{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:41:49Z","timestamp":1792291309996,"version":"4.4.0"},"reference-count":36,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: Volumetric evaluation is critical in living donor liver transplantation. Liver volume, depending on body weight and height, and radiological estimates have made important contributions, but some inconsistencies remain. We aimed to assess the estimated and radiological liver volumes with respect to actual graft weight and potential factors contributing to inaccuracy. Method: A total of 623 donors were evaluated in this retrospective study. The estimated liver volumes were calculated with the Vauthey formula. The laboratory and liver biopsy results were obtained. Three-dimensional liver tomography was used to assess liver volume. Actual graft weight was measured on the back table after perfusion. Graft types were recorded. A discrepancy of more than 10% is accepted as discordant. The possible reasons were evaluated. Results: The mean estimated liver volume and radiological liver volume were 1216 cm3 and 1290 cm3, respectively. The mean radiological right lobe volume and the actual right lobe graft weight were 815 and 846, respectively. Liver density, liver steatosis percentage, blood cholesterol levels, blood triglyceride levels, and blood total bilirubin levels are factors contributing to the disparity between the estimated and radiological volume differences. Vitamin B12 and albumin levels were associated with the discrepancy between radiological liver volume and actual graft weight. Underestimation was significant in the left lateral lobe. Conclusions: Three-dimensional volumetry is useful for size matching. Discrepancies of more than 10% are attributable to liver steatosis or splitting lines.<\/jats:p>","DOI":"10.3390\/diagnostics16152442","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T06:17:40Z","timestamp":1785737860000},"page":"2442","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Factors Affecting Disparity Between Estimated Liver Volume and Actual Liver Volume in Living Donor Liver Transplantation"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2344-7783","authenticated-orcid":false,"given":"Tonguc Utku","family":"Y\u0131lmaz","sequence":"first","affiliation":[{"name":"Department of General Surgery, School of Medicine, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8726-5092","authenticated-orcid":false,"given":"Emre","family":"Tun\u00e7can","sequence":"additional","affiliation":[{"name":"School of Medicine, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8962-4909","authenticated-orcid":false,"given":"Abdurrahman Furkan","family":"Ceti\u015fli","sequence":"additional","affiliation":[{"name":"School of Medicine, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aylin Altan","family":"Ku\u015f","sequence":"additional","affiliation":[{"name":"Department of Radiology, Atakent Hospital, Acibadem Mehmet Ali Aydinlar University, Istanbul 34303, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fczide","family":"\u00d6zdil","sequence":"additional","affiliation":[{"name":"Department of Radiology, Atakent Hospital, Acibadem Mehmet Ali Aydinlar University, Istanbul 34303, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"\u00d6zer","sequence":"additional","affiliation":[{"name":"Organ Transplantation Unit, Atakent Hospital, Acibadem Acibadem Mehmet Ali Aydinlar University, Istanbul 34303, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0367-8373","authenticated-orcid":false,"given":"Murat","family":"Y\u0131ldar","sequence":"additional","affiliation":[{"name":"Organ Transplantation Unit, Atakent Hospital, Acibadem Acibadem Mehmet Ali Aydinlar University, Istanbul 34303, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamdi","family":"Karakayal\u0131","sequence":"additional","affiliation":[{"name":"Organ Transplantation Unit, Atakent Hospital, Acibadem Acibadem Mehmet Ali Aydinlar University, Istanbul 34303, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1097\/TP.0000000000004770","article-title":"Post Living Donor Liver Transplantation Small-for-size Syndrome: Definitions, Timelines, Biochemical, and Clinical Factors for Diagnosis: Guidelines from the ILTS-iLDLT-LTSI Consensus Conference","volume":"107","author":"Kow","year":"2023","journal-title":"Transplantation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1002\/lt.21562","article-title":"Donor safety and remnant liver volume in living donor liver transplantation","volume":"14","author":"Taner","year":"2008","journal-title":"Liver Transplant."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1053\/jlts.2002.31654","article-title":"Body surface area and body weight predict total liver volume in western adults","volume":"8","author":"Vauthey","year":"2002","journal-title":"Liver Transplant."