{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:24:31Z","timestamp":1788348271196,"version":"build-2803163510"},"reference-count":22,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: Catatonia is a severe transdiagnostic neuropsychiatric syndrome for which accessible biological correlates remain insufficiently characterized. This study explored whether complete blood count (CBC)-derived inflammatory indices differ between psychiatric inpatients with catatonia and matched psychiatric controls without catatonia. Methods: This retrospective matched case\u2013control study included 46 patients with catatonia and 46 psychiatric controls selected from the same clinical setting and study period. Controls were frequency-matched by sex, age distribution, and broad psychiatric diagnosis. CBC parameters obtained within the first 24 h of admission were used to calculate the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune\u2013inflammation index (SII), and systemic inflammation response index (SIRI). Group comparisons, adjusted log\u2013linear regression models, Spearman correlations with documented catatonic signs, and exploratory receiver operating characteristic analyses were performed. Results: SII was higher in patients with catatonia than in controls and remained significant after Bonferroni correction (median 584 [IQR 468\u2013823] vs. 476 [IQR 339\u2013619], Bonferroni-adjusted p = 0.032). In secondary adjusted models, catatonia was associated with higher SII and SIRI after adjustment for body mass index, smoking, antipsychotic exposure, diabetes mellitus, and arterial hypertension. No inflammatory index correlated significantly with the number of documented catatonic signs after correction. Exploratory discrimination was poor to fair, with SII showing the highest AUC (0.665, 95% CI 0.550\u20130.773). Conclusions: CBC-derived indices, particularly SII, may reflect systemic inflammatory or physiological stress burden in catatonia, but they should be interpreted as exploratory markers rather than diagnostic biomarkers.<\/jats:p>","DOI":"10.3390\/diagnostics16132110","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T08:05:38Z","timestamp":1783325138000},"page":"2110","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Complete Blood Count-Derived Inflammatory Indices in Catatonia: A Retrospective Matched Case\u2013Control Study"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4967-8165","authenticated-orcid":false,"given":"Octavia","family":"C\u0103p\u0103\u021b\u00een\u0103","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Iuliu Ha\u021bieganu University of Medicine and Pharmacy, 400347 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adela","family":"Hanga","sequence":"additional","affiliation":[{"name":"County Emergency Hospital Cluj-Napoca, 400347 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Tivadar","sequence":"additional","affiliation":[{"name":"County Emergency Hospital Cluj-Napoca, 400347 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1987-0228","authenticated-orcid":false,"given":"Andrei","family":"Hopulele-Petri","sequence":"additional","affiliation":[{"name":"\u201cDr. Constantin Papilian\u201d Emergency Military Clinical Hospital, 22 General Traian Mo\u0219oiu Street, 400132 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Paval","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Iuliu Ha\u021bieganu University of Medicine and Pharmacy, 400347 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9971-4975","authenticated-orcid":false,"given":"Mihaela","family":"Fadgyas Stanculete","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Iuliu Ha\u021bieganu University of Medicine and Pharmacy, 400347 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1177\/02698811231158232","article-title":"Evidence-Based Consensus Guidelines for the Management of Catatonia: Recommendations from the British Association for Psychopharmacology","volume":"37","author":"Rogers","year":"2023","journal-title":"J. Psychopharmacol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41572-024-00534-w","article-title":"Catatonia","volume":"10","author":"Hirjak","year":"2024","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.schres.2022.08.002","article-title":"Describing the Features of Catatonia: A Comparative Phenotypic Analysis","volume":"263","author":"Oldham","year":"2024","journal-title":"Schizophr. Res."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Capatina, O., Hanga, A., Tivadar, S., Paval, D., and Fadgyas Stanculete, M. (2025). Recognizing Catatonia beyond Hypokinesis: Features Linked to Underdiagnosis and Training Targets. J. Clin. Med., 14.","DOI":"10.3390\/jcm14238382"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.schres.2023.03.013","article-title":"Molecular and Immunological Origins of Catatonia","volume":"263","author":"Beach","year":"2024","journal-title":"Schizophr. