{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T19:00:40Z","timestamp":1785438040592,"version":"3.56.0"},"reference-count":94,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Research, Technology and Space","doi-asserted-by":"publisher","award":["01EO2102"],"award-info":[{"award-number":["01EO2102"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"award":["01EO2102"],"award-info":[{"award-number":["01EO2102"]}],"id":[{"id":"https:\/\/ror.org\/04pz7b180","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"French National Research Agency","doi-asserted-by":"crossref","award":["ANR-21-RHUS-0012"],"award-info":[{"award-number":["ANR-21-RHUS-0012"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"crossref"}]},{"award":["ANR-21-RHUS-0012"],"award-info":[{"award-number":["ANR-21-RHUS-0012"]}],"id":[{"id":"https:\/\/ror.org\/00rbzpz17","id-type":"ROR","asserted-by":"publisher"}]},{"name":"integrated cancer research center","award":["INCa-DGOS-INSERM-ITMO Cancer_18008"],"award-info":[{"award-number":["INCa-DGOS-INSERM-ITMO Cancer_18008"]}]},{"award":["INCa-DGOS-INSERM-ITMO Cancer_18008"],"award-info":[{"award-number":["INCa-DGOS-INSERM-ITMO Cancer_18008"]}],"id":[{"id":"https:\/\/ror.org\/04rxrdv16","id-type":"ROR","asserted-by":"publisher"}]},{"name":"French FHU","award":["MOSAIC2"],"award-info":[{"award-number":["MOSAIC2"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Myocardial and aortic stiffness are increasingly recognized as clinically relevant biomarkers for cardiovascular disease, yet their noninvasive quantification remains challenging. Magnetic resonance elastography (MRE) has emerged as a promising technique for the spatial mapping of tissue biomechanics by visualizing and analyzing propagating shear waves. This narrative review summarizes the current state of cardiovascular MRE, spanning technical developments in wave generation (acoustic, electromagnetic, gravitational, and transducer-free approaches), pulse sequence design (echo-planar imaging, gradient-recalled echo, spiral, and free-breathing three-dimensional acquisitions), and inversion algorithms (local frequency estimation, direct inversion, finite element methods, and multifrequency elastography). We present evidence from phantom validation, animal models (myocardial infarction, hypertension, right ventricular hypertrophy), and human studies encompassing cardiac amyloidosis, hypertrophic cardiomyopathy, diastolic dysfunction, and abdominal aortic aneurysm. Additionally, we discuss current challenges, including waveguide effects, standardization needs, and clinical translation barriers, and highlight emerging solutions through artificial intelligence, multifrequency methods, and transducer-free cardiac MRE.<\/jats:p>","DOI":"10.3390\/diagnostics16142233","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:55:59Z","timestamp":1784249759000},"page":"2233","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiovascular Magnetic Resonance Elastography: Current Evidence, Challenges, and Future Perspectives"],"prefix":"10.3390","volume":"16","author":[{"given":"Alexander","family":"Wollandt","sequence":"first","affiliation":[{"name":"Clinic for Radiology and Nuclear Medicine, University Hospital, Goethe University Frankfurt, 60590 Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7959-5008","authenticated-orcid":false,"given":"Leon D.","family":"Gruenewald","sequence":"additional","affiliation":[{"name":"Clinic for Radiology and Nuclear Medicine, University Hospital, Goethe University Frankfurt, 60590 Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Booz","sequence":"additional","affiliation":[{"name":"Clinic for Radiology and Nuclear Medicine, University Hospital, Goethe University Frankfurt, 60590 Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0524-6574","authenticated-orcid":false,"given":"Jennifer","family":"Gotta","sequence":"additional","affiliation":[{"name":"Clinic for Radiology and Nuclear Medicine, University Hospital, Goethe University Frankfurt, 60590 Frankfurt am Main, 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Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5218-1075","authenticated-orcid":false,"given":"Thomas J.","family":"Vogl","sequence":"additional","affiliation":[{"name":"Clinic for Radiology and Nuclear Medicine, University Hospital, Goethe University Frankfurt, 60590 Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3100-2167","authenticated-orcid":false,"given":"Sebastian","family":"Haberkorn","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Frankfurt, 60590 Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Ochs","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Frankfurt, 60590 Frankfurt am Main, 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Biomed. Eng."