{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:16:30Z","timestamp":1793132190816,"version":"4.5.0"},"reference-count":63,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Oradea"},{"id":[{"id":"https:\/\/ror.org\/00wzhv093","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: Inflammation plays a central role in the pathophysiology of ST-elevation myocardial infarction (STEMI) and may influence myocardial injury, ventricular dysfunction and clinical outcomes. Simple inflammatory biomarkers derived from routine laboratory tests have been proposed as potential prognostic indicators in patients undergoing primary percutaneous coronary intervention (PCI). Objective: This study aimed to evaluate the association between admission inflammatory biomarkers, echocardiographic markers of ventricular dysfunction and in-hospital mortality in patients with STEMI treated with primary PCI. Methods: We conducted a retrospective observational study including 600 consecutive patients admitted with STEMI and treated with primary PCI between January 2021 and August 2025. Inflammatory biomarkers measured at admission included C-reactive protein (CRP); neutrophil-to-lymphocyte ratio (NLR); platelet-to-lymphocyte ratio (PLR); systemic immune-inflammation index (SII) and C-reactive protein-to-lymphocyte ratio (CLR). Echocardiographic parameters and clinical outcomes were recorded. Multivariable logistic regression analysis was performed to identify independent predictors of in-hospital mortality. Results: In-hospital mortality occurred in 54 patients (9.0%). Patients with reduced left ventricular ejection fraction (LVEF \u2264 40%) had significantly higher CRP and CLR levels (p &lt; 0.01). Inflammatory biomarkers were associated with markers of ventricular dysfunction but were not independent predictors of mortality. Age, LVEF &lt; 40% and the number of residual coronary lesions independently predicted in-hospital death. Conclusions: In STEMI patients undergoing primary PCI, early mortality is mainly determined by age; ventricular dysfunction and residual coronary disease burden, while inflammatory biomarkers primarily reflect the severity of myocardial injury rather than independently predicting short-term mortality.<\/jats:p>","DOI":"10.3390\/diagnostics16131978","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T12:37:55Z","timestamp":1782391075000},"page":"1978","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Early Inflammatory Biomarkers, Ventricular Dysfunction and In-Hospital Mortality in Patients with ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4883-3856","authenticated-orcid":false,"given":"Dan Claudiu","family":"Magureanu","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Toxicology and Clinical Pharmacology, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"},{"name":"Cardiology Department, Niculae Stancioiu Heart Institute, 400001 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luiza","family":"Hiceag","sequence":"additional","affiliation":[{"name":"Cardiology Department, Rehabilitation Hospital, 400347 Cluj-Napoca, Romania"},{"name":"Cardiology Department, Municipal Hospital Aiud, 515200 Aiud, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9229-2656","authenticated-orcid":false,"given":"Camelia Bianca","family":"Rus","sequence":"additional","affiliation":[{"name":"Department of Medical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania"},{"name":"Clinical County Emergency Hospital Bihor, 410169 Oradea, Romania"},{"name":"Doctoral School of Biological and Biomedical Sciences, University of Oradea, 410087 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8981-1958","authenticated-orcid":false,"given":"Timea Claudia","family":"Ghitea","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0855-938X","authenticated-orcid":false,"given":"Corina","family":"Cinezan","sequence":"additional","affiliation":[{"name":"Department of Medical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania"},{"name":"Clinical County Emergency Hospital Bihor, 410169 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"14514","DOI":"10.1038\/s41598-025-98408-y","article-title":"The effect of inflammatory markers on mortality in patients with acute myocardial infarction","volume":"15","author":"Yang","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"104409","DOI":"10.1016\/j.numecd.2025.104409","article-title":"The role of inflammation in acute coronary syndrome: A systematic review on biochemical inflammatory assessment and anti-inflammatory therapies","volume":"36","author":"Intravaia","year":"2026","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3041565","DOI":"10.1155\/2017\/3041565","article-title":"The role of hematological indices in