{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T11:03:33Z","timestamp":1784891013447,"version":"3.55.0"},"reference-count":24,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: Computed tomography (CT) is the gold-standard diagnostic modality for acute diverticulitis, yet the association between early CT imaging and short-term clinical outcomes among hospitalized older adults has not been evaluated in a large multicenter propensity-matched cohort. We assessed whether early CT abdomen\/pelvis (within 24 h of admission) was associated with improved short-term outcomes compared with delayed or absent CT among adults aged \u226565 years hospitalized with acute diverticulitis. Methods: We conducted a retrospective cohort study using the TriNetX US Collaborative Research Network through February 2026. Early CT was defined as CT abdomen\/pelvis performed within 24 h of the index hospitalization. Patients underwent 1:1 propensity score matching using demographic, comorbidity, diverticulitis-related, medication, and laboratory variables. The primary outcome was 30-day all-cause mortality. Results: Among 86,214 eligible patients, 62,478 received early CT and 23,736 did not. After matching, 22,840 patients remained in each cohort. Early CT was associated with lower 30-day mortality (RR 0.72, 95% CI 0.62\u20130.84), 90-day mortality (RR 0.78, 95% CI 0.70\u20130.87), bowel surgery within 30 days (RR 0.81, 95% CI 0.73\u20130.90), sepsis (RR 0.76, 95% CI 0.69\u20130.84), acute kidney injury (RR 0.85, 95% CI 0.78\u20130.92), ICU admission (RR 0.79, 95% CI 0.72\u20130.87), and 30-day readmission (RR 0.86, 95% CI 0.80\u20130.93). Early CT was also associated with higher rates of percutaneous abscess drainage (RR 1.37, 95% CI 1.21\u20131.55) and shorter hospital length of stay (5.4 vs. 6.8 days; mean difference \u22121.4 days, 95% CI \u22121.6 to \u22121.2). Conclusions: Early CT imaging within 24 h of admission was associated with improved short-term outcomes among older adults hospitalized with acute diverticulitis, including lower mortality, reduced need for bowel surgery, lower rates of sepsis and acute kidney injury, shorter hospital stay, and higher utilization of percutaneous abscess drainage. These findings support guideline recommendations for prompt diagnostic CT imaging in this population and suggest that early CT may facilitate timely risk stratification, source control, and management optimization.<\/jats:p>","DOI":"10.3390\/diagnostics16152322","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T10:38:41Z","timestamp":1784889521000},"page":"2322","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early Computed Tomography Imaging and Clinical Outcomes in Hospitalized Patients with Acute Diverticulitis: A Propensity-Matched Multicenter Cohort Study"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5277-2884","authenticated-orcid":false,"given":"Noor","family":"Albusta","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Lahey Hospital and Medical Center, Burlington, MA 01805, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Bosta","sequence":"additional","affiliation":[{"name":"Medical Department, Salmaniya Medical Complex, Manama P.O. Box 12, Bahrain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussain","family":"Alrahma","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Salmaniya Medical Complex, Manama P.O. Box 12, Bahrain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1097\/DCR.0000000000001679","article-title":"Prepared on behalf of the Clinical Practice Guidelines Committee of the American Society of Colon and Rectal Surgeons. The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Treatment of Left-Sided Colonic Diverticulitis","volume":"63","author":"Hall","year":"2020","journal-title":"Dis. Colon Rectum"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1053\/j.gastro.2015.10.003","article-title":"American Gastroenterological Association Institute Guideline on the Management of Acute Diverticulitis","volume":"149","author":"Stollman","year":"2015","journal-title":"Gastroenterology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"S141","DOI":"10.1016\/j.jacr.2019.02.015","article-title":"ACR Appropriateness Criteria\u00ae Left Lower Quadrant Pain\u2014Suspected Diverticulitis","volume":"16","author":"Galgano","year":"2019","journal-title":"J. Am. Coll. Radiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1056\/NEJMcp1800468","article-title":"Diverticulitis","volume":"379","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1056\/NEJMcp073228","article-title":"Diverticulitis","volume":"357","author":"Jacobs","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1148\/radiol.12121460","article-title":"Frequency of Acute Kidney Injury Following Intravenous Contrast Medium Administration: A Systematic Review and Meta-Analysis","volume":"267","author":"McDonald","year":"2013","journal-title":"Radiology"},{"key":"ref_7","first-page":"1546","article-title":"Diverticulitis","volume":"333","author":"Brown","year":"2025","journal-title":"JAMA"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"b2431","DOI":"10.1136\/bmj.b2431","article-title":"Imaging Strategies for Detection of Urgent Conditions in Patients with