{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T04:22:26Z","timestamp":1787458946540,"version":"build-2736575974"},"reference-count":35,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["R03 TR004005-01A1"],"award-info":[{"award-number":["R03 TR004005-01A1"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"award":["R03 TR004005-01A1"],"award-info":[{"award-number":["R03 TR004005-01A1"]}],"id":[{"id":"https:\/\/ror.org\/04pw6fb54","id-type":"ROR","asserted-by":"publisher"}]},{"name":"NSF","award":["DMS-2436232"],"award-info":[{"award-number":["DMS-2436232"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: Chronic rhinosinusitis (CRS) is commonly accompanied by sleep disturbance and cognitive complaints, but the relationships among CRS, cognition, subjective sleep, and circulating inflammatory cytokines remain incompletely understood. Methods: In this case\u2013control study, 80 adults with CRS and 98 controls completed validated sleep and sinonasal questionnaires and a 12-test cognitive battery assessing six domains. Plasma cytokines were measured in 101 participants with available biospecimens. Multivariable linear regression and exploratory correlation analyses were performed with false discovery rate correction. Results: Adjusted cognitive domain scores did not differ between CRS and controls. In age-by-group interaction models, CRS showed a nominally steeper age-associated decrease in episodic memory (\u03b2 = \u22120.12, 95% CI \u22120.21 to \u22120.03; p = 0.009; q = 0.053), with weaker nominal patterns for working memory (\u03b2 = \u22120.10, 95% CI \u22120.20 to \u22120.003; p = 0.044; q = 0.096) and visuospatial ability (\u03b2 = \u22120.08, 95% CI \u22120.15 to \u22120.001; p = 0.048; q = 0.096). Plasma IL-6 was nominally higher in CRS after adjustment (\u03b2 = 0.36, 95% CI 0.04 to 0.67; p = 0.026; q = 0.18) but did not remain significant after cytokine-level correction. Within CRS, exploratory analyses showed nominal inverse correlations between IL-6 and visuospatial ability (\u03c1 = \u22120.36; p = 0.008; q = 0.236), as well as a nominal positive correlation between IL-13 and semantic memory (\u03c1 = 0.33; p = 0.020; q = 0.236); however, none survived correction for multiple comparisons. Conclusions: Adults with CRS reported greater sleep-related burden and showed a nominally steeper age-related decrease in episodic memory. IL-6 and IL-13 showed nominal cognitive associations that did not survive correction, supporting the need for larger longitudinal studies to clarify clinical relevance.<\/jats:p>","DOI":"10.3390\/diagnostics16162671","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T08:14:01Z","timestamp":1787300041000},"page":"2671","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of Sleep, Cognitive Performance, and Circulating Cytokines in Adults with Chronic Rhinosinusitis"],"prefix":"10.3390","volume":"16","author":[{"given":"Rachel","family":"Nolte","sequence":"first","affiliation":[{"name":"Division of Allergy and Immunology, Department of Internal Medicine, UT Health Houston, 6410 Fannin St, Houston, TX 77030, USA"},{"name":"Department of Internal Medicine, Dell Medical School, University of Texas at Austin, Austin, TX 78712, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donyea L.","family":"Moore","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Department of Internal Medicine, UT Health Houston, 6410 Fannin St, Houston, TX 77030, USA"},{"name":"Division of Allergy and Immunology, Department of Internal Medicine, Rush University Medical Center, 1725 W Harrison St, Chicago, IL 60612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yitong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Mathematical Sciences, Smith College, 10 Elm St, Northampton, MA 01063, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3753-6200","authenticated-orcid":false,"given":"Shreya","family":"Maharana","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Department of Internal Medicine, Rush University Medical Center, 1725 W Harrison St, Chicago, IL 60612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bichun","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences, Rush University Medical Center, 600 S Paulina St, Chicago, IL 60612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saloni","family":"Sharma","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Department of Internal Medicine, UT Health Houston, 6410 Fannin St, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baharan","family":"Fekry","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Department of Internal Medicine, UT Health Houston, 6410 Fannin St, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9742-4225","authenticated-orcid":false,"given":"Evan A.