{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T21:25:28Z","timestamp":1789507528371,"version":"build-2803163510"},"reference-count":72,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Early detection of autism spectrum disorder (ASD) in young children is essential for timely referral, developmental monitoring, and access to early intervention. However, conventional screening and diagnostic pathways often depend on parent-report instruments, episodic clinical observation, and specialist-administered assessments, which may delay identification during the first years of life. This scoping review maps the methodological landscape of early ASD detection from traditional clinical screening to multimodal artificial intelligence (AI). A structured literature search was conducted across major biomedical, psychological, and engineering databases for studies published between January 2010 and May 2026. After screening and eligibility assessment, 65 evidence sources were included in the qualitative synthesis, with additional methodological guidelines used to support reporting and appraisal. The reviewed evidence shows that early ASD detection is increasingly shifting from single-session clinical assessment toward multidimensional risk characterization. Clinical and behavioral screening tools remain the foundation of early identification, while eye tracking, video-based motor analysis, acoustic and vocal biomarkers, electroencephalography (EEG), functional near-infrared spectroscopy (fNIRS), and molecular or genomic indicators provide complementary information across different developmental windows. AI-based methods, including machine learning, deep learning, Transformer architectures, multimodal fusion strategies, and foundation-model-based representation learning, may improve the objective quantification of gaze, movement, vocalization, neural activity, and biological risk. Nevertheless, most AI-assisted systems remain limited by small and heterogeneous datasets, insufficient external validation, population bias, privacy concerns, computational burden, and limited interpretability. This review argues that future early ASD detection systems should be developed as clinician-supervised decision-support tools rather than autonomous diagnostic instruments. Clinically meaningful progress will require robust external validation, privacy-preserving deployment, age-appropriate risk stratification, and intrinsically interpretable architectures that align model outputs with developmental and clinical knowledge.<\/jats:p>","DOI":"10.3390\/diagnostics16152376","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T11:45:26Z","timestamp":1785239126000},"page":"2376","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Early Detection Methods for Autism Spectrum Disorder: From Clinical Screening to Multimodal AI"],"prefix":"10.3390","volume":"16","author":[{"given":"Wenhao","family":"Luo","sequence":"first","affiliation":[{"name":"Institute for Data Engineering and Science, University of Saint Joseph, Estrada Marginal da Ilha Verde, 14\u201317, Macao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5295-4642","authenticated-orcid":false,"given":"Zhiwu","family":"Yin","sequence":"additional","affiliation":[{"name":"Netclass Technology Inc., Shanghai 200436, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1439-7906","authenticated-orcid":false,"given":"Jianbiao","family":"Dai","sequence":"additional","affiliation":[{"name":"Institute for Data Engineering and Science, University of Saint Joseph, Estrada Marginal da Ilha Verde, 14\u201317, Macao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.5765\/jkacap.250041","article-title":"Trends in Multimodal Artificial Intelligence for Autism Research in Children and Adolescents: A Scientometric Study","volume":"36","author":"Yan","year":"2025","journal-title":"J. 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