Acute Abdominal Pain: Diagnostic Accuracy Study","volume":"338","author":"Bouma","year":"2009","journal-title":"BMJ"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1148\/radiol.2019192094","article-title":"Use of Intravenous Iodinated Contrast Media in Patients with Kidney Disease: Consensus Statements from the American College of Radiology and the National Kidney Foundation","volume":"294","author":"Davenport","year":"2020","journal-title":"Radiology"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Ludwig, R.J., Anson, M., Zirpel, H., Thaci, D., Olbrich, H., Bieber, K., Kridin, K., Dempfle, A., Curman, P., and Zhao, S.S. (2025). A Comprehensive Review of Methodologies and Application to Use the Real-World Data and Analytics Platform TriNetX. Front. Pharmacol., 16.","DOI":"10.3389\/fphar.2025.1516126"},{"key":"ref_11","unstructured":"OPTIMA Study Group (2009). Randomized Comparison of Routine versus Selective Use of CT for Acute Abdominal Pain. Br. J. Surg., 96, 1002\u20131008."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/bjs.7723","article-title":"Italian Study Group on Complicated Diverticulosis. Multicentre Observational Study of the Natural History of Left-Sided Acute Diverticulitis","volume":"99","author":"Binda","year":"2012","journal-title":"Br. J. Surg."},{"key":"ref_13","first-page":"831","article-title":"Effect of the 2017 ASCRS Guidelines on Treatment of Acute Diverticulitis","volume":"63","author":"Cologne","year":"2020","journal-title":"Dis. Colon Rectum"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1007\/s10350-004-6335-5","article-title":"Prevalence of Perforated Sigmoid Diverticulitis Is Increasing","volume":"45","author":"Kiviniemi","year":"2002","journal-title":"Dis. Colon Rectum"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1053\/j.gastro.2020.09.059","article-title":"AGA Clinical Practice Update on Medical Management of Colonic Diverticulitis: Expert Review","volume":"160","author":"Peery","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"399","DOI":"10.7326\/M21-2710","article-title":"Clinical Guidelines Committee of the American College of Physicians. Diagnosis and Management of Acute Left-Sided Colonic Diverticulitis: A Clinical Guideline From the American College of Physicians","volume":"175","author":"Qaseem","year":"2022","journal-title":"Ann. Intern. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"379","DOI":"10.7326\/M21-1645","article-title":"Diagnostic Imaging and Medical Management of Acute Left-Sided Colonic Diverticulitis: A Systematic Review","volume":"175","author":"Balk","year":"2022","journal-title":"Ann. Intern. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13017-022-00408-0","article-title":"The WSES\/SICG\/ACOI\/SICUT\/AcEMC\/SIFIPAC Guidelines for Diagnosis and Treatment of Acute Left Colonic Diverticulitis in the Elderly","volume":"17","author":"Fugazzola","year":"2022","journal-title":"World J. Emerg. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"S109","DOI":"10.1093\/cid\/ciae350","article-title":"2024 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Complicated Intra-Abdominal Infections: Diagnostic Imaging of Suspected Acute Diverticulitis in Adults and Pregnant People","volume":"79","author":"Bonomo","year":"2024","journal-title":"Clin. Infect. Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/fampra\/cmad118","article-title":"Accuracy of Diagnostic Tests for Acute Diverticulitis That Are Feasible in Primary Care: A Systematic Review and Meta-Analysis","volume":"41","author":"Vijfschagt","year":"2024","journal-title":"Fam. Pract."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Cirocchi, R., Randolph, J., Panata, L., Davies, R.J., Tarchi, P., Sileri, P., Di Saverio, S., Ceresoli, M., Coccolini, F., and Henry, B.M. (2023). Guidelines for the Treatment of Abdominal Abscesses in Acute Diverticulitis: An Umbrella Review. J. Clin. Med., 12.","DOI":"10.20944\/preprints202307.0269.v1"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00384-024-04618-7","article-title":"Systematic Review and Meta-Analysis of the Management of Acute Uncomplicated Diverticulitis: Time to Change Traditional Practice","volume":"39","author":"Mohamedahmed","year":"2024","journal-title":"Int. J. Color. Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1055\/s-0043-1777439","article-title":"Diverticulitis: A Review of Current and Emerging Practice-Changing Evidence","volume":"37","author":"Wu","year":"2024","journal-title":"Clin. Colon Rectal Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1111\/jgs.19388","article-title":"Diverticulitis in Older Adults: A Review of Etiology, Diagnosis, and Management","volume":"73","author":"Hall","year":"2025","journal-title":"J. Am. Geriatr. Soc."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/15\/2322\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T10:53:42Z","timestamp":1784890422000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/15\/2322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,24]]},"references-count":24,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["diagnostics16152322"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics16152322","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,24]]}}}