patients with acute coronary syndrome","volume":"2017","author":"Budzianowski","year":"2017","journal-title":"Dis. Markers"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Sun, T., Chen, P., and Zheng, X. (2025). A retrospective analysis from NHANES 2003\u20132018 on the associations between inflammatory markers and coronary artery disease, all-cause mortality and cardiovascular mortality. PLoS ONE, 20.","DOI":"10.1371\/journal.pone.0326953"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"03000605251381579","DOI":"10.1177\/03000605251381579","article-title":"Association between the C-reactive protein\u2013albumin\u2013lymphocyte index and severity of acute coronary syndrome: A retrospective study","volume":"53","author":"Wu","year":"2025","journal-title":"J. Int. Med. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.sjbs.2016.10.015","article-title":"The utility of inflammation and platelet biomarkers in patients with acute coronary syndromes","volume":"25","author":"Koper","year":"2018","journal-title":"Saudi J. Biol. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Monteiro J\u00fanior, J.G., de Torres, D., da Silva, M.C., Martins, C.M., da Silva, I.K., do Nascimento, M.E., dos Santos, A.C., Montarroyos, U.R., and Filho, D.C. (2018). Prognostic value of hematological parameters in patients with acute myocardial infarction: Intrahospital outcomes. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0194897"},{"key":"ref_8","first-page":"1177","article-title":"Higher Neutrophil\/lymphocyte ratio is related to lower ejection fraction and higher long-term all-cause mortality in ST-elevation myocardial infarction patients","volume":"30","author":"Arbel","year":"2014","journal-title":"Can. J. Cardiol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Mahdavi-Roshan, M., Ghorbani, Z., Gholipour, M., Salari, A., Savar Rakhsh, A., and Kheirkhah, J. (2022). Evaluation of cardiometabolic risk markers linked to reduced left ventricular ejection fraction (LVEF) in patients with ST-elevation myocardial infarction (STEMI). BMC Cardiovasc. Disord., 22.","DOI":"10.1186\/s12872-022-02660-3"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e38692","DOI":"10.1097\/MD.0000000000038692","article-title":"Neutrophil to lymphocyte ratio as a prognostic marker for cardiovascular outcomes in patients with st-segment elevation myocardial infarction after percutaneous coronary intervention: A systematic review and meta analysis","volume":"103","author":"Kumar","year":"2024","journal-title":"Medicine"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1016\/j.jacc.2016.01.073","article-title":"Inflammation as a driver of adverse left ventricular remodeling after acute myocardial infarction","volume":"67","author":"Westman","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_12","first-page":"2361","article-title":"Inflammatory markers and contrast-induced nephropathy risk: A meta-analysis of NLR and PLR in ACS patients undergoing percutaneous coronary intervention","volume":"106","author":"AlHammouri","year":"2025","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1177\/00033197231185445","article-title":"Association between inflammatory biomarkers and contrast-induced acute kidney injury in ACS patients undergoing percutaneous coronary intervention: A cross-sectional study","volume":"75","author":"Yang","year":"2023","journal-title":"Angiology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1002\/clc.22722","article-title":"Predictive value of inflammatory factors on contrast-induced acute kidney injury in patients who underwent an emergency percutaneous coronary intervention","volume":"40","author":"Yuan","year":"2017","journal-title":"Clin. Cardiol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Blasco, A., Rosell, A., Castej\u00f3n, R., Royuela, A., Th\u00e5lin, C., Ramil, E., Elorza, S., Coronado, M.-J., Mart\u00edn, P., and V\u00e1zquez, J. (2025). Inflammatory and neutrophil extracellular trap markers to predict cardiac events after st-segment elevation myocardial infarction. PLoS ONE, 20.","DOI":"10.1371\/journal.pone.0319759"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1186\/s40001-025-03493-4","article-title":"The prognostic values of the SII and the Siri in patients with STEMI following percutaneous coronary intervention: A retrospective study","volume":"30","author":"Yan","year":"2025","journal-title":"Eur. J. Med. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/MCA.0000000000001117","article-title":"Systemic immune-inflammation index predicts in-hospital and long-term outcomes in patients with st-segment elevation myocardial infarction","volume":"33","author":"Keskin","year":"2022","journal-title":"Coron. Artery Dis."