{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T09:24:18Z","timestamp":1787217858857,"version":"build-2736575974"},"reference-count":42,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan","award":["TCRD112-79"],"award-info":[{"award-number":["TCRD112-79"]}]},{"name":"Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan","award":["TCMF-A 107-01-05"],"award-info":[{"award-number":["TCMF-A 107-01-05"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: Selenoprotein P (SePP) has been linked to cardiovascular risk, but its relationship with aortic stiffness in patients on maintenance hemodialysis (MHD) is unclear. This study examined that association. Methods: In this cross-sectional study of 138 patients on MHD, serum SePP levels were measured with enzyme-linked immunosorbent assay, and carotid-femoral pulse wave velocity (cfPWV) was measured using the SphygmoCor system. Aortic stiffness was defined as a cfPWV of &gt;10 m\/s. Associations of SePP with cfPWV and aortic stiffness were assessed by correlation, linear regression, and penalized logistic regression. Results: Fifty-six patients (40.6%) had aortic stiffness and had lower serum SePP levels than those without aortic stiffness (p = 0.001). Patients with aortic stiffness were older (p = 0.037) and had higher systolic blood pressure (p = 0.005), higher glucose (p = 0.021) and C-reactive protein (p = 0.021) levels, and a higher prevalence of diabetes mellitus (p = 0.034) and hypertension (p = 0.006). Log-transformed SePP was independently and inversely associated with log-transformed cfPWV in both the forward stepwise and forced-entry models (p &lt; 0.001 for both). By Spearman\u2019s analysis, SePP was negatively correlated with cfPWV (p &lt; 0.001). After adjustment for significant covariates, higher SePP levels remained independently associated with lower odds of aortic stiffness in multivariable and penalized logistic regression models. Conclusions: Lower serum SePP levels were independently associated with higher cfPWV and greater odds of aortic stiffness in patients receiving MHD.<\/jats:p>","DOI":"10.3390\/diagnostics16162650","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T08:10:20Z","timestamp":1787213420000},"page":"2650","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lower Serum Selenoprotein P Levels Are Associated with Aortic Stiffness in Patients Receiving Maintenance Hemodialysis"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9239-6932","authenticated-orcid":false,"given":"Chiu-Huang","family":"Kuo","sequence":"first","affiliation":[{"name":"Division of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97004, Taiwan"},{"name":"School of Post-Baccalaureate Chinese Medicine, Tzu Chi University, Hualien 97004, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9549-9232","authenticated-orcid":false,"given":"Chih-Hsien","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97004, Taiwan"},{"name":"School of Medicine, Tzu Chi University, Hualien 97004, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9094-0589","authenticated-orcid":false,"given":"Yu-Li","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97004, Taiwan"},{"name":"School of Medicine, Tzu Chi University, Hualien 97004, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6687-1058","authenticated-orcid":false,"given":"Yu-Hsien","family":"Lai","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97004, Taiwan"},{"name":"Department of Pharmacology, School of Medicine, Tzu Chi University, Hualien 97004, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5941-4414","authenticated-orcid":false,"given":"Chi-Chong","family":"Tang","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97004, Taiwan"},{"name":"School of Medicine, Tzu Chi University, Hualien 97004, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9364-4558","authenticated-orcid":false,"given":"Bang-Gee","family":"Hsu","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97004, Taiwan"},{"name":"School of Medicine, Tzu Chi University, Hualien 97004, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"685517","DOI":"10.3389\/fnut.2021.685517","article-title":"Selenium transport mechanism via selenoprotein P-its physiological role and related diseases","volume":"8","author":"Saito","year":"2021","journal-title":"Front. 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