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.yjmcc.2009.08.003","article-title":"Contribution of extracellular matrix to the mechanical properties of the heart","volume":"48","author":"Fomovsky","year":"2010","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1038\/s41598-020-79231-z","article-title":"Shear wave cardiovascular MR elastography using intrinsic cardiac motion for transducer-free non-invasive evaluation of myocardial shear wave velocity","volume":"11","author":"Troelstra","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.yjmcc.2010.06.006","article-title":"Normal passive viscoelasticity but abnormal myofibrillar force generation in human hypertrophic cardiomyopathy","volume":"49","author":"Hoskins","year":"2010","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"H1849","DOI":"10.1152\/ajpheart.00384.2002","article-title":"Pressure overload alters stress-strain properties of the developing chick heart","volume":"285","author":"Miller","year":"2003","journal-title":"Am. J. Physiol.-Heart Circ. Physiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1056\/NEJMoa032566","article-title":"Diastolic heart failure-abnormalities in active relaxation and passive stiffness of the left ventricle","volume":"350","author":"Zile","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1161\/01.CIR.0000129311.73402.EF","article-title":"Ultrasound strain imaging of altered myocardial stiffness: Stunned versus infarcted reperfused myocardium","volume":"109","author":"Pislaru","year":"2004","journal-title":"Circulation"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.jcmg.2018.02.002","article-title":"Myocardial Stiffness Evaluation Using Noninvasive Shear Wave Imaging in Healthy and Hypertrophic Cardiomyopathic Adults","volume":"12","author":"Villemain","year":"2019","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1161\/01.CIR.45.1.11","article-title":"Effect of Coronary Artery Disease and Acute Myocardial Infarction on Left Ventricular Compliance in Man","volume":"45","author":"Diamond","year":"1972","journal-title":"Circulation"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/ca.21006","article-title":"Magnetic resonance elastography: A review","volume":"23","author":"Mariappan","year":"2010","journal-title":"Clin. Anat."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/mrm.21636","article-title":"Assessment of liver viscoelasticity using multifrequency MR elastography","volume":"60","author":"Asbach","year":"2008","journal-title":"Magn. Reson. Med. Off. J. Int. Soc. Magn. Reson. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1002\/mrm.22038","article-title":"In vivo MR elastography of the prostate gland using a transurethral actuator","volume":"62","author":"Chopra","year":"2009","journal-title":"Magn. Reson. Med. Off. J. Int. Soc. Magn. Reson. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/1522-2586(200102)13:2<269::AID-JMRI1039>3.0.CO;2-1","article-title":"Magnetic resonance elastography of skeletal muscle","volume":"13","author":"Dresner","year":"2001","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.mri.2004.11.060","article-title":"Viscoelastic shear properties of in vivo breast lesions measured by MR elastography","volume":"23","author":"Sinkus","year":"2005","journal-title":"Magn. Reson. Imaging"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.clinbiomech.2004.11.010","article-title":"Imaging the shear modulus of the heel fat pads","volume":"20","author":"Weaver","year":"2005","journal-title":"Clin. Biomech."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.cgh.2007.06.012","article-title":"Assessment of Hepatic Fibrosis With Magnetic Resonance Elastography","volume":"5","author":"Yin","year":"2007","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1080\/02841850601026401","article-title":"Magnetic resonance elastography of the human brain: A preliminary study","volume":"48","author":"Xu","year":"2007","journal-title":"Acta Radiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"H501","DOI":"10.1152\/ajpheart.00138.2005","article-title":"Assessment of systolic and diastolic ventricular properties via pressure-volume analysis: A guide for clinical, translational, and basic researchers","volume":"289","author":"Burkhoff","year":"2005","journal-title":"Am. J. Physiol.