{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:18:54Z","timestamp":1785417534781,"version":"3.56.0"},"reference-count":25,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Noncommunicable Chronic Diseases-National Science and Technology Major Project","award":["2025ZD0548504"],"award-info":[{"award-number":["2025ZD0548504"]}]},{"name":"Tianjin Health Research Project","award":["TJWJ2023QN064"],"award-info":[{"award-number":["TJWJ2023QN064"]}]},{"award":["TJWJ2023QN064"],"award-info":[{"award-number":["TJWJ2023QN064"]}],"id":[{"id":"https:\/\/ror.org\/059qgvg50","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Tianjin Key Medical Discipline Construction Project","award":["TJYXZDXK-3-031C"],"award-info":[{"award-number":["TJYXZDXK-3-031C"]}]},{"name":"Tianjin Key Medical Discipline Construction Project","award":["TJYXZDXK-3-006A"],"award-info":[{"award-number":["TJYXZDXK-3-006A"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: The aim of this study was to evaluate the performance of the Node-RADS scoring system for predicting lymph node metastasis in patients with non-small cell lung cancer (NSCLC) after neoadjuvant therapy and to assess its prognostic value for overall survival (OS) and event-free survival (EFS). Methods: A total of 247 patients with non-small cell lung cancer (NSCLC) from three centers who underwent surgery after neoadjuvant therapy were retrospectively enrolled. Post-treatment Node-RADS scores were reassessed by radiologists based on preoperative contrast-enhanced CT images. Logistic regression analysis was used to evaluate the predictive value of Node-RADS for postoperative pathological lymph node metastasis, while Cox regression analysis was performed to assess its associations with OS and EFS. Kaplan\u2013Meier analysis was used to compare survival differences among different Node-RADS risk groups. Results: A total of 247 patients were included in this study, comprising 211 men and 36 women, with a mean age of 63.40 \u00b1 7.58 years. Post-treatment Node-RADS score was significantly associated with both OS and EFS. In multivariable Cox regression analysis, Node-RADS remained independently associated with OS (HR = 1.79, 95% CI: 1.50\u20132.15, p &lt; 0.001) and EFS (HR = 1.41, 95% CI: 1.23\u20131.62, p &lt; 0.001). Using a Node-RADS score of 3 as the cutoff value, patients in the high-risk group had significantly worse OS and EFS than those in the low-risk group (both p &lt; 0.01). For the prediction of lymph node metastasis, the inclusion of post-treatment Node-RADS markedly improved the discriminatory performance of the model, with an AUC of 0.769, a sensitivity of 46.2%, and a specificity of 87.6%. Conclusions: The Node-RADS score may provide useful imaging information for patient-level assessment of residual lymph node metastasis risk and survival stratification in patients with NSCLC after neoadjuvant therapy. These findings suggest that the scoring system may support patient-level post-treatment risk assessment.<\/jats:p>","DOI":"10.3390\/diagnostics16132021","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T05:49:33Z","timestamp":1782712173000},"page":"2021","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic and Diagnostic Value of Node-RADS for Non-Small Cell Lung Cancer Following Neoadjuvant Therapy: A Multicenter Cohort Study"],"prefix":"10.3390","volume":"16","author":[{"given":"Jianyu","family":"Wang","sequence":"first","affiliation":[{"name":"Graduate School, Tianjin Medical University, Tianjin 300070, China"},{"name":"Thoracic Surgery Clinical College, Tianjin Medical University, Tianjin 300070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Tianjin Chest Hospital, Tianjin 300222, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Beijing Chest Hospital, Beijing 101149, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8277-0546","authenticated-orcid":false,"given":"Han","family":"Zhang","sequence":"additional","affiliation":[{"name":"Graduate School, Tianjin University, Tianjin 300072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojiang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Graduate School, Tianjin University, Tianjin 300072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuqiao","family":"Mu","sequence":"additional","affiliation":[{"name":"Graduate School, Tianjin Medical University, Tianjin 300070, China"},{"name":"Thoracic Surgery Clinical College, Tianjin Medical University, Tianjin 300070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Graduate