{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T12:29:47Z","timestamp":1786969787211,"version":"build-2736575974"},"reference-count":28,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"crossref","award":["SZSM202411024"],"award-info":[{"award-number":["SZSM202411024"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270930"],"award-info":[{"award-number":["82270930"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82571032"],"award-info":[{"award-number":["82571032"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"award":["82270930"],"award-info":[{"award-number":["82270930"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"award":["82571032"],"award-info":[{"award-number":["82571032"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Shenzhen High-level Hospital Construction Fund","award":["KYQD2026002"],"award-info":[{"award-number":["KYQD2026002"]}]},{"name":"Clinical Research Fund of the National Clinical Research Center for Geriatric Disorders","award":["2023LNJJ9"],"award-info":[{"award-number":["2023LNJJ9"]}]},{"award":["2023LNJJ9"],"award-info":[{"award-number":["2023LNJJ9"]}],"id":[{"id":"https:\/\/ror.org\/03ddkvp86","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: Obstructive sleep apnea (OSA) and primary aldosteronism (PA) are linked by bidirectional mechanisms. Although guidelines recommend PA screening in hypertensive patients with OSA, simple tools for clinical prioritization remain limited. We aimed to characterize clinical, polysomnographic, and biochemical features associated with coexisting PA in patients with OSA. Methods: We conducted a cross-sectional study in 107 adults with OSA and definitive PA classification, including 30 patients in the OSA+PA group and 77 in the OSA-only group. Clinical, polysomnographic, and fasting biochemical variables were collected using standardized procedures. Multivariable logistic regression was used to examine factors associated with coexisting PA. Results: Compared with the OSA-only group, the OSA+PA group had a larger neck circumference (42.0 \u00b1 4.6 vs. 39.8 \u00b1 3.7 cm, p = 0.010), a higher snoring index (369.9 \u00b1 320.3 vs. 252.0 \u00b1 264.9, p = 0.040), and higher aldosterone levels (25.8 \u00b1 18.8 vs. 10.7 \u00b1 7.3 ng\/dL, p = 0.001), while glycated hemoglobin was lower (6.4 \u00b1 1.6 vs. 7.5 \u00b1 2.1, p = 0.005) and serum potassium was significantly reduced (3.5 \u00b1 0.4 vs. 4.0 \u00b1 0.4 mmol\/L, p = 0.001). In multivariable analysis, aldosterone (OR = 1.138, p = 0.001) and serum potassium (OR = 0.017, p = 0.001) were associated with coexisting PA. Conclusions: Higher aldosterone and lower serum potassium were readily available biochemical features associated with coexisting PA among clinically selected patients with OSA.<\/jats:p>","DOI":"10.3390\/diagnostics16162565","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T10:39:01Z","timestamp":1786703941000},"page":"2565","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and Biochemical Features Associated with Coexisting Primary Aldosteronism in Patients with Obstructive Sleep Apnea: A Cross-Sectional Study"],"prefix":"10.3390","volume":"16","author":[{"given":"Mingliu","family":"Li","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Xiangya Hospital, Central South University, Changsha 410008, China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China"},{"name":"Department of Geriatric Endocrinology and Metabolism, Guangxi Academy of Medical Sciences, The People\u2019s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuyong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Xiangya Hospital, Central South University, Changsha 410008, China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China"},{"name":"Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Teng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Xiangya Hospital, Central South University, Changsha 410008, China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biling","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Xiangya Hospital, Central South University, Changsha 410008, China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Xiangya Hospital, Central South University, Changsha 410008, China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Xiangya Hospital, Central South University, Changsha 410008, China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Xiangya Hospital, Central South University, Changsha 410008, China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Xiangya Hospital, Central South University, Changsha 410008, China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Su","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China"},{"name":"Department of Respiratory, Xiangya Hospital, Central South University, Changsha 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiejian","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Xiangya Hospital, Central South University, Changsha 410008, China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2111-3074","authenticated-orcid":false,"given":"Min","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Xiangya Hospital, Central South University, Changsha 410008, China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China"},{"name":"Department of Endocrinology, Peking University Shenzhen Hospital, Shenzhen 518036, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Platon, A.L., Stelea, C.G., Boi\u0219teanu, O., Patrascanu, E., Zetu, I.N., Ro\u0219u, S.N., Trifan, V., and Palade, D.O. 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