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Takagi, K., Tanaka, A., Yoshioka, N., Morita, Y., Yoshida, R., Kanzaki, Y., Watanabe, N., Yamauchi, R., Komeyama, S., and Sugiyama, H. (2021). In-hospital mortality among consecutive patients with ST-elevation myocardial infarction in modern primary percutaneous intervention era~ insights from 15-year data of single-center hospital-based registry~. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0252503"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"10072","DOI":"10.1038\/s41598-019-46486-0","article-title":"Independent predictors of cardiac mortality and hospitalization for heart failure in a multi-ethnic Asian st-segment elevation myocardial infarction population treated by primary percutaneous coronary intervention","volume":"9","author":"Bulluck","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jacc.2021.04.067","article-title":"Predicting in-hospital mortality in patients undergoing percutaneous coronary intervention","volume":"78","author":"Wang","year":"2021","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"101647","DOI":"10.1016\/j.jacadv.2025.101647","article-title":"Association of intramyocardial hemorrhage with inflammatory biomarkers in patients with st-segment elevation myocardial infarction","volume":"4","author":"Tiller","year":"2025","journal-title":"JACC Adv."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Bochaton, T., Lassus, J., Paccalet, A., Derimay, F., Rioufol, G., Prieur, C., Bonnefoy-Cudraz, E., Crola Da Silva, C., Bernelin, H., and Amaz, C. (2021). Association of myocardial hemorrhage and persistent microvascular obstruction with circulating inflammatory biomarkers in STEMI patients. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0245684"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e494","DOI":"10.1161\/CIR.0000000000001387","article-title":"Coronary artery revascularization in the older adult population: A scientific statement from the American Heart Association","volume":"152","author":"Damluji","year":"2025","journal-title":"Circulation"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1016\/j.amjcard.2015.09.022","article-title":"Comparison of outcomes of patients with st-segment elevation myocardial infarction treated by primary percutaneous coronary intervention analyzed by age groups (<75, 75 to 85 and >85 years); (results from the Bremen STEMI Registry)","volume":"116","author":"Fach","year":"2015","journal-title":"Am. J. Cardiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"E32","DOI":"10.1161\/CIR.0000000000001112","article-title":"Management of acute coronary syndrome in the older adult population: A scientific statement from the American Heart Association","volume":"147","author":"Damluji","year":"2023","journal-title":"Circulation"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1016\/j.amjcard.2017.03.014","article-title":"Comparison of 30-day and long-term outcomes and hospital complications among patients aged <75 versus \u226575 years with ST-elevation myocardial infarction undergoing percutaneous coronary intervention","volume":"119","author":"Topaz","year":"2017","journal-title":"Am. J. Cardiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.amjmed.2019.07.044","article-title":"Fifteen-year trends of cardiogenic shock and mortality in patients with diabetes and acute coronary syndromes","volume":"133","author":"Dauriz","year":"2020","journal-title":"Am. J. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/5584_2020_481","article-title":"Diabetes mellitus and acute myocardial infarction: Impact on short and long-term mortality","volume":"1307","author":"Milazzo","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e028923","DOI":"10.1161\/JAHA.122.028923","article-title":"Impact of diabetes on outcomes in patients hospitalized with acute myocardial infarction: Insights from the atherosclerosis risk in communities study community surveillance","volume":"12","author":"Jain","year":"2023","journal-title":"J. Am. Heart Assoc."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Chen, S., Huang, Z., Chen, L., Zhao, X., Kang, Y., Lai, W., Lu, X., Zhou, Y., He, Y., and Huang, H. (2021). Does diabetes mellitus increase the short- and long-term mortality in patients with critical acute myocardial infarction? Results from American mimic-III and Chinese CIN cohorts. Front. Endocrinol., 12.","DOI":"10.3389\/fendo.2021.797049"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.jacc.2018.06.036","article-title":"Prevention and treatment of tobacco use","volume":"72","author":"Kalkhoran","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1053\/euhj.1998.1086","article-title":"Smoking, lipoproteins and coronary heart disease risk data from the