{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T09:50:09Z","timestamp":1782899409111,"version":"3.54.5"},"reference-count":13,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: Preoperative identification of invasive carcinoma in patients with ductal carcinoma in situ (DCIS) remains challenging. While individual imaging findings have been widely investigated, the significance of mass findings identified on both mammography and ultrasonography remains less clearly defined. Methods: This retrospective study included 125 patients with DCIS who underwent both mammography and ultrasonography (US). Imaging findings were categorized as no mass on either modality, mass detected on a single modality, or mass findings identified on both mammography and ultrasonography. Associations between imaging patterns and invasive carcinoma were evaluated using descriptive analyses. Results: The proportion of invasive carcinoma was highest among patients with mass findings identified on both mammography and ultrasonography. Invasive carcinoma was observed in 6 of 71 patients (8.5%) with no mass on either modality, 5 of 37 patients (13.5%) with a mass detected on a single modality, and 8 of 17 patients (47.1%) with mass findings identified on both mammography and ultrasonography. However, substantial overlap between imaging categories remained present. Conclusions: Mass findings identified on both mammography and ultrasonography were more frequently observed in DCIS cases with invasive carcinoma. However, substantial overlap between imaging categories remained present, limiting reliable distinction at the individual patient level.<\/jats:p>","DOI":"10.3390\/diagnostics16132062","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T08:19:02Z","timestamp":1782893942000},"page":"2062","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Patient-Level Mass Findings on Mammography and Ultrasonography in Ductal Carcinoma In Situ: Association with Invasive Carcinoma"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4297-4930","authenticated-orcid":false,"given":"Ozlem","family":"Unal","sequence":"first","affiliation":[{"name":"Radiology, Ankara Y\u0131ld\u0131r\u0131m Beyaz\u0131t University, Ankara 06800, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Servet","family":"Kocaoz","sequence":"additional","affiliation":[{"name":"General Surgery, Ankara Bilkent City Hospital, Ankara 06800, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulay","family":"Gencer","sequence":"additional","affiliation":[{"name":"Radiology, Ankara Bilkent City Hospital, Ankara 06800, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eda Sener","family":"Alc\u0131n","sequence":"additional","affiliation":[{"name":"Radiology, Ankara Bilkent City Hospital, Ankara 06800, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berkan","family":"Alc\u0131n","sequence":"additional","affiliation":[{"name":"Radiology, Ankara Bilkent City Hospital, Ankara 06800, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fazl\u0131","family":"Erdogan","sequence":"additional","affiliation":[{"name":"Pathology, Ankara Y\u0131ld\u0131r\u0131m Beyaz\u0131t University, Ankara 06760, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1001\/jama.1996.03530360023033","article-title":"Incidence of and treatment for ductal carcinoma in situ of the breast","volume":"275","author":"Ernster","year":"1996","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1093\/jnci\/94.20.1546","article-title":"Detection of ductal carcinoma in situ in women undergoing screening mammography","volume":"94","author":"Ernster","year":"2002","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1148\/radiol.11102368","article-title":"Ductal carcinoma in situ at core-needle biopsy: Meta-analysis of underestimation and predictors of invasive breast cancer","volume":"260","author":"Brennan","year":"2011","journal-title":"Radiology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/cncr.22435","article-title":"Underestimation of malignancy of breast core-needle biopsy: Concepts and precise overall and category-specific estimates","volume":"109","author":"Houssami","year":"2007","journal-title":"Cancer"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s10434-000-0015-z","article-title":"Sentinel node biopsy in ductal carcinoma in situ patients","volume":"7","author":"Pendas","year":"2000","journal-title":"Ann. Surg. Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1002\/bjs.6162","article-title":"Meta-analysis of sentinel node biopsy in ductal carcinoma in situ of the breast","volume":"95","author":"Ansari","year":"2008","journal-title":"Br. J. Surg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1001\/jamaoncol.2015.2510","article-title":"Breast cancer mortality after a diagnosis of ductal carcinoma in situ","volume":"1","author":"Narod","year":"2015","journal-title":"JAMA Oncol."},{"key":"ref_8","first-page":"700","article-title":"The natural history of low-grade ductal carcinoma in situ of the breast in women treated by biopsy only revealed over 30 years of follow-up","volume":"97","author":"Sanders","year":"2005","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.21614\/chirurgia.116.5.suppl.S50","article-title":"Ductal carcinoma in situ: Interventional diagnosis","volume":"116","author":"Lisencu","year":"2021","journal-title":"Chirurgia"},{"key":"ref_10","first-page":"3053","article-title":"Surgical upstaging rates for ductal carcinoma in situ: Implications for active surveillance trials","volume":"12","author":"Grimm","year":"2020","journal-title":"Cancers"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1148\/radiol.2333031484","article-title":"Diagnostic accuracy of mammography, clinical examination, US, and MR imaging in preoperative assessment of breast cancer","volume":"233","author":"Berg","year":"2004","journal-title":"Radiology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s10396-023-01334-7","article-title":"Features of ductal carcinoma in situ ultrasound images","volume":"50","author":"Watanabe","year":"2023","journal-title":"J. Med. Ultrason."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s10549-024-07599-x","article-title":"Clinicopathologic characteristics of ductal carcinoma in situ and risk of subsequent invasive breast cancer: A multicenter, population-based cohort study","volume":"210","author":"Rohan","year":"2025","journal-title":"Breast Cancer Res. Treat."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/13\/2062\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T09:26:21Z","timestamp":1782897981000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/13\/2062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,1]]},"references-count":13,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["diagnostics16132062"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics16132062","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,1]]}}}