-Heart Circ. Physiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1136\/heartjnl-2013-305471","article-title":"Role of late gadolinium enhancement cardiovascular magnetic resonance in the risk stratification of hypertrophic cardiomyopathy","volume":"100","author":"Ismail","year":"2014","journal-title":"Heart"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e007722","DOI":"10.1161\/CIRCIMAGING.118.007722","article-title":"Absence of Myocardial Fibrosis Predicts Favorable Long-Term Survival in New-Onset Heart Failure","volume":"11","author":"Gulati","year":"2018","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.jcmg.2017.07.022","article-title":"Prognostic Value of Quantitative Stress Perfusion Cardiac Magnetic Resonance","volume":"11","author":"Sammut","year":"2018","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/1532-429X-15-91","article-title":"Standardized cardiovascular magnetic resonance (CMR) protocols 2013 update","volume":"15","author":"Kramer","year":"2013","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12968-017-0327-9","article-title":"Reference ranges for cardiac structure and function using cardiovascular magnetic resonance (CMR) in Caucasians from the UK Biobank population cohort","volume":"19","author":"Petersen","year":"2016","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1055\/s-0041-1735929","article-title":"Simplified Guide to MR Elastography in Early Detection of Hepatic Fibrosis with Case Reports","volume":"31","author":"Kharat","year":"2021","journal-title":"Indian J. Radiol. Imaging"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/mrm.21991","article-title":"MR elastography as a method for the assessment of myocardial stiffness: Comparison with an established pressure-volume model in a left ventricular model of the heart","volume":"62","author":"Kolipaka","year":"2009","journal-title":"Magn. Reson. Med. Off. J. Int. Soc. Magn. Reson. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1002\/jmri.25432","article-title":"In vivo magnetic resonance elastography to estimate left ventricular stiffness in a myocardial infarction induced porcine model","volume":"45","author":"Mazumder","year":"2016","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/mrm.26695","article-title":"Regional assessment of in vivo myocardial stiffness using 3D magnetic resonance elastography in a porcine model of myocardial infarction","volume":"79","author":"Arunachalam","year":"2017","journal-title":"Magn. Reson. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1002\/mrm.25760","article-title":"Measuring age-dependent myocardial stiffness across the cardiac cycle using MR elastography: A reproducibility study","volume":"75","author":"Wassenaar","year":"2015","journal-title":"Magn. Reson. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1016\/j.jcmg.2018.11.029","article-title":"Velocities of Naturally Occurring Myocardial Shear Waves Increase with Age and in Cardiac Amyloidosis","volume":"12","author":"Petrescu","year":"2019","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1109\/TUFFC.2018.2881493","article-title":"Natural shear wave imaging in the human heart: Normal values, feasibility, and reproducibility","volume":"66","author":"Santos","year":"2018","journal-title":"IEEE Trans. Ultrason. Ferroelectr. Freq. Control"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1002\/mrm.28627","article-title":"MR elastography: Principles, guidelines, and terminology","volume":"85","author":"Manduca","year":"2020","journal-title":"Magn. Reson. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"328","DOI":"10.5152\/dir.2018.18186","article-title":"Magnetic resonance elastography: Basic principles, technique, and clinical applications in the liver","volume":"24","author":"Akkaya","year":"2018","journal-title":"Diagn. Interv. Radiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1126\/science.7569924","article-title":"Magnetic Resonance Elastography by Direct Visualization of Propagating Acoustic Strain Waves","volume":"269","author":"Muthupillai","year":"1995","journal-title":"Science"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1002\/jmri.24056","article-title":"MR elastography of the human abdominal aorta: A preliminary study","volume":"38","author":"Xu","year":"2013","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.nicl.2015.12.007","article-title":"Regional brain stiffness changes across the Alzheimer\u2019s disease spectrum","volume":"10","author":"Murphy","year":"2016","journal-title":"NeuroImage Clin."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/mrm.1910360214","article-title":"Magnetic resonance imaging of transverse acoustic strain waves","volume":"36","author":"Muthupillai","year":"1996","journal-title":"Magn. Reson. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1007\/s00261-022-03597-z","article-title":"Magnetic resonance elastography: From invention to standard of care","volume":"47","author":"Ehman","year":"2022","journal-title":"Abdom. Radiol."},{"key":"ref_39","unstructured":"Castelein, J. (2025). Multifrequency Magnetic Resonance Elastography: Novel Applications in Cardiovascular, Renal, and Intervertebral Tissue. [Master\u2019s Thesis, University of Groningen]. [Thesis fully internal (DIV); University of Groningen]."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e3832","DOI":"10.1002\/nbm.3832","article-title":"Soft tissue rheology and its implications for elastography: Challenges and opportunities","volume":"31","author":"Bilston","year":"2017","journal-title":"NMR Biomed."