{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T09:02:20Z","timestamp":1785229340299,"version":"3.55.0"},"reference-count":71,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>High-resolution micro-ultrasound (microUS) is a 29 MHz imaging modality that allows visualisation of prostatic ductal architecture at 70 \u00b5m resolution, enabling real-time recognition of architectural disruption associated with clinically significant prostate cancer (csPCa). This review summarises the current evidence for microUS in the diagnosis and management of prostate cancer, with emphasis on developments since the pivotal OPTIMUM phase-3 randomised controlled trial. OPTIMUM provided level 1 evidence for microUS-guided biopsy as non-inferior to MRI-guided biopsy for csPCa detection. We examine the PRI-MUS risk identification protocol, the pre- and post-OPTIMUM evidence base, biopsy targeting and core number, inter-observer reliability and the learning curve, and emerging applications in active surveillance, restaging biopsy, local staging and tumour characterisation, and post-treatment surveillance for local recurrence. We also review the growing body of work on artificial intelligence-enhanced microUS, alongside workflow, cost, and environmental considerations. Whilst inter-reader variability and the learning curve remain barriers, microUS offers comparable sensitivity to multiparametric MRI with practical advantages in cost, accessibility, and workflow. In our view, microUS warrants acceptance as a primary imaging modality for the work-up of suspected prostate cancer.<\/jats:p>","DOI":"10.3390\/diagnostics16152364","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T07:55:41Z","timestamp":1785225341000},"page":"2364","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["From Detection to Surveillance: The Evolving Role of Micro-Ultrasound in Prostate Cancer"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6466-5536","authenticated-orcid":false,"given":"Darius","family":"Ashrafi","sequence":"first","affiliation":[{"name":"Division of Urology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON M4N 3M5, Canada"},{"name":"Surgical Outcomes Research Centre (SOuRCe), Royal Prince Alfred Hospital, Sydney, NSW 2050, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Klotz","sequence":"additional","affiliation":[{"name":"Division of Urology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON M4N 3M5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1016\/S0140-6736(24)00651-2","article-title":"The Lancet Commission on prostate cancer: Planning for the surge in cases","volume":"403","author":"James","year":"2024","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1259\/bjr\/56357549","article-title":"Applications of transrectal ultrasound in prostate cancer","volume":"85","author":"Harvey","year":"2012","journal-title":"Br. J. Radiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"384","DOI":"10.2214\/AJR.18.20796","article-title":"The Evolution of MRI of the Prostate: The Past, the Present, and the Future","volume":"213","author":"Giganti","year":"2019","journal-title":"Am. J. Roentgenol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S0140-6736(16)32401-1","article-title":"Diagnostic accuracy of multi-parametric MRI and TRUS biopsy in prostate cancer (PROMIS): A paired validating confirmatory study","volume":"389","author":"Ahmed","year":"2017","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1056\/NEJMoa1801993","article-title":"MRI-Targeted or Standard Biopsy for Prostate-Cancer Diagnosis","volume":"378","author":"Kasivisvanathan","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.eururo.2024.03.027","article-title":"EAU-EANM-ESTRO-ESUR-ISUP-SIOG Guidelines on Prostate Cancer-2024 Update. Part I: Screening, Diagnosis, and Local Treatment with Curative Intent","volume":"86","author":"Cornford","year":"2024","journal-title":"Eur. Urol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1007\/s00261-025-05207-0","article-title":"Evaluating the impact of reader experience on PI-RADS 3 of version 2.1 scoring concordance in multiparametric prostate MRI: A single-center analysis","volume":"51","author":"He","year":"2026","journal-title":"Abdom. Radiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"396.e1","DOI":"10.1016\/j.urolonc.2024.10.002","article-title":"Inter-reader reliability and diagnostic accuracy of PI-RADS scoring between academic and community care networks: How wide is the gap?","volume":"43","author":"Smani","year":"2025","journal-title":"Urol. Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1007\/s00330-023-10345-4","article-title":"Decreased prostate MRI cancer detection rate due to moderate to severe susceptibility artifacts from hip prosthesis","volume":"34","author":"Nakai","year":"2024","journal-title":"Eur. Radiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1001\/jama.2025.13722","article-title":"Biparametric vs Multiparametric MRI for Prostate Cancer Diagnosis: The PRIME Diagnostic Clinical Trial","volume":"334","author":"Ng","year":"2025","journal-title":"JAMA"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/S1470-2045(22)00016-X","article-title":"Multiparametric ultrasound versus multiparametric MRI to diagnose prostate cancer (CADMUS): A prospective, multicentre, paired-cohort, confirmatory study","volume":"23","author":"Grey","year":"2022","journal-title":"Lancet Oncol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1001\/jamaoncol.2020.7589","article-title":"Comparison of Multiparametric Magnetic Resonance Imaging-Targeted Biopsy with Systematic Transrectal Ultrasonography Biopsy for Biopsy-Naive Men at Risk for Prostate Cancer: A Phase 3 Randomized Clinical Trial","volume":"7","author":"Klotz","year":"2021","journal-title":"JAMA Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"34.e27","DOI":"10.1016\/j.urolonc.2013.01.006","article-title":"High-resolution transrectal ultrasound: Pilot study of a novel technique for imaging clinically localized prostate cancer","volume":"32","author":"Pavlovich","year":"2014","journal-title":"Urol. Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.juro.2015.12.093","article-title":"Assessing Cancer Risk on Novel 29 MHz Micro-Ultrasound Images of the Prostate: Creation of the Micro-Ultrasound Protocol for Prostate Risk Identification","volume":"196","author":"Ghai","year":"2016","journal-title":"J. Urol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1001\/jama.2025.3579","article-title":"Microultrasonography-Guided vs MRI-Guided Biopsy for Prostate Cancer Diagnosis: The OPTIMUM Randomized Clinical Trial","volume":"333","author":"Kinnaird","year":"2025","journal-title":"JAMA"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"21","DOI":"10.5489\/cuaj.9607","article-title":"Micro-ultrasound in the Canadian prostate cancer diagnostic pathway","volume":"20","author":"Millan","year":"2026","journal-title":"Can. Urol. Assoc. J."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Garcia-Becerra, C.A., Arias-Gallardo, M.I., Juarez-Garcia, J.E., Soltero-Molinar, V., El Rassi, A.J., Rivera-Rocha, M.I., Parra-Camano, L.F., Ruiz, M., Garcia-Becerra, N., and Cordeiro, M.D. (2026). Comparative diagnostic accuracy of multiparametric-MRI and Micro-ultrasound for clinically significant prostate cancer-a bivariate meta-analysis of prospective studies. Prostate Cancer Prostatic Dis.","DOI":"10.1038\/s41391-026-01079-7"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Wendler, J.J., Bechstein, J., Buckendahl, J., Kruck, S., Samtleben, C., Liehr, B.U., Porsch, M., and Cash, H. (2026). The value of micro-ultrasound for prostate cancer screening: A retrospective real-world feasibility study. Prostate Cancer Prostatic Dis.","DOI":"10.1038\/s41391-026-01075-x"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"101639","DOI":"10.1016\/j.conctc.2026.101639","article-title":"Micro-UltraSound In Cancer-Active Surveillance (MUSIC-AS): A paired, prospective, non-inferiority trial comparing micro-ultrasound and multiparametric MRI at confirmatory biopsy","volume":"51","author":"Little","year":"2026","journal-title":"Contemp. Clin. Trials Commun."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/pros.70069","article-title":"Diagnostic Value of Micro-Ultrasound in Identifying Local Recurrence After Radical Prostatectomy","volume":"86","author":"Kaufmann","year":"2026","journal-title":"Prostate"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e70133","DOI":"10.1002\/bco2.70133","article-title":"AI-enhanced micro-ultrasound improves detection of clinically significant prostate cancer at biopsy","volume":"7","author":"Imran","year":"2026","journal-title":"BJUI Compass"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1001\/jama.2025.7941","article-title":"Microultrasonography-Guided vs MRI-Guided Biopsy for Prostate Cancer Diagnosis","volume":"334","author":"Catto","year":"2025","journal-title":"JAMA"},{"key":"ref_23","first-page":"15","article-title":"Micro-ultrasound transperineal prostate biopsy as an alternative to MRI-US fusion transrectal biopsy","volume":"20","author":"Black","year":"2026","journal-title":"Can. Urol. Assoc. J."},{"key":"ref_24","unstructured":"Exact Imaging (2026, June 03). PRI-MUS Risk Identification Protocol. Available online: https:\/\/www.exactimaging.com\/primus-protocol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.1007\/s00345-023-04591-w","article-title":"Assessing cancer risk in the anterior part of the prostate using micro-ultrasound: Validation of a novel distinct protocol","volume":"41","author":"Schaer","year":"2023","journal-title":"World J. Urol."