{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T10:34:48Z","timestamp":1787567688971,"version":"build-2736575974"},"reference-count":12,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Chonnam National University Hospital Biomedical Research Institute","award":["BCRI26030"],"award-info":[{"award-number":["BCRI26030"]}]},{"award":["BCRI26030"],"award-info":[{"award-number":["BCRI26030"]}],"id":[{"id":"https:\/\/ror.org\/00f200z37","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: Accurate preoperative assessment of bone invasion is essential for surgical planning in gingival squamous cell carcinoma (SCC). This study evaluated the diagnostic value of conventional 18F-FDG PET\/CT-derived imaging parameters and PET-based radiomic features for predicting histopathologic bone invasion. Methods: This retrospective study included 68 patients with gingival SCC who underwent preoperative 18F-FDG PET\/CT followed by primary surgical treatment. Bone invasion was confirmed histopathologically. Conventional PET parameters (MTD, SUVmax, SUVmean, MTV, and TLG) and PET-based radiomic features were extracted from the primary tumor. Group comparisons, receiver operating characteristic (ROC) analysis, and univariate logistic regression were performed. Results: Patients with bone invasion showed significantly higher MTD, SUVmax, MTV, and TLG than those without bone invasion (all p &lt; 0.05), whereas SUVmean was not significantly different. Entropy, correlation, and zone entropy were significantly higher in the bone invasion-positive group. MTV showed the numerically highest AUC among conventional PET parameters (AUC = 0.748), whereas correlation (AUC = 0.725) and zone entropy (AUC = 0.714) showed the highest performance among radiomic features. Univariate logistic regression showed significant associations of MTD, MTV, TLG, entropy, correlation, and zone entropy with bone invasion. Conclusions: Conventional PET parameters and PET-based radiomic features were significantly associated with histopathologic bone invasion in gingival SCC. Radiomic features reflecting intratumoral heterogeneity may complement conventional metabolic parameters and improve preoperative assessment of bone invasion.<\/jats:p>","DOI":"10.3390\/diagnostics16172685","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T09:20:02Z","timestamp":1787563202000},"page":"2685","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Bone Invasion in Gingival Squamous Cell Carcinoma Using PET\/CT Radiomics"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4721-8595","authenticated-orcid":false,"given":"Junwoo","family":"Kwark","sequence":"first","affiliation":[{"name":"Department of Oral & Maxillofacial Surgery, Chonnam National University Hospital, Gwangju 61469, Republic of Korea"},{"name":"Department of Oral & Maxillofacial Surgery, School of Dentistry, Dental Science Research Institute, Chonnam National University, Gwangju 61186, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seunggon","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Oral & Maxillofacial Surgery, Chonnam National University Hospital, Gwangju 61469, Republic of Korea"},{"name":"Department of Oral & Maxillofacial Surgery, School of Dentistry, Dental Science Research Institute, Chonnam National University, Gwangju 61186, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Suk","family":"Kook","sequence":"additional","affiliation":[{"name":"Department of Oral & Maxillofacial Surgery, Chonnam National University Hospital, Gwangju 61469, Republic of Korea"},{"name":"Department of Oral & Maxillofacial Surgery, School of Dentistry, Dental Science Research Institute, Chonnam National University, Gwangju 61186, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Ju","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Oral & Maxillofacial Surgery, Chonnam National University Hospital, Gwangju 61469, Republic of Korea"},{"name":"Department of Oral & Maxillofacial Surgery, School of Dentistry, Dental Science Research Institute, Chonnam National University, Gwangju 61186, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junho","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Oral & Maxillofacial Surgery, Chonnam National University Hospital, Gwangju 61469, Republic of Korea"},{"name":"Department of Oral & Maxillofacial Surgery, School of Dentistry, Dental Science Research Institute, Chonnam National University, Gwangju 61186, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2940-5875","authenticated-orcid":false,"given":"Jaeyoung","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Oral & Maxillofacial Surgery, Chonnam National University Hospital, Gwangju 61469, Republic of Korea"},{"name":"Department of Oral & Maxillofacial Surgery, School of Dentistry, Dental Science Research Institute, Chonnam National University, Gwangju 61186, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.jcms.2016.02.003","article-title":"Diagnosing oral squamous cell carcinoma: How much imaging do we really need? 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Imaging"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/17\/2685\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T09:34:25Z","timestamp":1787564065000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/17\/2685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,22]]},"references-count":12,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["diagnostics16172685"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics16172685","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,22]]}}}