{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T09:48:30Z","timestamp":1785923310119,"version":"3.56.0"},"reference-count":22,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: Inherited thrombophilia (IT) has been extensively investigated as a potential contributor to adverse pregnancy outcomes; however, reported prevalence varies widely across studies. This systematic review aimed to evaluate how cohort selection influences the reported prevalence of inherited thrombophilia in pregnancy and to explore the implications of this variability for clinical interpretation and screening practices. Methods: A systematic review was conducted following PRISMA 2020 guidelines. PubMed, Scopus, Web of Science, and Google Scholar were searched. A total of 5480 records were identified, and 7 observational studies (cohort and case\u2013control) met inclusion criteria. Data were synthesized qualitatively due to heterogeneity. Results: Prevalence ranged from 0% to 14%, depending on population characteristics. The largest cohort study reported an inherited thrombophilia prevalence of 8.1%, comparable to the general population. Higher rates were observed in referral-based and antiphospholipid Syndrome (APS)-associated cohorts, while case\u2013control studies showed no significant differences between affected individuals and controls. Ethnic variability was also observed. Conclusions: These findings should be interpreted as patterns observed across heterogeneous study designs rather than as definitive evidence of causality. Current evidence does not clearly support universal screening in pregnancy; however, the findings should be interpreted cautiously because several included studies were limited by small sample sizes and methodological heterogeneity.<\/jats:p>","DOI":"10.3390\/diagnostics16152466","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T09:16:22Z","timestamp":1785921382000},"page":"2466","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reported Prevalence of Inherited Thrombophilia in Pregnancy: Impact of Cohort Selection on Screening Implications\u2014A Systematic Review"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1992-1766","authenticated-orcid":false,"given":"Maria","family":"Fulina","sequence":"first","affiliation":[{"name":"County Clinical Emergency Hospital \u201cSf. Ap. Andrei\u201d, 900591 Constanta, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5969-6688","authenticated-orcid":false,"given":"Lucian","family":"\u0218erb\u0103nescu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Ovidius University of Constanta, Aleea Universit\u0103\u021bii no.1 , Campus\u2014Building B, 900470 Constanta, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgeta-Camelia","family":"Cozaru","sequence":"additional","affiliation":[{"name":"County Clinical Emergency Hospital \u201cSf. Ap. Andrei\u201d, 900591 Constanta, Romania"},{"name":"Center for Research and Development of the Morphological and Genetic Studies of Malignant Pathology (CEDMOG), \u201cOvidius\u201d University of Constanta, 900591 Constanta, Romania"},{"name":"Academy of Romanian Scientists, 3 Ilfov Street, 050094 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6591-0038","authenticated-orcid":false,"given":"Elena","family":"Dante\u0219","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Ovidius University of Constanta, Aleea Universit\u0103\u021bii no.1 , Campus\u2014Building B, 900470 Constanta, Romania"},{"name":"Doctoral School of Medicine, Faculty of Medicine, Ovidius University of Constanta, 1 University Alley, Campus\u2014Corp B, 900470 Constanta, Romania"},{"name":"Clinical Hospital of Pneumopthisiology Constanta, 40 Santinelei Street, 900002 Constanta, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4679-899X","authenticated-orcid":false,"given":"Elena","family":"Dumea","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Ovidius University of Constanta, Aleea Universit\u0103\u021bii no.1 , Campus\u2014Building B, 900470 Constanta, Romania"},{"name":"Clinical Hospital of Infectious Diseases, 900178 Constanta, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5847-3977","authenticated-orcid":false,"given":"Eugenia-Alina","family":"Radu","sequence":"additional","affiliation":[{"name":"County Clinical Emergency Hospital \u201cSf. Ap. Andrei\u201d, 900591 Constanta, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2386-543X","authenticated-orcid":false,"given":"Elena","family":"Mocanu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Ovidius University of Constanta, Aleea Universit\u0103\u021bii no.1 , Campus\u2014Building B, 900470 Constanta, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1055\/s-2005-872430","article-title":"MTHFR C677T polymorphism and factor V Leiden mutation are not associated with recurrent spontaneous abortion of unexplained etiology in Japanese women","volume":"31","author":"Kobashi","year":"2005","journal-title":"Semin. Thromb. 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