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, Rush University Medical Center, 1611 W Harrison St, Chicago, IL 60612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pete","family":"Batra","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, Rush University Medical Center, 1611 W Harrison St, Chicago, IL 60612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4004-203X","authenticated-orcid":false,"given":"Mahboobeh","family":"Mahdavinia","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Department of Internal Medicine, UT Health Houston, 6410 Fannin St, Houston, TX 77030, USA"},{"name":"Division of Allergy and Immunology, Department of Internal Medicine, Rush University Medical Center, 1725 W Harrison St, Chicago, IL 60612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"ref_1","first-page":"S1","article-title":"Clinical practice guideline (update): Adult sinusitis","volume":"152","author":"Rosenfeld","year":"2015","journal-title":"Otolaryngol. Head. Neck Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"134","DOI":"10.2500\/ajra.2016.30.4297","article-title":"Chronic rhinosinusitis: Epidemiology and burden of disease","volume":"30","author":"DeConde","year":"2016","journal-title":"Am. J. Rhinol. Allergy"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s11882-010-0175-2","article-title":"Quality of life in patients with chronic rhinosinusitis","volume":"11","author":"Rudmik","year":"2011","journal-title":"Curr. Allergy Asthma Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nrendo.2009.23","article-title":"Effects of poor and short sleep on glucose metabolism and obesity risk","volume":"5","author":"Spiegel","year":"2009","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1002\/alr.21581","article-title":"Cognitive function in chronic rhinosinusitis: A controlled clinical study","volume":"5","author":"Soler","year":"2015","journal-title":"Int. Forum Allergy Rhinol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1046\/j.1532-5415.2002.50619.x","article-title":"Cytokines and cognition--the case for a head-to-toe inflammatory paradigm","volume":"50","author":"Wilson","year":"2002","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.ncl.2006.03.010","article-title":"Age and neuroinflammation: A lifetime of psychoneuroimmune consequences","volume":"24","author":"Godbout","year":"2006","journal-title":"Neurol. Clin."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e2294","DOI":"10.1212\/WNL.0000000000201116","article-title":"Association of Midlife Inflammatory Markers With Cognitive Performance at 10-Year Follow-up","volume":"99","author":"Kipinoinen","year":"2022","journal-title":"Neurology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1210\/jc.2003-031562","article-title":"Adverse effects of modest sleep restriction on sleepiness, performance, and inflammatory cytokines","volume":"89","author":"Vgontzas","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Thompson, K.I., Chau, M., Lorenzetti, M.S., Hill, L.D., Fins, A.I., and Tartar, J.L. (2022). Acute sleep deprivation disrupts emotion, cognition, inflammation, and cortisol in young healthy adults. Front. Behav. Neurosci., 16.","DOI":"10.3389\/fnbeh.2022.945661"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1080\/23328940.2022.2109932","article-title":"Sleep disruption induces activation of inflammation and heightens risk for infectious disease: Role of impairments in thermoregulation and elevated ambient temperature","volume":"10","author":"Irwin","year":"2023","journal-title":"Temperature"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0165-1781(89)90047-4","article-title":"The Pittsburgh Sleep Quality Index: A new instrument for psychiatric practice and research","volume":"28","author":"Buysse","year":"1989","journal-title":"Psychiatry Res."},{"key":"ref_13","first-page":"835","article-title":"An instrument to measure functional status outcomes for disorders of excessive sleepiness","volume":"20","author":"Weaver","year":"1997","journal-title":"Sleep"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1093\/sleep\/14.6.540","article-title":"A new method for measuring daytime sleepiness: The Epworth sleepiness scale","volume":"14","author":"Johns","year":"1991","journal-title":"Sleep"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.smrv.2007.07.005","article-title":"Epidemiology of the human circadian clock","volume":"11","author":"Roenneberg","year":"2007","journal-title":"Sleep Med. Rev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1749-4486.2009.01995.x","article-title":"Psychometric validity of the 22-item Sinonasal Outcome Test","volume":"34","author":"Hopkins","year":"2009","journal-title":"Clin. Otolaryngol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/alr.21057","article-title":"Comparison of disease-specific quality-of-life instruments in the assessment of chronic rhinosinusitis","volume":"2","author":"Litvack","year":"2012","journal-title":"Int. Forum Allergy Rhinol."