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1002\/lt.20113","article-title":"Estimation of liver size for liver transplantation: The impact of age and gender","volume":"10","author":"Martignoni","year":"2004","journal-title":"Liver Transplant."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"4052","DOI":"10.1016\/j.transproceed.2009.08.079","article-title":"Estimation of Standard Liver Volume in Chinese Adult Living Donors","volume":"41","author":"Bo","year":"2009","journal-title":"Transpl. Proc."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"W568","DOI":"10.2214\/AJR.11.7468","article-title":"Automated liver volumetry in orthotopic liver transplantation using multiphase acquisitions on MDCT","volume":"198","author":"Luciani","year":"2012","journal-title":"Am. J. Roentgenol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"W706","DOI":"10.2214\/AJR.10.5958","article-title":"Quantitative radiology: Automated CT liver volumetry compared with interactive volumetry and manual volumetry","volume":"197","author":"Suzuki","year":"2011","journal-title":"Am. J. Roentgenol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3350\/cmh.2017.0023","article-title":"Resection plane-dependent error in computed tomography volumetry of the right hepatic lobe in living liver donors","volume":"24","author":"Kwon","year":"2018","journal-title":"Clin. Mol. Hepatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1002\/lt.21547","article-title":"Accuracy of an age-adjusted formula in assessing the graft volume in liver donor liver transplantation","volume":"14","author":"Kayashima","year":"2008","journal-title":"Liver Transplant."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"167","DOI":"10.21037\/hbsn.2017.08.02","article-title":"Accuracy of preoperative CT liver volumetry in living donor hepatectomy and its clinical implications","volume":"7","author":"Goja","year":"2018","journal-title":"Hepatobiliary Surg. Nutr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.transproceed.2019.12.042","article-title":"Comparison Between Pre-operative Radiologic Findings and the Actual Operative Findings of the Graft in Adult Living Donor Liver Transplantation","volume":"52","author":"Seleem","year":"2020","journal-title":"Transpl. Proc."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4274\/dir.2023.221903","article-title":"Manual and semi-automated computed tomography volumetry significantly overestimates the right liver lobe graft weight: A single-center study with adult living liver donors","volume":"30","author":"Odaman","year":"2024","journal-title":"Diagn. Interv. Radiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jceh.2019.03.006","article-title":"Three-Dimensional Volumetric Assessment of Graft Volume in Living Donor Liver Transplantation: Does It Minimise Errors of Estimation?","volume":"10","author":"Mohapatra","year":"2020","journal-title":"J. Clin. Exp. Hepatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1016\/j.transproceed.2019.01.152","article-title":"Liver Graft Volume Estimation by Manual Volumetry and Software-Aided Interactive Volumetry: Which is Better?","volume":"51","author":"Bozkurt","year":"2019","journal-title":"Transpl. Proc."},{"key":"ref_15","first-page":"2917","article-title":"Correlation between CT volumetry and actual graft weight in living donor liver transplants in South Africa","volume":"28","author":"Calver","year":"2024","journal-title":"SA J. Radiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1002\/lt.20537","article-title":"Validity of Preoperative volumetric analysis of congestion volume in living donor liver transplantation using three-dimensional computed tomography","volume":"11","author":"Yonemura","year":"2005","journal-title":"Liver Transplant."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1148\/radiol.2403042062","article-title":"Living donor right liver lobes: Preoperative CT volumetric measurement for calculation of intraoperative weight and volume","volume":"240","author":"Lemke","year":"2006","journal-title":"Radiology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1002\/hep.1840210515","article-title":"Calculation of child and adult standard liver volume for liver transplantation","volume":"21","author":"Urata","year":"1995","journal-title":"Hepatology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1002\/lt.500050516","article-title":"Standard liver volume in the Caucasian population","volume":"5","author":"Heinemann","year":"1999","journal-title":"Liver Transplant. Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"4968","DOI":"10.3748\/wjg.v23.i27.4968","article-title":"New formula for predicting standard liver volume in Chinese adults","volume":"23","author":"Feng","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1007\/s12072-011-9264-0","article-title":"Validation of graft and standard liver size predictions in right liver living donor liver transplantation","volume":"5","author":"Chan","year":"2011","journal-title":"Hepatol. Int."