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/jmri.22866","article-title":"MR elastography of the in vivo abdominal aorta: A feasibility study for comparing aortic stiffness between hypertensives and normotensives","volume":"35","author":"Kolipaka","year":"2011","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/mrm.26101","article-title":"In vivo, high-frequency three-dimensional cardiac MR elastography: Feasibility in normal volunteers","volume":"77","author":"Arani","year":"2016","journal-title":"Magn. Reson. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1097\/RLI.0000000000000660","article-title":"In Vivo Aortic Magnetic Resonance Elastography in Abdominal Aortic Aneurysm: A Validation in an Animal Model","volume":"55","author":"Dong","year":"2020","journal-title":"Investig. Radiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1002\/mrm.21878","article-title":"MR elastography of the human heart: Noninvasive assessment of myocardial elasticity changes by shear wave amplitude variations","volume":"61","author":"Sack","year":"2008","journal-title":"Magn. Reson. Med. Off. J. Int. Soc. Magn. Reson. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1532-429X-11-44","article-title":"Cardiac MR Elastography: Comparison with left ventricular pressure measurement","volume":"11","author":"Elgeti","year":"2009","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"045007","DOI":"10.1088\/1361-6560\/aaf9f8","article-title":"A novel magnetic resonance elastography transducer concept based on a rotational eccentric mass: Preliminary experiences with the gravitational transducer","volume":"64","author":"Runge","year":"2018","journal-title":"Phys. Med. Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.media.2017.12.005","article-title":"Robust MR elastography stiffness quantification using a localized divergence free finite element reconstruction","volume":"44","author":"Fovargue","year":"2018","journal-title":"Med. Image Anal."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1097\/RLI.0000000000000952","article-title":"Single Breath-Hold 3-Dimensional Magnetic Resonance Elastography Depicts Liver Fibrosis and Inflammation in Obese Patients","volume":"58","author":"Darwish","year":"2023","journal-title":"Investig. Radiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1097\/RLI.0000000000000654","article-title":"Steady-State Multifrequency Magnetic Resonance Elastography of the Thoracic and Abdominal Human Aorta\u2014Validation and Reference Values","volume":"55","author":"Schaafs","year":"2020","journal-title":"Investig. Radiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1002\/mrm.70007","article-title":"Time-resolved mapping of myocardial stiffness using 2D multifrequency spiral MR elastography with and without external vibration","volume":"94","author":"Anders","year":"2025","journal-title":"Magn. Reson. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1002\/jmri.25678","article-title":"Cardiac MR elastography for quantitative assessment of elevated myocardial stiffness in cardiac amyloidosis","volume":"46","author":"Arani","year":"2017","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1002\/mrm.70212","article-title":"Free-Breathing, 3D Cardiac Magnetic Resonance Elastography for Myocardial Stiffness Mapping","volume":"95","author":"Meyer","year":"2025","journal-title":"Magn. Reson. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1097\/RLI.0b013e3181822085","article-title":"Cardiac Magnetic Resonance Elastography","volume":"43","author":"Elgeti","year":"2008","journal-title":"Investig. Radiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1097\/RLI.0b013e3181ec4b63","article-title":"Cardiac magnetic resonance elastography: Toward the diagnosis of abnormal myocardial relaxation","volume":"45","author":"Elgeti","year":"2010","journal-title":"Investig. Radiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/j.jcmg.2022.01.009","article-title":"Assessment of Myocardial Stiffness in Patients with Left Ventricular Hypertrophy","volume":"15","author":"Burnhope","year":"2022","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"107893","DOI":"10.1016\/j.ultras.2025.107893","article-title":"Assessing myocardial stiffness with transient elastography using catheter-compatible miniature actuator","volume":"160","author":"Morais","year":"2026","journal-title":"Ultrasonics"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s10396-021-01127-w","article-title":"A review of physical and engineering factors potentially affecting shear wave elastography","volume":"48","author":"Nitta","year":"2021","journal-title":"J. Med. Ultrason."