},{"key":"ref_26","unstructured":"Exact Imaging (2026, June 03). PRI-MUS Anterior Quick Reference Poster. Available online: https:\/\/www.exactimaging.com\/images\/manuals\/English\/PN%207067%20EI%20PRI-MUS%20V2%20Anterior%20EN%20Rev%201.2.pdf."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e70192","DOI":"10.1002\/bco2.70192","article-title":"Micro-ultrasound tissue echogenicity predicts prostate cancer grade","volume":"7","author":"Corona","year":"2026","journal-title":"BJUI Compass"},{"key":"ref_28","first-page":"E11","article-title":"Comparison of micro-ultrasound and multiparametric magnetic resonance imaging for prostate cancer: A multicenter, prospective analysis","volume":"15","author":"Klotz","year":"2021","journal-title":"Can. Urol. Assoc. J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.euf.2020.09.013","article-title":"Diagnostic Accuracy of Microultrasound in Patients with a Suspicion of Prostate Cancer at Magnetic Resonance Imaging: A Single-institutional Prospective Study","volume":"7","author":"Lughezzani","year":"2021","journal-title":"Eur. Urol. Focus"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/bju.15635","article-title":"A non-inferiority comparative analysis of micro-ultrasonography and MRI-targeted biopsy in men at risk of prostate cancer","volume":"129","author":"Hofbauer","year":"2022","journal-title":"BJU Int."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"832.e1","DOI":"10.1016\/j.urolonc.2021.05.030","article-title":"The use of 29 MHz transrectal micro-ultrasound to stratify the prostate cancer risk in patients with PI-RADS III lesions at multiparametric MRI: A single institutional analysis","volume":"39","author":"Avolio","year":"2021","journal-title":"Urol. Oncol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"208","DOI":"10.5489\/cuaj.8626","article-title":"Micro-ultrasound for the detection of clinically significant prostate cancer in biopsy-naive men with negative MRI","volume":"18","author":"Albers","year":"2024","journal-title":"Can. Urol. Assoc. J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.euros.2022.11.015","article-title":"Assessing the Role of High-resolution Microultrasound Among Naive Patients with Negative Multiparametric Magnetic Resonance Imaging and a Persistently High Suspicion of Prostate Cancer","volume":"47","author":"Avolio","year":"2023","journal-title":"Eur. Urol. Open Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/JU.0000000000004793","article-title":"Detection of Clinically Significant Prostate Cancer Using Micro-Ultrasound vs Magnetic Resonance Imaging\/Ultrasound Fusion Biopsy: A Propensity-Weighted Comparative Study","volume":"215","author":"Dias","year":"2026","journal-title":"J. Urol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"69.e11","DOI":"10.1016\/j.urolonc.2025.08.018","article-title":"Microultrasound-targeted biopsies in patients with suspected prostate cancer: Diagnostic accuracy and clinical utility","volume":"44","author":"Carvajal","year":"2026","journal-title":"Urol. Oncol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3408","DOI":"10.1007\/s00330-025-12136-5","article-title":"Detection of clinically significant prostate cancer using targeted MRI-informed microultrasound biopsy","volume":"36","author":"Forrest","year":"2026","journal-title":"Eur. Radiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"111049","DOI":"10.1016\/j.urolonc.2026.111049","article-title":"Comparison of prostate cancer detection rates between micro-ultrasound-guided and multiparametric magnetic resonance imaging-guided prostate biopsy: A systematic review and meta-analysis of prospective studies","volume":"44","author":"Lu","year":"2026","journal-title":"Urol. Oncol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/bju.70270","article-title":"Micro-ultrasonography- vs MRI-targeted biopsy in prostate cancer: Updated systematic review and meta-analysis","volume":"138","author":"Micheleto","year":"2026","journal-title":"BJU Int."},{"key":"ref_39","first-page":"2979","article-title":"Standalone 29-MHz micro-ultrasound for classifying clinically significant prostate cancer: A systematic review and diagnostic test accuracy meta-analysis of prospective studies","volume":"51","author":"Aboelsaad","year":"2026","journal-title":"Abdom. Radiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.urolonc.2026.05.007","article-title":"Micro-ultrasound as an alternative to MRI in prostate cancer biopsy: Correlation with prostatectomy findings","volume":"44","author":"Furlano","year":"2026","journal-title":"Urol. Oncol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/bju.15556","article-title":"The modified International Society of Urological Pathology system improves concordance between biopsy and prostatectomy tumour grade","volume":"128","author":"Hennes","year":"2021","journal-title":"BJU Int."