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Liang, C., Yu, Z., Bai, L., Hou, W., Tang, S., Zhang, W., Chen, X., Hu, Z., Duan, Z., and Zheng, S. (2022). Association of Serum Bilirubin With Metabolic Syndrome and Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis. Front. Endocrinol., 13.","DOI":"10.3389\/fendo.2022.869579"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3877","DOI":"10.1007\/s00261-021-03058-z","article-title":"Change in hepatic volume profile in potential live liver donors after lifestyle modification for reduction of hepatic steatosis","volume":"46","author":"Park","year":"2021","journal-title":"Abdom. Radiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1186\/2047-783X-15-8-345","article-title":"Liver volume measurement: Reason of the difference between in vivo CT-volumetry and intraoperative ex vivo determination and how to cope it","volume":"15","author":"Niehues","year":"2010","journal-title":"Eur. J. Med. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1007\/s00330-003-2161-8","article-title":"3D CT modeling of hepatic vessel architecture and volume calculation in living donated liver transplantation","volume":"14","author":"Frericks","year":"2004","journal-title":"Eur. Radiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1007\/s00534-011-0374-9","article-title":"Discrepancy between estimated and actual weight of partial liver graft from living donors","volume":"18","author":"Satou","year":"2011","journal-title":"J. Hepatobiliary Pancreat. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1097\/01.TP.0000053755.08825.12","article-title":"Accurate preoperative estimation of liver-graft volumetry using three-dimensional computed tomography","volume":"75","author":"Hiroshige","year":"2003","journal-title":"Transplantation"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1002\/lt.20188","article-title":"Estimation of standard liver volume for liver transplantation in the Korean population","volume":"10","author":"Yu","year":"2004","journal-title":"Liver Transplant."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Takahashi, H., Kawanaka, M., Fujii, H., Iwaki, M., Hayashi, H., Toyoda, H., Oeda, S., Hyogo, H., Morishita, A., and Munekage, K. (2023). Association of Serum Albumin Levels and Long-Term Prognosis in Patients with Biopsy-Confirmed Nonalcoholic Fatty Liver Disease. Nutrients, 15.","DOI":"10.3390\/nu15092014"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s10895-009-0522-7","article-title":"The interaction of serum albumin with cholesterol containing lipid vesicles","volume":"20","author":"Meierhofer","year":"2010","journal-title":"J. Fluoresc."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"7174","DOI":"10.1021\/bi952242v","article-title":"Serum albumin is a significant intermediate in cholesterol transfer between cells and lipoproteins","volume":"35","author":"Zhao","year":"1996","journal-title":"Biochemistry"},{"key":"ref_32","first-page":"31","article-title":"Falsely elevated serum vitamin B12 levels were associated with the severity and prognosis of chronic viral liver disease","volume":"60","author":"Sugihara","year":"2017","journal-title":"Yonago Acta Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.2310\/JIM.0b013e31822a29f5","article-title":"Association between serum Vitamin B12 levels and the degree of steatosis in patients with nonalcoholic fatty liver disease","volume":"59","author":"Koplay","year":"2011","journal-title":"J. Investig. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1590\/s0004-2803.202100000-42","article-title":"Vitamin b12 and homocysteine levels in patients with nafld: A systematic review and metanalysis","volume":"58","author":"Costa","year":"2021","journal-title":"Arq. Gastroenterol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Al-Musharaf, S., Aljuraiban, G.S., Hussain, S.D., Alnaami, A.M., Saravanan, P., and Al-Daghri, N. (2020). Low serum vitamin B12 levels are associated with adverse lipid profiles in apparently healthy young Saudi women. Nutrients, 12.","DOI":"10.3390\/nu12082395"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Zhu, J., Liao, X., Du, L., Lv, P., and Deng, J. (2024). Associations of serum folate and vitamin B12 levels with all-cause mortality among patients with metabolic dysfunction associated steatotic liver disease: A prospective cohort study. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1426103"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/15\/2442\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T06:36:46Z","timestamp":1785739006000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/15\/2442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,2]]},"references-count":36,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["diagnostics16152442"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics16152442","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,2]]}}}