{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:16:37Z","timestamp":1790036197105,"version":"4.0.1"},"reference-count":20,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: Flow diverter stents are widely used for the treatment of complex, unruptured intracranial aneurysms. Nitinol-based devices offer improved flexibility and vessel conformability; however, real-world clinical outcome data remain limited. This study aimed to evaluate the safety and clinical outcomes of nitinol-based flow diverter stents in a single-center cohort. We hypothesized that these devices would demonstrate high technical success rates, low rates of device-related complications, and favorable functional outcomes at 6 months. Methods: We retrospectively analyzed 109 patients with unruptured saccular intracranial aneurysms treated with nitinol-based flow diverter stents between 2020 and 2025. Patients with ruptured aneurysms, non-nitinol devices, or incomplete 6-month follow-up data were excluded. Technical success, device-related complications, and clinical outcomes were assessed using standardized imaging follow-up at 1 month (CT angiography) and 6 months (digital subtraction angiography). Results: Technical success was achieved in 109\/109 cases (100%). The internal carotid artery cavernous segment was the most common aneurysm location. Intra- and peri-procedural device-related complications occurred in 12\/109 (11%) patients, all of which were successfully managed without permanent neurological deficit. During the 6-month follow-up, post-procedural device-related complications occurred in 5\/109 patients (4.6%), all due to delayed stent thrombosis requiring mechanical thrombectomy. One patient died due to persistent stent occlusion, and one patient developed unilateral lower-extremity plegia. Three patients experienced transient, non-device-related hypoesthesia that resolved during follow-up. At 6 months, most patients had favorable functional outcomes, with modified Rankin Scale scores of 0\u20131. Complete aneurysm occlusion was achieved in 83 of 108 patients (76.9%) at the 6-month angiographic follow-up. Conclusions: Flow diverter stents demonstrated high technical success and favorable clinical outcomes. Fishmouth deformity emerged as a potentially important technical factor associated with thrombotic complications and warrants careful recognition during deployment and follow-up.<\/jats:p>","DOI":"10.3390\/diagnostics16172777","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T04:24:03Z","timestamp":1788150243000},"page":"2777","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Outcomes and Device-Related Complications Following Flow Diverter Stent Treatment of Unruptured Intracranial Aneurysms: A Single-Center Retrospective Study"],"prefix":"10.3390","volume":"16","author":[{"given":"Necat","family":"Islamoglu","sequence":"first","affiliation":[{"name":"Konya City Hospital, 42020 Konya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Can","family":"Yalcin","sequence":"additional","affiliation":[{"name":"Konya City Hospital, 42020 Konya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilker","family":"Coven","sequence":"additional","affiliation":[{"name":"Konya City Hospital, 42020 Konya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1161\/STROKEAHA.112.678151","article-title":"Endovascular treatment of intracranial aneurysms with flow diverters: A meta-analysis","volume":"44","author":"Brinjikji","year":"2013","journal-title":"Stroke"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1148\/radiol.13120099","article-title":"Pipeline for uncoilable or failed aneurysms: Results from a multicenter clinical trial","volume":"267","author":"Becske","year":"2013","journal-title":"Radiology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.3174\/ajnr.A2023","article-title":"Treatment of intracranial aneurysms by functional reconstruction of the parent artery: The Budapest experience with the pipeline embolization device","volume":"31","author":"Szikora","year":"2010","journal-title":"AJNR Am. 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Neuroradiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1227\/01.neu.0000430297.17961.f1","article-title":"Flow-diverter devices for intracranial aneurysms: Systematic review and meta-analysis","volume":"73","author":"Arrese","year":"2013","journal-title":"Neurosurgery"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1136\/neurintsurg-2020-015877","article-title":"Review of current intracranial aneurysm flow diversion technology","volume":"13","author":"Dandapat","year":"2021","journal-title":"J. Neurointerv. Surg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.3174\/ajnr.A3246","article-title":"Treatment of intracranial aneurysms using the pipeline flow-diverter embolization device: A single-center experience with long-term follow-up results","volume":"33","author":"Saatci","year":"2012","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1177\/15910199221091645","article-title":"Patient outcomes after treatment of brain aneurysm in small diameter vessels with the silk vista baby flow diverter: A systematic review","volume":"30","author":"Hanel","year":"2024","journal-title":"Interv. Neuroradiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1136\/jnis-2022-019240","article-title":"Long-term outcomes of flow diversion for unruptured intracranial aneurysms: A systematic review and meta-analysis","volume":"15","author":"Shehata","year":"2023","journal-title":"J. Neurointerv. Surg."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/17\/2777\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T04:53:23Z","timestamp":1788152003000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/17\/2777"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,29]]},"references-count":20,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["diagnostics16172777"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics16172777","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,29]]}}}