{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T10:34:44Z","timestamp":1787567684443,"version":"build-2736575974"},"reference-count":30,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background and Clinical Significance: Primary pancreatic extramedullary plasmacytomas (EMP) are extremely uncommon, representing less than 0.1% of all pancreatic masses and being far more uncommon than secondary involvement by an underlying multiple myeloma. Case presentation: A 69-year-old male was found with a solitary pancreatic mass. Endoscopic ultrasound (EUS)-guided fine-needle biopsy (FNB) revealed a monoclonal plasmacytic proliferation with molecularly confirmed KRAS (A146V) and BRAF (G469V) mutations. Multidisciplinary assessment ruled out a secondary localization, thus leading to the ultimate diagnosis of primary pancreatic EMP. Conclusions: Reaching a definitive diagnosis of primary pancreatic EMP requires a negative bone marrow biopsy and histological confirmation of the plasma cell nature of the pancreatic process. As for the latter, EUS-FNB may be a pivotal technique to avoid upfront surgical procedures.<\/jats:p>","DOI":"10.3390\/diagnostics16172680","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T09:20:02Z","timestamp":1787563202000},"page":"2680","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Solitary Pancreatic Extramedullary Plasmacytoma Diagnosed Through Endoscopic Ultrasound-Guided Fine-Needle Biopsy\u2014The Role of Endoscopic Diagnosis and Multidisciplinary Approach: A Case Report and Literature Review"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7881-8767","authenticated-orcid":false,"given":"Stefano","family":"Marletta","sequence":"first","affiliation":[{"name":"Division of Pathology, Humanitas Istituto Clinico Catanese, 95045 Catania, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, 20072 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Cavallo","sequence":"additional","affiliation":[{"name":"Division of Pathology, Humanitas Istituto Clinico Catanese, 95045 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8940-0929","authenticated-orcid":false,"given":"Michele","family":"Dello Spedale Venti","sequence":"additional","affiliation":[{"name":"Division of Pathology, Humanitas Istituto Clinico Catanese, 95045 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Bonanno","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Unit, Humanitas Istituto Clinico Catanese, 95045 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Romeo","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Unit, Humanitas Istituto Clinico Catanese, 95045 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"La Fauci","sequence":"additional","affiliation":[{"name":"Medical Oncology, Humanitas Istituto Clinico Catanese, 95045 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4938-4071","authenticated-orcid":false,"given":"Enzo","family":"Gallo","sequence":"additional","affiliation":[{"name":"UOC Pathology, IRCCS National Cancer Institute \u201cRegina Elena\u201d, 00128 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2856-4556","authenticated-orcid":false,"given":"Antonio","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Division of Pathology, Humanitas Istituto Clinico Catanese, 95045 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele Stefano Giovanni","family":"d\u2019Amore","sequence":"additional","affiliation":[{"name":"Division of Pathology, Humanitas Istituto Clinico Catanese, 95045 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariangela","family":"Novello","sequence":"additional","affiliation":[{"name":"UOC Pathology, IRCCS National Cancer Institute \u201cRegina Elena\u201d, 00128 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,22]]},"reference":[{"key":"ref_1","unstructured":"International Agency for Research on Cancer (2024). 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