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1148\/rg.2017160116","article-title":"Shear-Wave Elastography: Basic Physics and Musculoskeletal Applications","volume":"37","author":"Taljanovic","year":"2017","journal-title":"RadioGraphics"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/mrm.27029","article-title":"Cardiac MR elastography using reduced-FOV, single-shot, spin-echo EPI","volume":"80","author":"Sui","year":"2017","journal-title":"Magn. Reson. Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1002\/mrm.22048","article-title":"Evaluation of a rapid, multiphase MRE sequence in a heart-simulating phantom","volume":"62","author":"Kolipaka","year":"2009","journal-title":"Magn. Reson. Med. Off. J. Int. Soc. Magn. Reson. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1002\/mrm.22467","article-title":"Magnetic resonance elastography as a method for the assessment of effective myocardial stiffness throughout the cardiac cycle","volume":"64","author":"Kolipaka","year":"2010","journal-title":"Magn. Reson. Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1002\/jmri.25423","article-title":"In vivo quantification of myocardial stiffness in hypertensive porcine hearts using MR elastography","volume":"45","author":"Mazumder","year":"2016","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref_63","first-page":"e241087","article-title":"Reproducibility of Cardiac Multifrequency MR Elastography in Assessing Left Ventricular Stiffness and Viscosity","volume":"312","author":"Castelein","year":"2024","journal-title":"Radiology"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.pnmrs.2015.06.001","article-title":"Magnetic resonance elastography (MRE) in cancer: Technique, analysis, and applications","volume":"91","author":"Pepin","year":"2015","journal-title":"Prog. Nucl. Magn. Reson. Spectrosc."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.jvs.2016.03.426","article-title":"Quantification of abdominal aortic aneurysm stiffness using magnetic resonance elastography and its comparison to aneurysm diameter","volume":"64","author":"Kolipaka","year":"2016","journal-title":"J. Vasc. Surg."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e3996","DOI":"10.1002\/nbm.3996","article-title":"Waveguide effects and implications for cardiac magnetic resonance elastography: A finite element study","volume":"31","author":"Manduca","year":"2018","journal-title":"NMR Biomed."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1002\/mrm.24185","article-title":"Vibration-synchronized magnetic resonance imaging for the detection of myocardial elasticity changes","volume":"67","author":"Elgeti","year":"2012","journal-title":"Magn. Reson. Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1002\/jmri.22531","article-title":"In vivo assessment of MR elastography-derived effective end-diastolic myocardial stiffness under different loading conditions","volume":"33","author":"Kolipaka","year":"2011","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/jmri.23616","article-title":"Magnetic resonance elastography as a method to estimate myocardial contractility","volume":"36","author":"Kolipaka","year":"2012","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.mri.2015.10.001","article-title":"Quantification of myocardial stiffness using magnetic resonance elastography in right ventricular hypertrophy: Initial feasibility in dogs","volume":"34","author":"Scansen","year":"2016","journal-title":"Magn. Reson. Imaging"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1002\/mrm.26030","article-title":"Cardiac MR elastography of the mouse: Initial results","volume":"76","author":"Liu","year":"2016","journal-title":"Magn. Reson. Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"e230140","DOI":"10.1148\/ryct.230140","article-title":"Sex Differences in Aging-Related Myocardial Stiffening Quantitatively Measured with MR Elastography","volume":"6","author":"Arani","year":"2024","journal-title":"Radiol. Cardiothorac. Imaging"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1080\/13506129.2017.1278689","article-title":"Feasibility study of cardiac magnetic resonance elastography in cardiac amyloidosis","volume":"24","author":"Chang","year":"2017","journal-title":"Amyloid"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"e259","DOI":"10.1093\/ehjci\/jeae180","article-title":"Cardiac magnetic resonance elastography imaging in hypertrophic cardiomyopathy","volume":"25","author":"Zhao","year":"2024","journal-title":"Eur. Heart J.