{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T19:00:42Z","timestamp":1785438042762,"version":"3.56.0"},"reference-count":17,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Victor Babe\u0219 University of Medicine and Pharmacy Timi\u0219oara"},{"id":[{"id":"https:\/\/ror.org\/00afdp487","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: MDRO colonization at ICU admission may identify patients at increased risk for hospital-acquired infection (HAI), but its independent predictive value remains incompletely defined. Methods: We conducted a retrospective observational study of 560 consecutive ICU admissions (July\u2013October 2024). Admission screening assessed colonization with extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales, carbapenem-resistant Enterobacterales (CRE), and vancomycin-resistant enterococci (VRE). The primary outcome was microbiologically confirmed HAI; the secondary outcome was in-hospital mortality. Associations were evaluated using multivariable logistic regression, ROC\/AUC analysis, mediation analysis, and a sensitivity analysis restricted to first admissions. Results: Of 560 admissions, 223 were screen-positive and 283 screen-negative. HAI occurred in 49 patients (8.8%). Positive screening was associated with increased HAI odds, narrowly missing significance in the primary adjusted analysis (OR 1.81, 95% CI 0.96\u20133.41, p = 0.065) but reaching significance in the first-admission sensitivity analysis (OR 2.09, p = 0.034). CRE showed the strongest adjusted association with HAI (OR 2.33, 95% CI 1.21\u20134.51, p = 0.012). Screening alone showed poor discrimination (AUC 0.574); combined with clinical variables, discrimination improved substantially (AUC 0.788). Conclusions: MDRO admission screening was associated with increased HAI odds, particularly for CRE, though screening alone has limited predictive performance. Larger prospective studies are needed to confirm these findings.<\/jats:p>","DOI":"10.3390\/diagnostics16142221","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T08:08:34Z","timestamp":1784189314000},"page":"2221","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["ICU Admission Screening for Multidrug-Resistant Organism Colonization and Subsequent Infection Risk: A Pilot Study"],"prefix":"10.3390","volume":"16","author":[{"given":"Patricia","family":"Ionitoiu Chirodea","sequence":"first","affiliation":[{"name":"Faculty of Medicine, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"},{"name":"Clinic of Anaesthesia and Intensive Care, Emergency County Hospital \u201cPius Br\u00eenzeu\u201d, 300723 Timi\u0219oara, Romania"},{"name":"Doctoral School, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania"},{"name":"Anaesthesia and Intensive Care Research Center (CCATITM), \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8751-6813","authenticated-orcid":false,"given":"Stelian Adrian","family":"Ritiu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"},{"name":"Clinic of Anaesthesia and Intensive Care, Emergency County Hospital \u201cPius Br\u00eenzeu\u201d, 300723 Timi\u0219oara, Romania"},{"name":"Doctoral School, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania"},{"name":"Anaesthesia and Intensive Care Research Center (CCATITM), \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4065-3650","authenticated-orcid":false,"given":"Marius","family":"Papurica","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"},{"name":"Clinic of Anaesthesia and Intensive Care, Emergency County Hospital \u201cPius Br\u00eenzeu\u201d, 300723 Timi\u0219oara, Romania"},{"name":"Anaesthesia and Intensive Care Research Center (CCATITM), \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorel","family":"Sandesc","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"},{"name":"Clinic of Anaesthesia and Intensive Care, Emergency County Hospital \u201cPius Br\u00eenzeu\u201d, 300723 Timi\u0219oara, Romania"},{"name":"Anaesthesia and Intensive Care Research Center (CCATITM), \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1034-923X","authenticated-orcid":false,"given":"Daiana","family":"Toma","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"},{"name":"Clinic of Anaesthesia and Intensive Care, Emergency County Hospital \u201cPius Br\u00eenzeu\u201d, 300723 Timi\u0219oara, Romania"},{"name":"Doctoral School, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania"},{"name":"Anaesthesia and Intensive Care Research Center (CCATITM), \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelina","family":"Baloi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"},{"name":"Clinic of Anaesthesia and Intensive Care, Emergency County Hospital \u201cPius Br\u00eenzeu\u201d, 300723 Timi\u0219oara, Romania"},{"name":"Doctoral School, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania"},{"name":"Anaesthesia and Intensive Care Research Center (CCATITM), \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9245-5883","authenticated-orcid":false,"given":"Monica","family":"Licker","sequence":"additional","affiliation":[{"name":"Microbiology Department, Multidisciplinary Research Center on Antimicrobial Resistance, \u2018Victor Babes\u2019 University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corina","family":"Musuroi","sequence":"additional","affiliation":[{"name":"Microbiology Department, Multidisciplinary Research Center on Antimicrobial Resistance, \u2018Victor Babes\u2019 University of Medicine and Pharmacy, 300041 Timisoara, Romania"},{"name":"Microbiology Laboratory Pius Brinzeu Emergency Clinical County Hospital (for Licker and Musuroi), 500723 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Irina","family":"Barata","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, \u201cVasile Goldis\u201d Western University of Arad, Blvd. Revolutiei, No. 96, 310025 Arad, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3432-9168","authenticated-orcid":false,"given":"Ovidiu","family":"Bedreag","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"},{"name":"Clinic of Anaesthesia and Intensive Care, Emergency County Hospital \u201cPius Br\u00eenzeu\u201d, 300723 Timi\u0219oara, Romania"},{"name":"Anaesthesia and Intensive Care Research Center (CCATITM), \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2022). 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Medica"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/14\/2221\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T08:30:46Z","timestamp":1784190646000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/14\/2221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,16]]},"references-count":17,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["diagnostics16142221"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics16142221","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,16]]}}}