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"336.e13","DOI":"10.1016\/j.urolonc.2024.10.018","article-title":"Pathologic prostate cancer grade concordance among high-resolution micro-ultrasound, systematic transrectal ultrasound and MRI fusion biopsy","volume":"43","author":"Lokeshwar","year":"2025","journal-title":"Urol. Oncol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.eururo.2019.04.008","article-title":"Role of Core Number and Location in Targeted Magnetic Resonance Imaging-Ultrasound Fusion Prostate Biopsy","volume":"76","author":"Lu","year":"2019","journal-title":"Eur. Urol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1097\/JU.0000000000001302","article-title":"How Many Targeted Biopsy Cores are Needed for Clinically Significant Prostate Cancer Detection during Transperineal Magnetic Resonance Imaging Ultrasound Fusion Biopsy?","volume":"204","author":"Song","year":"2020","journal-title":"J. Urol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.urology.2023.11.018","article-title":"Value of Incremental Biopsy Cores for Microultrasound Targeted Prostate Biopsies","volume":"184","author":"Albers","year":"2024","journal-title":"Urology"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1111\/bju.70204","article-title":"Transrectal vs transperineal prostate biopsy: A systematic review and meta-analysis","volume":"137","author":"Calpin","year":"2026","journal-title":"BJU Int."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.euros.2024.06.017","article-title":"Inter-reader Agreement for Prostate Cancer Detection Using Micro-ultrasound: A Multi-institutional Study","volume":"66","author":"Zhou","year":"2024","journal-title":"Eur. Urol. Open Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"62","DOI":"10.48083\/KKVJ7280","article-title":"Prostate Cancer Detection by Novice Micro-Ultrasound Users Enrolled in a Training Program","volume":"3","author":"Cash","year":"2022","journal-title":"Soci\u00e9t\u00e9 Int. D\u2019urologie J."},{"key":"ref_49","first-page":"E70","article-title":"Comparison of conventional transrectal ultrasound, magnetic resonance imaging, and micro-ultrasound for visualizing prostate cancer in an active surveillance population: A feasibility study","volume":"13","author":"Eure","year":"2019","journal-title":"Can. Urol. Assoc. J."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.euros.2022.09.019","article-title":"Micro-ultrasound Versus Magnetic Resonance Imaging in Prostate Cancer Active Surveillance","volume":"46","author":"Albers","year":"2022","journal-title":"Eur. Urol. Open Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.fpurol.2024.12.005","article-title":"Biopsie guid\u00e9e par micro-\u00e9chographie versus biopsie cibl\u00e9e par IRM multiparam\u00e9trique chez les hommes en surveillance active pour un cancer de la prostate","volume":"35","author":"Kissel","year":"2025","journal-title":"Progr\u00e8s Urol.-FMC"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.euros.2020.05.002","article-title":"Use of 29-MHz Micro-ultrasound for Local Staging of Prostate Cancer in Patients Scheduled for Radical Prostatectomy: A Feasibility Study","volume":"19","author":"Regis","year":"2020","journal-title":"Eur. Urol. Open Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s00345-021-03890-4","article-title":"Use of high-resolution micro-ultrasound to predict extraprostatic extension of prostate cancer prior to surgery: A prospective single-institutional study","volume":"40","author":"Fasulo","year":"2022","journal-title":"World J. Urol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"159.e9","DOI":"10.1016\/j.urolonc.2024.01.033","article-title":"Development of a microultrasound-based nomogram to predict extra-prostatic extension in patients with prostate cancer undergoing robot-assisted radical prostatectomy","volume":"42","author":"Frego","year":"2024","journal-title":"Urol. Oncol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1097\/JU.0000000000004069","article-title":"The Genomics and Natural History of MRI-Visible vs MRI-Invisible Prostate Cancers: Clinical Implications","volume":"212","author":"Klotz","year":"2024","journal-title":"J. Urol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e2332900","DOI":"10.1001\/jamanetworkopen.2023.32900","article-title":"Biochemical Recurrence and Risk of Mortality Following Radiotherapy or Radical Prostatectomy","volume":"6","author":"Falagario","year":"2023","journal-title":"JAMA Netw. Open"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"3010","DOI":"10.1007\/s00261-025-05256-5","article-title":"Diagnostic performance of PSMA PET\/CT, multiparametric MRI, and