},{"key":"ref_18","unstructured":"Lezak, M.D. (2004). Neuropsychological Assessment, Oxford University Press."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/npp.2009.126","article-title":"The episodic memory system: Neurocircuitry and disorders","volume":"35","author":"Dickerson","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Wechsler, D. (1997). Wechsler Adult Intelligence Scale, Psychological Corporation.","DOI":"10.1037\/t49755-000"},{"key":"ref_21","unstructured":"Ekstrom, R.B., and Harman, H.H. (1976). Manual for Kit of Factor-Referenced Cognitive Tests, 1976, Educational Testing Service."},{"key":"ref_22","unstructured":"Raven, J.C. (1960). Guide to the Standard Progressive Matrices, Sets A, B, C, D and E, K. Lewis & Co., Ltd."},{"key":"ref_23","unstructured":"Goodglass, H., Kaplan, E., and Weintraub, S. (1983). Boston Naming Test, Lea & Febiger."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1017\/S1355617704104141","article-title":"Verbal fluency deficits in Parkinson\u2019s disease: A meta-analysis","volume":"10","author":"Henry","year":"2004","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.cortex.2014.02.006","article-title":"Semantic fluency: Cognitive basis and diagnostic performance in focal dementias and Alzheimer\u2019s disease","volume":"54","author":"Reverberi","year":"2014","journal-title":"cortex"},{"key":"ref_26","unstructured":"Golden, C., Freshwater, S.M., and Golden, Z. (1978). Stroop Color and Word Test: A Manual for Clinical and Experimental Uses, Stoelting Company."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.bbi.2024.06.014","article-title":"Plasma IL-6 levels and their association with brain health and dementia risk: A population-based cohort study","volume":"120","author":"Zhao","year":"2024","journal-title":"Brain Behav. Immun."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Moore, D., Nolte, R., Huang, Y., Maharana, S., Nataraj, P., Ouyang, B., and Mahdavinia, M. (2025). Tailoring Evaluations of Chronic Rhinosinusitis: Understanding Sleep and Its Effect on Memory Through Actigraphy. J. Pers. Med., 15.","DOI":"10.3390\/jpm15060249"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"102982","DOI":"10.1016\/j.redox.2023.102982","article-title":"IL-10 protects against OPC ferroptosis by regulating lipid reactive oxygen species levels post stroke","volume":"69","author":"Wu","year":"2024","journal-title":"Redox Biol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S1474-4422(18)30461-7","article-title":"Association between circadian rhythms and neurodegenerative diseases","volume":"18","author":"Leng","year":"2019","journal-title":"Lancet Neurol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/B978-0-444-53817-8.00001-3","article-title":"Cognition in circadian rhythm sleep disorders","volume":"190","author":"Reid","year":"2011","journal-title":"Prog. Brain Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1146\/annurev-psych-022824-043825","article-title":"The Circadian Brain and Cognition","volume":"76","author":"Cajochen","year":"2025","journal-title":"Annu Rev. Psychol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"317","DOI":"10.2147\/NSS.S220436","article-title":"The Relationship Between Global Sleep Score And Inflammatory Markers In Obese Adults From The United States","volume":"11","author":"Huang","year":"2019","journal-title":"Nat. Sci. Sleep"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1055\/s-0038-1648248","article-title":"The Role of Modified Expansion Sphincter Pharyngoplasty in Multilevel Obstructive Sleep Apnea Syndrome Surgery","volume":"22","author":"Lorusso","year":"2018","journal-title":"Int. Arch. Otorhinolaryngol."},{"key":"ref_35","first-page":"281","article-title":"Obstructive sleep apnoea syndrome (OSAS): Effects on the vestibular system","volume":"30","author":"Gallina","year":"2010","journal-title":"Acta Otorhinolaryngol. Ital."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/16\/2671\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T04:18:21Z","timestamp":1787458701000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/16\/2671"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,21]]},"references-count":35,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["diagnostics16162671"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics16162671","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,21]]}}}