{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:00:56Z","timestamp":1785420056119,"version":"3.56.0"},"reference-count":106,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shenzhen Clinical Research Center for Rare Diseases","award":["LCYSSQ20220823091402005"],"award-info":[{"award-number":["LCYSSQ20220823091402005"]}]},{"award":["LCYSSQ20220823091402005"],"award-info":[{"award-number":["LCYSSQ20220823091402005"]}],"id":[{"id":"https:\/\/ror.org\/00phd3t88","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"publisher","award":["SZSM202311022"],"award-info":[{"award-number":["SZSM202311022"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Light chain (AL) amyloidosis is a systemic disorder caused by plasma cell dyscrasia, with cardiac involvement being the primary determinant of prognosis. Survival outcomes vary significantly across disease stages. This heterogeneity underscores a critical need for early diagnosis, precise risk stratification, and response-adapted therapy. In this context, multimodality imaging has emerged as an indispensable non-invasive tool, providing crucial insights for clinical decision-making. This review synthesizes recent advances in the application of key imaging modalities\u2014echocardiography, magnetic resonance imaging, and nuclear medicine imaging\u2014for evaluating AL amyloidosis. We highlight how these techniques have shifted the paradigm from anatomical assessment to quantitative, multiparametric tissue characterization, ultimately guiding personalized patient management.<\/jats:p>","DOI":"10.3390\/diagnostics16142225","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:55:59Z","timestamp":1784249759000},"page":"2225","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Imaging Advances in Light Chain Amyloidosis"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5726-4002","authenticated-orcid":false,"given":"Miaoling","family":"Qiu","sequence":"first","affiliation":[{"name":"Department of Hematology, The University of Hong Kong-Shenzhen Hospital, Shenzhen 518053, China"},{"name":"Shenzhen Clinical Research Center for Rare Diseases, Shenzhen 518053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaini","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Hematology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Hematology, The University of Hong Kong-Shenzhen Hospital, Shenzhen 518053, China"},{"name":"Shenzhen Clinical Research Center for Rare Diseases, Shenzhen 518053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology, The University of Hong Kong-Shenzhen Hospital, Shenzhen 518053, China"},{"name":"Shenzhen Clinical Research Center for Rare Diseases, Shenzhen 518053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4549-0694","authenticated-orcid":false,"given":"Jian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1056\/NEJMra2304088","article-title":"Systemic Light Chain Amyloidosis","volume":"390","author":"Sanchorawala","year":"2024","journal-title":"N. 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