combined imaging for local prostate cancer recurrence after radical prostatectomy","volume":"51","author":"Phillipi","year":"2026","journal-title":"Abdom. Radiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"102326","DOI":"10.1016\/j.compmedimag.2024.102326","article-title":"MicroSegNet: A deep learning approach for prostate segmentation on micro-ultrasound images","volume":"112","author":"Jiang","year":"2024","journal-title":"Comput Med. Imaging Graph"},{"key":"ref_59","unstructured":"Hung, A.L.Y., Zhao, K., Pang, K., Miao, Q., Wang, Z., Brisbane, W., Terzopoulos, D., and Sung, K. (2025, January 14\u201317). Minimally User-Guided 3D Micro-Ultrasound Prostate Segmentation. Proceedings of the 2025 IEEE 22nd International Symposium on Biomedical Imaging (ISBI), Houston, TX, USA."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Al-Qurri, A., Thaher, A., and Almekkawy, M.K. (2025). Enhanced Deep Neural Network for Prostate Segmentation in Micro-Ultrasound Images. Sensors, 25.","DOI":"10.3390\/s25226815"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"18910","DOI":"10.1038\/s41598-024-69804-7","article-title":"Evaluation of prostate cancer detection using micro-ultrasound versus MRI through co-registration to whole-mount pathology","volume":"14","author":"Pensa","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Pang, K., Miao, Q., Hung, A.L.Y., Zhao, K., Oh, E., Ramirez, R., Brisbane, W., and Sung, K. (2025, January 14\u201317). Mpr-Diff: A Self-Supervised Diffusion Model for Multi-Planar Reformation in Prostate Micro-Ultrasound Imaging. Proceedings of the 2025 IEEE 22nd International Symposium on Biomedical Imaging (ISBI), Houston, TX, USA.","DOI":"10.1109\/ISBI60581.2025.10981012"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1007\/s11548-023-02949-4","article-title":"TRUSformer: Improving prostate cancer detection from micro-ultrasound using attention and self-supervision","volume":"18","author":"Gilany","year":"2023","journal-title":"Int. J. Comput. Assist. Radiol. Surg."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1007\/s11548-025-03335-y","article-title":"TRUSWorthy: Toward clinically applicable deep learning for confident detection of prostate cancer in micro-ultrasound","volume":"20","author":"Harmanani","year":"2025","journal-title":"Int. J. Comput. Assist. Radiol. Surg."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s11548-025-03561-4","article-title":"ProstNFound+: A Prospective Study using Medical Foundation Models for Prostate Cancer Detection","volume":"21","author":"Wilson","year":"2026","journal-title":"Int. J. Comput. Assist. Radiol. Surg."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1111\/bju.16892","article-title":"ProMUS-NET: Artificial intelligence detects more prostate cancer than urologists on micro-ultrasonography","volume":"136","author":"Zhou","year":"2025","journal-title":"BJU Int."},{"key":"ref_67","first-page":"e00041","article-title":"Artificial Intelligence\u2013Assisted Prostate Cancer Diagnosis on Transrectal Microultrasound\u2014A Pilot Study for the DeepTRUS Model","volume":"4","author":"Kovacs","year":"2026","journal-title":"JU Open Plus"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Cella, L., Paciotti, M., Avolio, P.P., Fasulo, V., Piccolini, A., Canneto, R., Cavadini, G., Di Stefano, L., Saita, A., and Casale, P. (2026). AI in High-Frequency Micro-Ultrasound: Advancing Prostate Imaging from Segmentation to Cancer Detection. Cancers, 18.","DOI":"10.3390\/cancers18040665"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/bju.15899","article-title":"The rapid assessment for prostate imaging and diagnosis (RAPID) prostate cancer diagnostic pathway","volume":"131","author":"Connor","year":"2023","journal-title":"BJU Int."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jacr.2025.09.013","article-title":"Green Imaging: Scoping Review of Radiology\u2019s Environmental Impact","volume":"23","author":"Woolen","year":"2026","journal-title":"J. Am. Coll. Radiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/pros.24862","article-title":"Optimizing Prostate Cancer Diagnostic Work-Up Through Micro-Ultrasound: Minimizing Unnecessary Procedures and Reducing Overdiagnoses","volume":"85","author":"Beatrici","year":"2025","journal-title":"Prostate"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/15\/2364\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T08:14:27Z","timestamp":1785226467000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/15\/2364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,28]]},"references-count":71,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["diagnostics16152364"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics16152364","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,28]]}}}