{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T09:02:00Z","timestamp":1785488520373,"version":"3.56.0"},"reference-count":8,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing","doi-asserted-by":"publisher","award":["7264314"],"award-info":[{"award-number":["7264314"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Cronkhite\u2013Canada syndrome is a rare, non-hereditary polyposis syndrome characterized by non-specific gastrointestinal symptoms accompanied by alopecia, cutaneous hyperpigmentation, and nail dystrophy. Characteristic endoscopic findings are diffuse sessile polypoid lesions with edematous mucosa. We report a case of a 44-year-old woman in whom intestinal ultrasound and CT revealed diffuse mucosal thickening and an ileocecal intussusception\u2014findings that may not be pathognomonic but are highly unusual in adults. These imaging features served as critical red flags that directed the clinical suspicion toward Cronkhite\u2013Canada syndrome and prompted timely endoscopic confirmation.<\/jats:p>","DOI":"10.3390\/diagnostics16152415","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T08:20:18Z","timestamp":1785486018000},"page":"2415","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intussusception in Cronkhite\u2013Canada Syndrome"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5380-0499","authenticated-orcid":false,"given":"Li","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Ultrasound, Peking Union Medical College Hospital, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Peking Union Medical College Hospital, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9092-7592","authenticated-orcid":false,"given":"Xiaoyin","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Peking Union Medical College Hospital, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0618-2381","authenticated-orcid":false,"given":"Qingli","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Peking Union Medical College Hospital, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1097\/00005792-198209000-00002","article-title":"The Cronkhite-Canada Syndrome. An analysis of clinical and pathologic features and therapy in 55 patients","volume":"61","author":"Daniel","year":"1982","journal-title":"Medicine"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/S2468-1253(21)00172-2","article-title":"Polypoid lesions in the stomach and the colon: Cronkhite-Canada syndrome","volume":"6","author":"Kunishi","year":"2021","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1038\/ajg.2016.92","article-title":"Cronkhite Canada Syndrome: Significant Response to Infliximab and a Possible Clue to Pathogenesis","volume":"111","author":"Boland","year":"2016","journal-title":"Am. J. Gastroenterol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1055\/s-0034-1377539","article-title":"Successful treatment of Cronkhite-Canada syndrome using anti-tumor necrosis factor antibody therapy","volume":"46","author":"Watanabe","year":"2014","journal-title":"Endoscopy"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s00535-015-1107-7","article-title":"Endoscopic and clinical evaluation of treatment and prognosis of Cronkhite-Canada syndrome: A Japanese nationwide survey","volume":"51","author":"Watanabe","year":"2016","journal-title":"J. Gastroenterol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e118\u2013119","DOI":"10.1016\/j.cgh.2011.06.003","article-title":"Cronkhite-Canada syndrome associated with sigmoid colon cancer","volume":"9","author":"Maruno","year":"2011","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"200","DOI":"10.4240\/wjgs.v14.i2.200","article-title":"Surgery for Cronkhite-Canada syndrome complicated with intussusception: A case report and review of literature","volume":"14","author":"Dong","year":"2022","journal-title":"World J. Gastrointest. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.2169\/internalmedicine.49.2813","article-title":"Cecal intussusception in an adult with Cronkhite-Canada syndrome relieved by colonoscopy","volume":"49","author":"Ishikawa","year":"2010","journal-title":"Intern. Med."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/15\/2415\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T08:39:36Z","timestamp":1785487176000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/15\/2415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,31]]},"references-count":8,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["diagnostics16152415"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics16152415","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,31]]}}}