M\u00fcnster Heart Study (PROCAM)","volume":"19","author":"Cullen","year":"1998","journal-title":"Eur. Heart J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1016\/j.jacc.2003.12.047","article-title":"The pathophysiology of cigarette smoking and cardiovascular disease","volume":"43","author":"Ambrose","year":"2004","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.jacc.2021.12.016","article-title":"Managing atherosclerotic cardiovascular risk in young adults","volume":"79","author":"Stone","year":"2022","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1001\/jama.2022.20149","article-title":"Treatment time and in-hospital mortality among patients with st-segment elevation myocardial infarction, 2018\u20132021","volume":"328","author":"Jollis","year":"2022","journal-title":"JAMA"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e012188","DOI":"10.1161\/JAHA.119.012188","article-title":"Prognostic implications of Door-to-balloon time and onset-to-door time on mortality in patients with st-segment\u2013elevation myocardial infarction treated with primary percutaneous coronary intervention","volume":"8","author":"Park","year":"2019","journal-title":"J. Am. Heart Assoc."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1136\/heartjnl-2017-312517","article-title":"Coronary intervention door-to-balloon time and outcomes in ST-elevation myocardial infarction: A meta-analysis","volume":"104","author":"Foo","year":"2018","journal-title":"Heart"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/S0140-6736(14)61932-2","article-title":"Relation between door-to-balloon times and mortality after primary percutaneous coronary intervention over time: A retrospective study","volume":"385","author":"Nallamothu","year":"2015","journal-title":"Lancet"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"107284","DOI":"10.1016\/j.ahj.2025.107284","article-title":"Complete revascularization in patients with acute myocardial infarction and multivessel disease: Pooled analysis of Kaplan-Meier-derived individual-patient-data","volume":"292","author":"Abdelaziz","year":"2026","journal-title":"Am. Heart J."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/S0140-6736(21)02391-6","article-title":"Acute coronary syndromes","volume":"399","author":"Bergmark","year":"2022","journal-title":"Lancet"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1056\/NEJMoa2307823","article-title":"Timing of complete revascularization with Multivessel PCI for myocardial infarction","volume":"389","author":"Varbella","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.amjcard.2020.08.030","article-title":"Meta-analysis of complete versus culprit-only revascularization in patients with st-segment elevation myocardial infarction and Multivessel coronary disease","volume":"135","author":"Levett","year":"2020","journal-title":"Am. J. Cardiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ahj.2018.07.017","article-title":"The impact of incomplete revascularization on early and late outcomes in ST-elevation myocardial infarction","volume":"205","author":"Burgess","year":"2018","journal-title":"Am. Heart J."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1016\/j.jacc.2024.11.009","article-title":"2025 ACC\/AHA\/ACEP\/NAEMSP\/SCAI guideline for the management of patients with acute coronary syndromes","volume":"85","author":"Rao","year":"2025","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jacc.2025.05.013","article-title":"10-year outcome of complete or infarct artery-only revascularization in stemi with multivessel disease","volume":"86","author":"Marquard","year":"2025","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Banai, A., Levit, D., Morgan, S., Loewenstein, I., Merdler, I., Hochstadt, A., Szekely, Y., Topilsky, Y., Banai, S., and Shacham, Y. (2022). Association between C-reactive protein velocity and left ventricular function in patients with st-elevated myocardial infarction. J. Clin. Med., 11.","DOI":"10.3390\/jcm11020401"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s12944-022-01672-4","article-title":"Peri-event plasma PCSK9 and HSCRP after an acute myocardial infarction correlate with early deterioration of left ventricular ejection fraction: A cohort study","volume":"21","author":"Palacio","year":"2022","journal-title":"Lipids Health Dis."