School, Tianjin University, Tianjin 300072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanbo","family":"Wang","sequence":"additional","affiliation":[{"name":"Graduate School, Tianjin Medical University, Tianjin 300070, China"},{"name":"Thoracic Surgery Clinical College, Tianjin Medical University, Tianjin 300070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenchun","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Imaging, Tianjin Chest Hospital, Tianjin 300222, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an 710061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0669-0359","authenticated-orcid":false,"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Tianjin Chest Hospital, Tianjin 300222, China"},{"name":"Graduate School, Tianjin University, Tianjin 300072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2222-4657","authenticated-orcid":false,"given":"Daqiang","family":"Sun","sequence":"additional","affiliation":[{"name":"Graduate School, Tianjin Medical University, Tianjin 300070, China"},{"name":"Thoracic Surgery Clinical College, Tianjin Medical University, Tianjin 300070, China"},{"name":"Department of Thoracic Surgery, Tianjin Chest Hospital, Tianjin 300222, China"},{"name":"Graduate School, Tianjin University, Tianjin 300072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"ref_1","first-page":"7","article-title":"Cancer statistics, 2022","volume":"72","author":"Siegel","year":"2022","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1016\/j.jtho.2015.09.009","article-title":"The IASLC Lung Cancer Staging Project: Proposals for Revision of the TNM Stage Groupings in the Forthcoming (Eighth) Edition of the TNM Classification for Lung Cancer","volume":"11","author":"Goldstraw","year":"2016","journal-title":"J. Thorac. Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1056\/NEJMoa2302983","article-title":"Perioperative Pembrolizumab for Early-Stage Non-Small-Cell Lung Cancer","volume":"389","author":"Wakelee","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/s41591-023-02660-6","article-title":"Association between pathologic response and survival after neoadjuvant therapy in lung cancer","volume":"30","author":"Deutsch","year":"2024","journal-title":"Nat. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"230191","DOI":"10.1183\/20734735.0191-2023","article-title":"Mediastinal staging of nonsmall cell lung cancer: What\u2019s new?","volume":"21","author":"Bradley","year":"2025","journal-title":"Breathe"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/S0022-5223(96)70317-3","article-title":"Mediastinal lymph node staging of non-small-cell lung cancer: A prospective comparison of computed tomography and positron emission tomography","volume":"111","author":"Scott","year":"1996","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"6116","DOI":"10.1007\/s00330-020-07572-4","article-title":"Introducing the Node Reporting and Data System 1.0 (Node-RADS): A concept for standardized assessment of lymph nodes in cancer","volume":"31","author":"Elsholtz","year":"2021","journal-title":"Eur. Radiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1007\/s00330-024-11160-1","article-title":"Node-RADS: A systematic review and meta-analysis of diagnostic performance, category-wise malignancy rates, and inter-observer reliability","volume":"35","author":"Zhong","year":"2025","journal-title":"Eur. Radiol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Qiao, J., Zhang, X., Du, M., Wang, P., and Xin, J. (2022). 18F-FDG PET\/CT radiomics nomogram for predicting occult lymph node metastasis of non-small cell lung cancer. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.974934"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"4292","DOI":"10.7150\/jca.119881","article-title":"The Prognostic Value of Lymph Node Downstaging Following Neoadjuvant Chemoimmunotherapy for non-small cell lung cancer","volume":"16","author":"Guo","year":"2025","journal-title":"J. Cancer"},{"key":"ref_11","unstructured":"Oncology Society of Chinese Medical Association (2024). Chinese Medical Association guideline for clinical diagnosis and treatment of lung cancer (2024 edition). Chin. J. Oncol., 46, 805\u2013843."},{"key":"ref_12","first-page":"4","article-title":"NCCN Guidelines\u00ae Insights: Non-small cell lung cancer, Version 2.2023","volume":"21","author":"Ettinger","year":"2023","journal-title":"J. Natl. Compr. Cancer Netw."