{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T09:05:37Z","timestamp":1784624737382,"version":"3.55.0"},"reference-count":9,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>A 56-year-old patient was initially diagnosed with aseptic loosening of a left acetabular prosthesis based on 68Ga-FAPI. Half a year after revision, this patient developed right hip pain and a subsequent 68Ga-FAPI was performed revealing increased tracer uptake in the right hip, leading to a diagnosis of synovitis-induced osteoarthritis. This case highlights the utility of 68Ga-FAPI-PET\/CT in visualizing synovial activity and underscores the potential role of synovitis in the pathogenesis of osteoarthritis.<\/jats:p>","DOI":"10.3390\/diagnostics16142278","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T08:14:27Z","timestamp":1784621667000},"page":"2278","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hip Osteoarthritis Associated with Prominent Synovitis Revealed by 68Ga-FAPI PET\/CT"],"prefix":"10.3390","volume":"16","author":[{"given":"Yiqun","family":"Wang","sequence":"first","affiliation":[{"name":"Orthopaedic and Sports Medicine Center, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing 100000, China"},{"name":"Department of Nuclear Medicine, The First Medical Centre, Chinese PLA General Hospital, Beijing 100000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9948-2633","authenticated-orcid":false,"given":"Ruimin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, The First Medical Centre, Chinese PLA General Hospital, Beijing 100000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"La","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine, Peking University Third Hospital, Institute of Sports Medicine of Peking University, Beijing Key Laboratory of Sports Injuries, Beijing 100000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Rong","sequence":"additional","affiliation":[{"name":"Orthopaedic and Sports Medicine Center, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing 100000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ligong","family":"Fu","sequence":"additional","affiliation":[{"name":"Orthopaedic and Sports Medicine Center, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing 100000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1007\/s00259-023-06146-y","article-title":"Diagnostic efficiency of [68 Ga]Ga-DOTA-FAPI-04 in differentiating periprosthetic hip joint infection and aseptic failure","volume":"50","author":"Wang","year":"2023","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/S0140-6736(19)30417-9","article-title":"Osteoarthritis","volume":"393","author":"Hunter","year":"2019","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1056\/NEJMcp071112","article-title":"Clinical practice. Osteoarthritis of the hip","volume":"357","author":"Lane","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/nrrheum.2017.160","article-title":"Therapy: Are you managing osteoarthritis appropriately?","volume":"13","author":"Hunter","year":"2017","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_5","first-page":"65","article-title":"The role of the immune microenvironment in bone, cartilage, and soft tissue regeneration: From mechanism to therapeutic opportunity","volume":"9","author":"Xiong","year":"2022","journal-title":"Mil. Med. Res."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Lv, Z., Yang, Y.X., Li, J., Fei, Y., Guo, H., Sun, Z., Lu, J., Xu, X., Jiang, Q., and Ikegawa, S. (2021). Molecular Classification of Knee Osteoarthritis. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.725568"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41572-025-00594-6","article-title":"Osteoarthritis","volume":"11","author":"Tang","year":"2025","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41413-022-00243-8","article-title":"Inhibition of fibroblast activation protein ameliorates cartilage matrix degradation and osteoarthritis progression","volume":"11","author":"Fan","year":"2023","journal-title":"Bone Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/s41586-019-1263-7","article-title":"Distinct fibroblast subsets drive inflammation and damage in arthritis","volume":"570","author":"Croft","year":"2019","journal-title":"Nature"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/14\/2278\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T08:36:41Z","timestamp":1784623001000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/14\/2278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,21]]},"references-count":9,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["diagnostics16142278"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics16142278","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,21]]}}}