{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T17:59:12Z","timestamp":1785347952485,"version":"3.55.0"},"reference-count":75,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: Artificial intelligence (AI) is increasingly being evaluated for ophthalmic diagnosis, screening, and triage, yet its role in paediatric eye care remains less established than in adult ophthalmology. This systematic review aimed to synthesise evidence on AI-enabled tools for paediatric ophthalmic diagnosis, screening, triage, surveillance, and referral, with an emphasis on diagnostic performance, safety, workflow integration, equity, and implementation readiness in primary, community, and primary care-relevant settings. Methods: A PRISMA-guided systematic review was conducted using MEDLINE, Embase, Web of Science, Scopus, and IEEE Xplore from inception to 30 March 2026. Eligible studies evaluated AI or machine-learning tools for children and adolescents aged 0\u201318 years in relation to paediatric eye conditions. Study selection and data extraction were undertaken independently by reviewers, with disagreements resolved by consensus or third-reviewer adjudication. Methodological and reporting quality was evaluated using an author-adapted six-domain rubric informed by APPRAISE-AI. Diagnostic-accuracy studies were assessed using an author-adapted QUADAS-2 framework incorporating QUADAS-AI-informed AI-specific considerations, the prediction-model study was assessed using PROBAST+AI, and the non-randomised treatment-effect study was assessed using ROBINS-I. The public dataset descriptor was evaluated separately using an author-developed dataset-quality, representativeness, and applicability framework. Because of clinical and methodological heterogeneity, findings were synthesised thematically. Results: Twelve empirical studies and one public dataset descriptor were included, covering retinopathy of prematurity, retinoblastoma, amblyopia risk, myopia, congenital cataract, and visual-acuity assessment. AI systems frequently demonstrated promising diagnostic or screening performance, including sensitivity-first detection of treatment-requiring retinopathy of prematurity, high discrimination for retinoblastoma activity, and strong myopia prediction using fundus images. Several studies supported feasibility in neonatal, school, and community workflows using smartphone-based imaging, task-shifted operators, tele-referral, and human-in-the-loop review. However, external and temporal validation, calibration, patient-level reporting, subgroup and fairness assessment, and economic evaluation were limited. Conclusions: AI-enabled tools show promise for supporting selected paediatric ophthalmic screening, triage, and surveillance pathways, particularly when combined with image-quality control, explicit escalation, and human oversight. However, confidence in the reported performance is limited by single-centre studies and enriched samples, small numbers of clinically important cases, heterogeneous analytical units, potentially optimistic aggregation procedures, limited external or temporal validation, incomplete calibration, and absent fairness analyses. Routine autonomous implementation remains premature.<\/jats:p>","DOI":"10.3390\/diagnostics16152389","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T17:01:46Z","timestamp":1785344506000},"page":"2389","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Performance and Implementation of AI-Enabled Paediatric Ophthalmic Screening, Triage, Diagnosis, and Surveillance in Primary, Community, and Referral-Linked Pathways: A Systematic Review"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8728-0687","authenticated-orcid":false,"given":"Joel","family":"Somerville","sequence":"first","affiliation":[{"name":"Centre for Rural Health Science, University of the Highlands and Islands, Inverness IV2 3JH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2937-4347","authenticated-orcid":false,"given":"Mohammad Hussein","family":"Mustafa","sequence":"additional","affiliation":[{"name":"Dr. Sulaiman Alhabib Medical Group, King Fahad Road, Olaya, Riyadh 11643, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8556-9639","authenticated-orcid":false,"given":"Mohamed Mahmoud","family":"Seweid","sequence":"additional","affiliation":[{"name":"Faculty of Nursing, Beni-Suef University, Beni-Suef, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3822-9236","authenticated-orcid":false,"given":"Rabie Adel","family":"El Arab","sequence":"additional","affiliation":[{"name":"Department of Nursing, Mohammed Al-Mana College for Medical Sciences, Dammam 34222, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.ophtha.2023.09.005","article-title":"Impact of Vision Impairment and Ocular Morbidity and Their Treatment on Quality of Life in Children: A Systematic Review","volume":"131","author":"Li","year":"2024","journal-title":"Ophthalmology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"100495","DOI":"10.1016\/j.optom.2023.100495","article-title":"A systematic review of the impact of childhood vision impairment on reading and literacy in education","volume":"17","author":"Loh","year":"2024","journal-title":"J. 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