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1056\/NEJMoa2202170","article-title":"Neoadjuvant Nivolumab plus Chemotherapy in Resectable Lung Cancer","volume":"386","author":"Forde","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"496","DOI":"10.21037\/tlcr.2020.03.08","article-title":"Mediastinal staging for non-small cell lung cancer","volume":"10","year":"2021","journal-title":"Transl. Lung Cancer Res."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Leonardo, C., Flammia, R.S., Lucciola, S., Proietti, F., Pecoraro, M., Bucca, B., Licari, L.C., Borrelli, A., Bologna, E., and Landini, N. (2023). Performance of Node-RADS Scoring System for a Standardized Assessment of Regional Lymph Nodes in Bladder Cancer Patients. Cancers, 15.","DOI":"10.3390\/cancers15030580"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1007\/s11547-024-01824-9","article-title":"The performance of the node reporting and data system 1.0 (Node-RADS) and DWI-MRI in staging patients with cervical carcinoma according to the new FIGO classification (2018)","volume":"129","author":"Ninkova","year":"2024","journal-title":"Radiol. Med."},{"key":"ref_17","first-page":"989","article-title":"Node-RADS for preoperative locoregional nodal staging of endometrial cancer: Reproducibility and accuracy assessment using CT and MRI","volume":"36","author":"Bonatti","year":"2026","journal-title":"Oncology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s40644-022-00506-x","article-title":"CT texture analysis and node-RADS CT score of mediastinal lymph nodes: Diagnostic performance in lung cancer patients","volume":"22","author":"Meyer","year":"2022","journal-title":"Cancer Imaging"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Sun, Y., Wen, L., Xiang, W., Luo, X., Chen, L., Yang, X., Yang, Y., Zhang, Y., Yu, S., and Xiao, H. (2025). Added value of pretreatment CT-based Node-RADS score for predicting survival outcome of locally advanced gastric cancer: Compared with clinical N stage. BMC Cancer, 25.","DOI":"10.1186\/s12885-025-14032-z"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"112525","DOI":"10.1016\/j.ejrad.2025.112525","article-title":"Prognostic and diagnostic value of node-RADS before and after neoadjuvant therapy in locally advanced gastric cancer","volume":"194","author":"Dilek","year":"2026","journal-title":"Eur. J. Radiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"5480","DOI":"10.1007\/s00330-025-11446-y","article-title":"Node-RADS category on preoperative CT predicts prognosis in patients with papillary renal cell carcinoma","volume":"35","author":"Li","year":"2025","journal-title":"Eur. Radiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"6068","DOI":"10.1007\/s00330-026-12403-z","article-title":"Enhancing Node-RADS for preoperative assessment of cervical lymph node metastases in papillary thyroid carcinoma: Validation and modification","volume":"36","author":"Wang","year":"2026","journal-title":"Eur. Radiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"112079","DOI":"10.1016\/j.ejrad.2025.112079","article-title":"The Node Reporting and Data System (Node-RADS) for standardized MRI evaluation of lymph nodes in endometrial cancer, integrated with clinicopathological and molecular data","volume":"187","author":"Riccardi","year":"2025","journal-title":"Eur. J. Radiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"545","DOI":"10.21147\/j.issn.1000-9604.2024.05.07","article-title":"Deep learning-based automatic pipeline system for predicting lateral cervical lymph node metastasis in patients with papillary thyroid carcinoma using computed tomography: A multi-center study","volume":"36","author":"Yu","year":"2024","journal-title":"Chin. J. Cancer Res."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Du, J., Yang, Q., Sun, Y., Shi, P., Xu, H., Chen, X., Dong, T., Shi, W., Wang, Y., and Song, Z. (2023). Risk factors for central lymph node metastasis in patients with papillary thyroid carcinoma: A retrospective study. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1288527"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/13\/2021\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T06:22:50Z","timestamp":1782714170000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/13\/2021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,29]]},"references-count":25,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["diagnostics16132021"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics16132021","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,29]]}}}