Single-Center Study"],"prefix":"10.3390","volume":"16","author":[{"given":"Hruy","family":"Menghesha","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, University Hospital Bonn, University of Bonn, 53127 Bonn, Germany"},{"name":"Department of Thoracic Surgery, Helios Clinic Bonn\/Rhein-Sieg, 53123 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0705-2973","authenticated-orcid":false,"given":"Jan","family":"Arensmeyer","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, University Hospital Bonn, University of Bonn, 53127 Bonn, Germany"},{"name":"Bonn Surgical Technology Center (BOSTER), University Hospital Bonn, Joseph-Schumpeter-Allee 1, 53227 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3940-0501","authenticated-orcid":false,"given":"Philipp","family":"Feodorovici","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, University Hospital Bonn, University of Bonn, 53127 Bonn, Germany"},{"name":"Bonn Surgical Technology Center (BOSTER), University Hospital Bonn, Joseph-Schumpeter-Allee 1, 53227 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7930-0270","authenticated-orcid":false,"given":"Mark","family":"Coburn","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, University of Bonn, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Skowasch","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II\u2014Pneumology\/Cardiology, University Hospital Bonn, University of Bonn, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2835-8560","authenticated-orcid":false,"given":"Tatjana","family":"Dell","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital Bonn, University of Bonn, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7715-4636","authenticated-orcid":false,"given":"Julian","family":"Luetkens","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital Bonn, University of Bonn, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, University Hospital Bonn, University of Bonn, 53127 Bonn, Germany"},{"name":"Department of Thoracic Surgery, Helios Clinic Bonn\/Rhein-Sieg, 53123 Bonn, Germany"},{"name":"Bonn Surgical Technology Center (BOSTER), University Hospital Bonn, Joseph-Schumpeter-Allee 1, 53227 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4831-0908","authenticated-orcid":false,"given":"Donatas","family":"Zalepugas","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, University Hospital Bonn, University of Bonn, 53127 Bonn, Germany"},{"name":"Department of Thoracic Surgery, Helios Clinic Bonn\/Rhein-Sieg, 53123 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"National Lung Screening Trial Research Team (2011). 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