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/S2215-0366(19)30190-7","article-title":"Catatonia and the Immune System: A Review","volume":"6","author":"Rogers","year":"2019","journal-title":"Lancet Psychiatry"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1177\/1039856220908172","article-title":"Neutrophil-Lymphocyte Ratio: A Simple, Accessible Measure of Inflammation, Morbidity and Prognosis in Psychiatric Disorders?","volume":"28","author":"Zulfic","year":"2020","journal-title":"Australas. Psychiatry"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"8","DOI":"10.4103\/tjem.tjem_198_23","article-title":"Unraveling the Clinical Significance and Prognostic Value of the Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, Systemic Immune-Inflammation Index, Systemic Inflammation Response Index, and Delta Neutrophil Index: An Extensive Literature Review","volume":"24","author":"Islam","year":"2024","journal-title":"Turk. J. Emerg. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1590\/0101-60830000000232","article-title":"Neutrophil-Lymphocyte Ratio in Catatonia","volume":"47","year":"2020","journal-title":"Arch. Clin. Psychiatry"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.pnpbp.2018.03.012","article-title":"Neutrophil\/Lymphocyte Ratio and Platelet\/Lymphocyte Ratio in Mood Disorders: A Meta-Analysis","volume":"84","author":"Mazza","year":"2018","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1080\/15622975.2019.1583371","article-title":"Neutrophil-Lymphocyte Ratio, Monocyte-Lymphocyte Ratio and Platelet-Lymphocyte Ratio in Non-Affective Psychosis: A Meta-Analysis and Systematic Review","volume":"21","author":"Mazza","year":"2020","journal-title":"World J. Biol. Psychiatry"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e036859","DOI":"10.1136\/bmjopen-2020-036859","article-title":"Neutrophil-Lymphocyte Ratio across Psychiatric Diagnoses: A Cross-Sectional Study Using Electronic Health Records","volume":"10","author":"Brinn","year":"2020","journal-title":"BMJ Open"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1080\/08039488.2017.1340517","article-title":"A Comparison of the Neutrophil-Lymphocyte, Platelet-Lymphocyte and Monocyte-Lymphocyte Ratios in Schizophrenia and Bipolar Disorder Patients: A Retrospective File Review","volume":"71","year":"2017","journal-title":"Nord. J. Psychiatry"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.schres.2018.12.017","article-title":"Neutrophil-to-Lymphocyte Ratio in Schizophrenia: A Systematic Review and Meta-Analysis","volume":"206","author":"Karageorgiou","year":"2019","journal-title":"Schizophr. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1017\/S0033291721004402","article-title":"Catatonia: Demographic, Clinical and Laboratory Associations","volume":"53","author":"Rogers","year":"2023","journal-title":"Psychol. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12991-023-00471-0","article-title":"Catatonia-Like Behavior and Immune Activation: A Crosstalk between Psychopathology and Pathology in Schizophrenia","volume":"22","author":"Messina","year":"2023","journal-title":"Ann. Gen. Psychiatry"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.54005\/geneltip.1609236","article-title":"Examining Subclinical Inflammation in Major Depressive Disorder Subtypes","volume":"35","author":"Aslan","year":"2025","journal-title":"Genel T\u0131p Derg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"472","DOI":"10.4149\/BLL_2024_73","article-title":"Evaluation of Systemic Immune Inflammation Index and Neutrophil-to-Lymphocyte Ratio in Schizophrenia, Bipolar Disorder and Depression","volume":"125","author":"Canli","year":"2024","journal-title":"Bratisl. Med. J."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"\u0160agud, M., Mad\u017earac, Z., Nedic Erjavec, G., \u0160imunovi\u0107 Filip\u010di\u0107, I., Mikuli\u0107, F.L., Rogi\u0107, D., Brada\u0161, Z., Bajs Janovi\u0107, M., and Pivac, N. (2023). The Associations of Neutrophil-Lymphocyte, Platelet-Lymphocyte, Monocyte-Lymphocyte Ratios and Immune-Inflammation Index with Negative Symptoms in Patients with Schizophrenia. Biomolecules, 13.","DOI":"10.3390\/biom13020297"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Wei, Y., Wang, T., Li, G., Feng, J., Deng, L., Xu, H., Yin, L., Ma, J., Chen, D., and Chen, J. (2022). Investigation of Systemic Immune-Inflammation Index, Neutrophil\/High-Density Lipoprotein Ratio, Lymphocyte\/High-Density Lipoprotein Ratio, and Monocyte\/High-Density Lipoprotein Ratio as Indicators of Inflammation in Patients with Schizophrenia and Bipolar Disorder. Front. Psychiatry, 13.","DOI":"10.3389\/fpsyt.2022.941728"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.psychres.2018.11.043","article-title":"Neutrophil\/Lymphocyte, Platelet\/Lymphocyte and Monocyte\/Lymphocyte Ratios in Different Stages of Schizophrenia","volume":"271","year":"2019","journal-title":"Psychiatry Res."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Fadgyas-Stanculete, M., and Capatina, O.O. (2025). Glutamate-Based Therapeutic Strategies for Schizophrenia: Emerging Approaches Beyond Dopamine. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26094331"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/13\/2110\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T09:06:33Z","timestamp":1783328793000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/13\/2110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,6]]},"references-count":22,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["diagnostics16132110"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics16132110","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,6]]}}}