-Cardiovasc. Imaging"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1148\/radiol.13131605","article-title":"Shear-wave amplitudes measured with cardiac MR elastography for diagnosis of diastolic dysfunction","volume":"271","author":"Elgeti","year":"2014","journal-title":"Radiology"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.echo.2024.11.009","article-title":"Cardiac Elastography with External Vibration for Quantification of Diastolic Myocardial Stiffness","volume":"38","author":"Meyer","year":"2025","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1002\/jmri.70015","article-title":"Cardiac Magnetic Resonance Elastography: Why Multiplex Approaches Hold the Key to Clinical Translation","volume":"62","author":"Castelein","year":"2025","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.mri.2015.10.011","article-title":"Quantification of regional aortic stiffness using MR elastography: A phantom and ex-vivo porcine aorta study","volume":"34","author":"Zhang","year":"2016","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/mrm.20991","article-title":"Vascular wall elasticity measurement by magnetic resonance imaging","volume":"56","author":"Woodrum","year":"2006","journal-title":"Magn. Reson. Med. Off. J. Int. Soc. Magn. Reson. Med."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.mri.2011.09.009","article-title":"Assessment of stiffness changes in the ex vivo porcine aortic wall using magnetic resonance elastography","volume":"30","author":"Xu","year":"2012","journal-title":"Magn. Reson. Imaging"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1540-8175.2010.01241.x","article-title":"Assessment of aortic stiffness in marfan syndrome using two-dimensional and Doppler echocardiography","volume":"28","author":"Kiotsekoglou","year":"2011","journal-title":"Echocardiography"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.regpep.2012.08.014","article-title":"Arterial stiffness and novel biomarkers in patients with abdominal aortic aneurysms","volume":"179","author":"Kadoglou","year":"2012","journal-title":"Regul. Pept."},{"key":"ref_83","first-page":"353","article-title":"Arterial stiffness, hypertension, and rational use of nebivolol","volume":"5","author":"Porteri","year":"2009","journal-title":"Vasc. Health Risk Manag."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/jmri.21702","article-title":"Phase-contrast MRI-based elastography technique detects early hypertensive changes in Ex vivo porcine aortic wall","volume":"29","author":"Woodrum","year":"2009","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/jmri.24506","article-title":"Quantification of aortic stiffness using MR elastography and its comparison to MRI-based pulse wave velocity","volume":"41","author":"Damughatla","year":"2013","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1002\/mrm.25719","article-title":"Quantification of aortic stiffness using magnetic resonance elastography: Measurement reproducibility, pulse wave velocity comparison, changes over cardiac cycle, and relationship with age","volume":"75","author":"Kenyhercz","year":"2015","journal-title":"Magn. Reson. Med."},{"key":"ref_87","first-page":"e4447","article-title":"Magnetic resonance elastography for estimating in vivo stiffness of the abdominal aorta using cardiac-gated spin-echo echo-planar imaging: A feasibility study","volume":"34","author":"Dong","year":"2020","journal-title":"NMR Biomed."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1148\/radiol.212323","article-title":"MR Elastography of Abdominal Aortic Aneurysms: Relationship to Aneurysm Events","volume":"304","author":"Dong","year":"2022","journal-title":"Radiology"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.actbio.2021.11.026","article-title":"Microscopic multifrequency magnetic resonance elastography of ex vivo abdominal aortic aneurysms for extracellular matrix imaging in a mouse model","volume":"140","author":"Mangarova","year":"2022","journal-title":"Acta Biomater."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jmr.2018.01.004","article-title":"Pre-clinical MR elastography: Principles, techniques, and applications","volume":"291","author":"Bayly","year":"2018","journal-title":"J. Magn. Reson."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"02TR01","DOI":"10.1088\/1361-6560\/ac404d","article-title":"Assessing cardiac stiffness using ultrasound shear wave elastography","volume":"67","author":"Caenen","year":"2022","journal-title":"Phys. Med. Biol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s12968-017-0389-8","article-title":"Clinical recommendations for cardiovascular magnetic resonance mapping of T1, T2, T2* and extracellular volume: A consensus statement by the Society for Cardiovascular Magnetic Resonance (SCMR) endorsed by the European Association for Cardiovascular Imaging (EACVI)","volume":"19","author":"Messroghli","year":"2017","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ehjci\/jeu184","article-title":"Definitions for a common standard for 2D speckle tracking echocardiography: Consensus document of the EACVI\/ASE\/Industry Task Force to standardize deformation imaging","volume":"16","author":"Voigt","year":"2015","journal-title":"Eur. Heart J.-Cardiovasc. Imaging"},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Chen, Y., Zhang, X., Huo, Y., and Wang, S. (2025). Deep Learning-Based Estimation of Myocardial Material Parameters from Cardiac MRI. 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