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ijcard.2022.10.142","article-title":"Features of metabolic syndrome and inflammation independently affect left ventricular function early after first myocardial infarction","volume":"370","author":"Traub","year":"2023","journal-title":"Int. J. Cardiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.amjcard.2009.11.025","article-title":"Left ventricular function and C-reactive protein levels in acute myocardial infarction","volume":"105","author":"Bursi","year":"2010","journal-title":"Am. J. Cardiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12933-024-02129-x","article-title":"Prognostic implications of systemic immune-inflammation index in myocardial infarction patients with and without diabetes: Insights from the NOAFCAMI-SH registry","volume":"23","author":"Luo","year":"2024","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Du, Y., Deng, X., Song, Y., and Yan, J. (2025). Prognostic value of the systemic immune-inflammation index in patients with acute myocardial infarction: A systematic review and meta-analysis. Angiology, 00033197251392661.","DOI":"10.1177\/00033197251392661"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e32215","DOI":"10.1097\/MD.0000000000032215","article-title":"The relation between apical thrombus formation and systemic immune-inflammation index in patients with acute anterior myocardial infarction","volume":"101","author":"Tok","year":"2022","journal-title":"Medicine"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1007\/s10554-024-03064-4","article-title":"Systemic immune- inflammation index predicts post-mi left ventricular remodeling","volume":"40","author":"Kurklu","year":"2024","journal-title":"Int. J. Cardiovasc. Imaging"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Mester, A., Rat, N., Benedek, T., Opincariu, D., Hodas, R., Chitu, M., and Benedek, I. (2022). Acute-phase inflammatory reaction predicts CMR myocardial scar pattern and 2-year mortality in STEMI patients undergoing primary PCI. J. Clin. Med., 11.","DOI":"10.3390\/jcm11051222"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.ijcard.2020.12.006","article-title":"High sensitivity C-reactive protein is associated with worse infarct healing after revascularized ST-elevation myocardial infarction","volume":"328","author":"Tiller","year":"2021","journal-title":"Int. J. Cardiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/S0140-6736(25)01394-7","article-title":"Prevention of heart failure after acute myocardial infarction","volume":"406","author":"Udell","year":"2025","journal-title":"Lancet"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ijcard.2017.04.054","article-title":"Prognostic impact of residual SYNTAX score in patients with ST-elevation myocardial infarction and multivessel disease: Analysis of an 8-year all-comers registry","volume":"243","author":"Braga","year":"2017","journal-title":"Int. J. Cardiol."},{"key":"ref_58","first-page":"740","article-title":"Prognostic impact of the residual SYNTAX score on in-hospital outcomes in patients undergoing primary percutaneous coronary intervention","volume":"88","author":"Khan","year":"2016","journal-title":"Catheter Cardiovasc Interv."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1097\/MCA.0000000000001074","article-title":"Residual SYNTAX II score and long-term outcomes post-ST-elevation myocardial infarction in an urban US cohort: The Montefiore STEMI registry","volume":"33","author":"Bortnick","year":"2022","journal-title":"Coron. Artery Dis."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1016\/j.ijcard.2013.01.004","article-title":"Prognostic relevance of baseline pro- and anti-inflammatory markers in STEMI: An APEX AMI substudy","volume":"168","author":"Newby","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.jacc.2016.05.049","article-title":"Predicting in-hospital mortality in patients with acute myocardial infarction","volume":"68","author":"McNamara","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1055\/s-0039-1695007","article-title":"Relationship of platelet reactivity and inflammatory markers to recurrent adverse events in patients with ST-elevation myocardial infarction","volume":"119","author":"Adatia","year":"2019","journal-title":"Thromb. Haemost."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"e096621","DOI":"10.1136\/bmjopen-2024-096621","article-title":"Predictive value of novel inflammatory markers combined with GRACE score for in-hospital outcome in patients with ST-segment elevation myocardial infarction: A retrospective observational study","volume":"15","author":"Xin","year":"2025","journal-title":"BMJ Open."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/13\/1978\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T13:14:08Z","timestamp":1782393248000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/13\/1978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,25]]},"references-count":63,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["diagnostics16131978"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics16131978","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,25]]}}}