{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T06:05:06Z","timestamp":1784009106662,"version":"3.55.0"},"reference-count":36,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Objectives: This study aimed to investigate imaging features associated with malignancy and to differentiate true non-mass lesions from transient non-mass ABUS findings on automated breast ultrasound (ABUS). Methods: This retrospective study included 133 women with non-mass lesions, each contributing a single lesion assessed as BI-RADS categories 0, 4, or 5 on ABUS between January 2020 and October 2022. We analyzed multiple ABUS imaging features, including background echotexture, distribution, microcalcification-like echogenic foci, posterior shadowing, architectural distortion on axial and coronal views, and volume change. These findings were statistically compared according to pathologic results for malignancy and ultrasonographic correlation for true versus transient non-mass ABUS findings. Results: Among the 133 lesions, 15 (11.3%) were malignant and 65 (48.9%) were transient non-mass ABUS findings. Segmental distribution (odds ratio [OR] = 40.42; 95% confidence interval [CI], 4.45\u2013367.27; p = 0.001) and coronal architectural distortion (OR = 53.59; 95% CI, 6.26\u2013458.90; p &lt; 0.001) showed exploratory associations with malignancy. A non-heterogeneous background echotexture (OR = 0.07; 95% CI, 0.02\u20130.33; p = 0.001), lack of posterior shadowing (OR = 0.14; 95% CI, 0.03\u20130.60; p = 0.008), and volume change (OR = 15.79; 95% CI, 1.47\u2013170.12; p = 0.023) were associated with true lesions. Conclusions: Segmental distribution and coronal architectural distortion were associated with malignancy on ABUS in this exploratory study. Lack of posterior shadowing and the presence of volume change were associated with true lesions, while heterogeneous background echotexture was associated with transient non-mass ABUS findings. These ABUS findings may contribute to the characterization of non-mass lesions but, given the small number of malignant lesions, require cautious interpretation and validation in larger studies.<\/jats:p>","DOI":"10.3390\/diagnostics16142186","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T05:32:01Z","timestamp":1784007121000},"page":"2186","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Non-Mass Lesions on Automated Breast Ultrasound: An Exploratory Analysis of Imaging Features Associated with Malignancy and Differentiation from Transient Non-Mass ABUS Findings"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7709-0964","authenticated-orcid":false,"given":"Gahyeon","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Radiology, Inje University Haeundae Paik Hospital, Busan 48108, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology, Inje University Haeundae Paik Hospital, Busan 48108, Republic of Korea"},{"name":"Department of Radiology, Miraero Hospital, Busan 46544, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Kyung","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Radiology, Inje University Haeundae Paik Hospital, Busan 48108, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suk Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology, Inje University Haeundae Paik Hospital, Busan 48108, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"ref_1","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"83","DOI":"10.14366\/usg.18016","article-title":"Image quality and artifacts in automated breast ultrasonography","volume":"38","author":"Kim","year":"2019","journal-title":"Ultrasonography"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"698","DOI":"10.21037\/gs.2019.11.18","article-title":"Diagnostic value of an automated breast volume scanner compared with a hand-held ultrasound: A meta-analysis","volume":"8","author":"Zhang","year":"2019","journal-title":"Gland. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"165","DOI":"10.14366\/usg.15002","article-title":"Current status of automated breast ultrasonography","volume":"34","author":"Shin","year":"2015","journal-title":"Ultrasonography"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e29547","DOI":"10.1097\/MD.0000000000029547","article-title":"Comparison of the background echotexture between automated breast ultrasound and handheld breast ultrasound","volume":"101","author":"Kim","year":"2022","journal-title":"Medicine"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"027002","DOI":"10.1117\/1.JMI.3.2.027002","article-title":"Automated quality assessment in three-dimensional breast ultrasound images","volume":"3","author":"Schwaab","year":"2016","journal-title":"J. Med. Imaging"},{"key":"ref_7","first-page":"65M","article-title":"Breast Imaging Artifacts","volume":"87","author":"Odle","year":"2015","journal-title":"Radiol. Technol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Ibraheem, S.A., Mahmud, R., Mohamad Saini, S., Abu Hassan, H., and Keiteb, A.S. (2023). Diagnostic Performance of Prototype Handheld Ultrasound According to the Fifth Edition of BI-RADS for Breast Ultrasound Compared with Automated Breast Ultrasound among Females with Positive Lumps. Diagnostics, 13.","DOI":"10.3390\/diagnostics13061065"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ejrad.2018.01.002","article-title":"Evaluation of an automated breast volume scanner according to the fifth edition of BI-RADS for breast ultrasound compared with hand-held ultrasound","volume":"99","author":"Choi","year":"2018","journal-title":"Eur. J. Radiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"264","DOI":"10.14366\/usg.18055","article-title":"Reliability of automated versus handheld breast ultrasound examinations of suspicious breast masses","volume":"38","author":"Yun","year":"2019","journal-title":"Ultrasonography"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.acra.2017.01.021","article-title":"Diagnostic Performance of Automated Breast Volume Scanning (ABVS) Compared to Handheld Ultrasonography With Breast MRI as the Gold Standard","volume":"24","author":"Schmachtenberg","year":"2017","journal-title":"Acad. Radiol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Mun, H.S., Ko, E.Y., Han, B.K., Ko, E.S., Choi, J.S., Kim, H., Kim, M.K., and Kim, J. (2025). Comparative Analysis of Automated and Handheld Breast Ultrasound Findings for Small (<\/=1 cm) Breast Cancers Based on BI-RADS Category. Diagnostics, 15.","DOI":"10.3390\/diagnostics15020212"},{"key":"ref_13","unstructured":"Newell, M., Destounis, S.V., Leung, J.W.T., DeMartini, W.B., Lee, C.H., and Eby, P.R. (2025). ACR BI-RADS\u00ae v2025 Manual, American College of Radiology."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1007\/s00330-020-07168-y","article-title":"Non-mass lesions detected by breast US: Stratification of cancer risk for clinical management","volume":"31","author":"Park","year":"2021","journal-title":"Eur. Radiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1148\/rg.2020190125","article-title":"Nonmass Findings at Breast US: Definition, Classifications, and Differential Diagnosis","volume":"40","author":"Choe","year":"2020","journal-title":"Radiographics"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1093\/jbi\/wbad077","article-title":"Nonmass Lesions on Breast US: An International Perspective on Clinical Use and Outcomes","volume":"6","author":"Choi","year":"2024","journal-title":"J. Breast Imaging"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Zhang, J., Cai, L., Chen, L., Pang, X., Chen, M., Yan, D., Liu, J., and Luo, L. (2021). Re-evaluation of high-risk breast mammography lesions by target ultrasound and ABUS of breast non-mass-like lesions. BMC Med. Imaging, 21.","DOI":"10.1186\/s12880-021-00665-6"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s12282-012-0364-z","article-title":"Non-mass-like lesions on breast ultrasonography: A systematic review","volume":"19","author":"Uematsu","year":"2012","journal-title":"Breast Cancer"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Boca Bene, I., Ciurea, A.I., Ciortea, C.A., and Dudea, S.M. (2021). Pros and Cons for Automated Breast Ultrasound (ABUS): A Narrative Review. J. Pers. Med., 11.","DOI":"10.3390\/jpm11080703"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ejrad.2014.10.010","article-title":"Non-mass-like breast lesions at ultrasonography: Feature analysis and BI-RADS assessment","volume":"84","author":"Ko","year":"2015","journal-title":"Eur. J. Radiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3542","DOI":"10.1007\/s00330-015-4201-6","article-title":"Additional diagnostic value of shear-wave elastography and color Doppler US for evaluation of breast non-mass lesions detected at B-mode US","volume":"26","author":"Choi","year":"2016","journal-title":"Eur. Radiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1177\/0284185116683574","article-title":"Non-mass breast lesions on ultrasound: Final outcomes and predictors of malignancy","volume":"58","author":"Park","year":"2017","journal-title":"Acta Radiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s00330-009-1546-8","article-title":"Ultrasonographic alterations associated with the dilatation of mammary ducts: Feature analysis and BI-RADS assessment","volume":"20","author":"Hsu","year":"2010","journal-title":"Eur. Radiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1007\/s00330-005-2755-4","article-title":"Diagnostic usefulness of segmental and linear enhancement in dynamic breast MRI","volume":"15","author":"Leutner","year":"2005","journal-title":"Eur. Radiol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Aydin, H., Bozkurt, C., Hayme, S., Bilge, A.C., Oztekin, P.S., Avdan Aslan, A., Ozcan, I., Gultekin, S., Eren, A., and Durur Subasi, I. (2025). Segmental Non-Mass Enhancement Features in Breast Magnetic Resonance Imaging: A Multicenter Retrospective Study of Histopathologic Correlations. Diagnostics, 15.","DOI":"10.20944\/preprints202508.1402.v1"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/j.acra.2018.02.014","article-title":"Automated Breast Ultrasonography (ABUS) in the Screening and Diagnostic Setting: Indications and Practical Use","volume":"25","author":"Rella","year":"2018","journal-title":"Acad. Radiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1007\/s11547-014-0493-x","article-title":"Non-mass-like lesions on breast ultrasound: Classification and correlation with histology","volume":"120","author":"Wang","year":"2015","journal-title":"Radiol. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1016\/j.ultrasmedbio.2018.05.005","article-title":"Non-Mass Breast Lesions on Ultrasound: Feature Exploration and Multimode Ultrasonic Diagnosis","volume":"44","author":"Zhang","year":"2018","journal-title":"Ultrasound Med. Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/1754-9485.12080","article-title":"Mammographic and ultrasound features of invasive lobular carcinoma of the breast","volume":"58","author":"Porter","year":"2014","journal-title":"J. Med. Imaging Radiat. Oncol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/S0720-048X(02)00020-7","article-title":"Sclerosing adenosis: Mammographic and ultrasonographic findings with clinical and histopathological correlation","volume":"44","author":"Memis","year":"2002","journal-title":"Eur. J. Radiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1177\/0284185117695665","article-title":"Background echotexture classification in breast ultrasound: Inter-observer agreement study","volume":"58","author":"Kim","year":"2017","journal-title":"Acta Radiol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Carson, P.L., Wang, B., LeCarpentier, G.L., Goodsitt, M.M., Lashbrook, C., Pinsky, R., Narayanasamy, G., Fowlkes, J.B., and Saitou, K. (2010). Local compression in automated breast ultrasound in the mammographic geometry. Proceedings of the 2010 IEEE International Ultrasonics Symposium, IEEE.","DOI":"10.1109\/ULTSYM.2010.5935830"},{"key":"ref_33","unstructured":"(2020). Guideline for Breast Ultrasound: Management and Diagnosis, Japan Association of Breast and Thyroid Sonology."},{"key":"ref_34","unstructured":"DeMartini, W.B., Destounis, S.V., Eby, P.R., and Leung, J.W.T. (2023). BI-RADS update: The edition formerly known as fifth. Proceedings of the 2023 SBI Breast Imaging Symposium, National Harbor, MD, USA, 4\u20137 May 2023, Society of Breast Imaging."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"446","DOI":"10.11152\/mu-871","article-title":"Non-mass lesions on screening breast ultrasound","volume":"18","author":"Lee","year":"2016","journal-title":"Med. Ultrason."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"421","DOI":"10.7863\/ultra.33.3.421","article-title":"Nonmasslike lesions on breast sonography: Comparison between benign and malignant lesions","volume":"33","author":"Kim","year":"2014","journal-title":"J. Ultrasound Med."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/14\/2186\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T05:33:10Z","timestamp":1784007190000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/14\/2186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,14]]},"references-count":36,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["diagnostics16142186"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics16142186","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,14]]}}}