{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T09:06:02Z","timestamp":1785229562124,"version":"3.55.0"},"reference-count":39,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research Grants Council Early Careers Scheme, Hong Kong","award":["24106022"],"award-info":[{"award-number":["24106022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: Corpus callosum atrophy is a well recognized feature of multiple sclerosis (MS), which has been associated with disease duration and severity. Quantitative T1rho imaging is an MRI technique sensitive to microstructural tissue alterations, but the T1rho characteristics of the corpus callosum in MS remain largely unexplored. This study aimed to characterize T1rho in the corpus callosum in MS patients, and examine relationships between T1rho values, callosal atrophy, and clinical and imaging markers of disease burden. Method: Thirty patients with relapsing-remitting multiple sclerosis (RRMS) and 30 healthy controls underwent T1rho imaging. T1rho values were measured in the genu, body, splenium, and whole corpus callosum. Comparisons between patient and control groups were performed using the Mann\u2013Whitney U test and the independent samples t-test, and Pearson\u2019s and Spearman\u2019s correlation coefficients were used to evaluate the correlation between imaging and clinical measures. Results: T1rho values were significantly increased across all corpus callosum subregions in patients compared to controls. Corpus callosum T1rho values showed correlations with disease duration (r = 0.375\u20130.408, p &lt; 0.041), lesion load (r = 0.726\u20130.810, p &lt; 0.001), and the corpus callosum index (CCI) (r = \u22120.731\u2013\u22120.640, p &lt; 0.001). Conclusions: T1rho values are elevated in the corpus callosum of MS patients and associated with disease duration, lesion load, and callosal atrophy.<\/jats:p>","DOI":"10.3390\/diagnostics16152368","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T08:52:01Z","timestamp":1785228721000},"page":"2368","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Elevated Corpus Callosum T1rho Reflects Disease Burden and Structural Atrophy in Multiple Sclerosis"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5082-5479","authenticated-orcid":false,"given":"Lei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8268-0721","authenticated-orcid":false,"given":"Tiffany Y.","family":"So","sequence":"additional","affiliation":[{"name":"Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqiang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7242-9285","authenticated-orcid":false,"given":"Weitian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6442-5874","authenticated-orcid":false,"given":"Joseph C. H.","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1155-4389","authenticated-orcid":false,"given":"Qiyong H.","family":"Ai","sequence":"additional","affiliation":[{"name":"Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1270-995X","authenticated-orcid":false,"given":"Queenie","family":"Chan","sequence":"additional","affiliation":[{"name":"Philips Healthcare, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5933-9290","authenticated-orcid":false,"given":"Alexander Y. L.","family":"Lau","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S1474-4422(18)30443-5","article-title":"Global, regional, and national burden of multiple sclerosis 1990\u20132016: A systematic analysis for the Global Burden of Disease Study 2016","volume":"18","author":"Wallin","year":"2019","journal-title":"Lancet Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1111\/ene.15360","article-title":"The contribution of neuropathology to multiple sclerosis research","volume":"29","author":"Lassmann","year":"2022","journal-title":"Eur. J. 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